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NCBI

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<~~font color="#800080" size="4"><strong~~p>Established in 1988 as a US national resource for molecular biology information, NCBI~~~~creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information - all for the better understanding of molecular processes affecting human health and disease

The National Center for Biotechnology Information~~. NCBI was establisehed in 1988.~~ (<~~br /~~strong>NCBI ~~ ~~) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988 through legislation sponsored by Senator Claude Pepper. The NCBI houses genome sequencing data in GenBank and an index of biomedical research articles in PubMed Central and PubMed, as well as other information relevant to biotechnology. All these databases are available online through the Entrez search engine.<~~font color="#99cc00" size="3"~~/p><~~strong~~p># The NCBI ~~Database~~is directed by David Lipman, one of the original authors of the BLAST sequence alignment program and a widely respected figure in Bioinformatics. He also leads an intramural research program, including groups led by Stephen Altschul (another BLAST co-author), David Landsman, and Eugene Koonin (a prolific author on comparative genomics). <~~/strong~~p> </~~font~~p><~~br /~~p><~~table style~~span class="~~BACKGROUND: #999999; WIDTH: 427.5pt; mso~~mw-~~cellspacing: .7pt; mso-padding-alt: 1.5pt 1.5pt 1.5pt 1.5pt~~headline" ~~cellspacing~~> GenBank<~~tbody~~/p> <~~tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes"~~p>The NCBI has had responsibility for making available the GenBank DNA sequence database since 1992. GenBank coordinates with individual laboratories and other sequence databases such as those of the European Molecular Biology Laboratory (EMBL) and the DNA Database of Japan (DDBJ). <~~td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1~~p>Since 1992, NCBI has grown to provide other databases in addition to GenBank.~~5pt; BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 1.5pt; BACKGROUND: #faf7f1; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1~~NCBI provides Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D protein structures), the Unique Human Gene Sequence Collection, a Gene Map of the Human genome, a Taxonomy Browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project.~~5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 426~~The NCBI assigns a unique identifier (Taxonomy ID number) to each species of organism.~~1pt; PADDING-TOP: 1.5pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-right-alt: solid windowtext .5pt" width="568" colspan="2"~~ The NCBI has software tools that are available by WWW browsing or by FTP. For example, BLAST is a sequence similarity searching program. BLAST can do sequence comparisons against the GenBank DNA database in less than 15 seconds.  ~~LINE-HEIGHT: 13pt; TEXT-AUTOSPACE: ideograph-numeric; TEXT-ALIGN: center; mso-pagination: widow-orphan" align="center"~~<~~strong~~p>NCBI</font~~-family: 굴림; mso-~~> <font~~-kerning: 0pt~~size="5">~~Database~~Bookshelf</~~strong~~p><~~span lang="EN-US" style="FONT-SIZE: 9pt; COLOR: #504f47; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-font-kerning: 0pt">~~p>The <~~/span~~strong>NCBI Bookshelf</pstrong> ~~</td>~~ ~~</tr>~~ ~~<tr style="mso~~is a collection of freely available, on-~~yfti-irow: 1">~~ ~~<td style="PADDING-RIGHT: 1~~line versions of selected biomedical books.~~5pt; PADDING-LEFT: 1~~As of March 2006, the Bookshelf had 55 titles covering aspects of molecular biology, biochemistry, cell biology, genetics, microbiology, a couple of disease states from a molecular and cellular point of view, research methods, and virology. Some of the books are online versions of previously published books, while others, such as Coffee Break (book), are written and edited by NCBI staff.~~5pt; BACKGROUND: white; BORDER~~The Bookshelf is a complement to the Entrez PubMed repository of peer-~~BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1~~reviewed publication abstracts in that Bookshelf contents provide established perspectives on evolving areas of study and a context in which many disparate individual pieces of reported research can be organized.~~5pt~~  ~~BORDER~~ See<~~p class~~/font> also<~~span lang="EN-US" style="FONT-SIZE: 9pt; COLOR: #504f47; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-~~/font~~-kerning: 0pt"~~>~~Pubmed~~ <~~/td~~ul> <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"li>National Institutes of Health </li> <li>United States National Library of Medicine </li> <li>Medline </li> <~~p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; WORD-BREAK: keep-all; LINE-HEIGHT: 13pt; TEXT-AUTOSPACE: ideograph-numeric; TEXT-ALIGN: left; mso-pagination: widow-orphan" align="left"~~li>Entrez <~~span style="FONT-SIZE: 9pt; COLOR: #504f47; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-font-kerning: 0pt">생물~~/li> <~~span lang="EN-US"~~li>/ PubMed </~~span~~li>~~의학 관련 서지정보 [[데이터베이스]]~~ <~~span lang="EN-US"~~li>GenBank </~~span~~li> <~~/span~~li>[[Bioinformatics]] </pli> <~~/td~~li> [[Omics]] </trli> <~~tr style="mso-yfti-irow: 2"~~li>[[Genomics]] </li> <li>[[BLAST]] </li> <~~td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt~~li>[[FASTA]] </li> <li>[[Homology]] </li> <li>[[Biomatics]]  ~~BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8~~</li></ul>  ~~PADDING~~<span class="mw-~~BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width~~headline"> <~~p class~~br />External links<ul> <li><~~span lang~~a class="~~EN-US~~external text" ~~style~~title="~~FONT-SIZE~~http: ~~9pt; COLOR: #504f47; FONT-FAMILY~~//www.ncbi.nlm.nih.gov/" rel="nofollow" href="http: ~~굴림; mso-bidi-font-family: 굴림; mso-font-kerning: 0pt~~//www.ncbi.nlm.nih.gov/">~~Nucleotide~~Website for the National Center for Biotechnology Information</~~span~~a></pli> <~~/td~~li> <~~td style~~a class="external text" title="~~BORDER-RIGHT~~http: ~~windowtext 1pt solid; PADDING-RIGHT: 1~~//www.ncbi.nlm.~~5pt; PADDING-LEFT: 1~~nih.~~5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND~~gov/sites/entrez?db=books" rel="nofollow" href="http: ~~white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1~~//www.ncbi.~~5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1~~nlm.~~5pt; mso-border-right-alt: solid windowtext~~ nih.~~5pt">~~gov/sites/entrez?db=books">NCBI Bookshelf Title List</a> </li> <a class="~~MsoNormal~~external text" ~~style~~title="~~MARGIN~~http: ~~0cm 0cm 0pt; WORD-BREAK: keep-all; LINE-HEIGHT: 13pt; TEXT-AUTOSPACE: ideograph-numeric; TEXT-ALIGN: left; mso-pagination: widow-orphan~~//www.ncbi.nlm.nih.gov/sites/entrez" ~~align~~rel="~~left~~nofollow"~~>~~[[GenBank]], [[EMBL]](European Molecular Biology Laboratory), [[DDBJ]](DNA Database of Japan)~~Entrez PubMed</a> </~~span~~li> <~~span style="FONT-SIZE~~li>[http: ~~9pt; COLOR~~//biopedia.org Biopedia.org]: ~~#504f47; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-font-kerning: 0pt"~~The openfree encyclopedia of bioinformatics and biology </li>~~을 포함하는 Nucleotide Database~~ <li>[http:/~~span><~~/~~span>~~personalgenome.net PersonalGenome.net]: openfree Personal Genome Home. </pli> </tdul>  <~~td style="PADDING~~!-~~RIGHT: 1.5pt; PADDING~~-~~LEFT~~Saved in parser cache with key enwiki: ~~1.5pt; BACKGROUND~~pcache: ~~white; BORDER-BOTTOM-COLOR~~idhash: ~~#ece9d8; PADDING~~149306-~~BOTTOM:~~ 0!1~~.5pt; BORDER~~!0!default!!en!2 and timestamp 20080304150207 -~~LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP~~-~~COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"~~> Protein ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> GenBank, EMBL, 및 DDBJ 등에 등록된 [[DNA]] 서열로부터 얻어진 단백질서열을 제공하는 database. ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 4">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> Structure ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 결정체 연구나 [[핵자기공명]] 연구를 통해 얻어진 단백질 구조를 제공. 특히 구조에 대한 data를 기존의 문헌에서 밝혀진 서열 data 등의 정보와 연계시켜 놓은 database. ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 5">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> Genome ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 다양한 [[유전체]], [[염색체]] [[유전자지도]] 등에 대한 정보를 종합적으로 제공 ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 6">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> Population study data sets ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> [[인종학]], [[계통발생학]], [[돌연변이]] 등에서 발생될 수 있는 배열 문제를 다룸 ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 7">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> OMIM <o:p></o:p> ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 인간의 유전자와 유전자 이상 등에 관한 문헌정보 제공, ~~유전자 성 레코드, 유전지도, 데이터베이스를 연결할수 있음<o:p></o:p>~~ ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 8">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> Taxonomy ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 유전학 데이터베이스에서 나타나는 모든 조직체의 분류학 사전 데이터베이스 ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 9">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> ProbeSet ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 유전자 발현 및 핵산혼성화 배열에 유용한 [[probe]]에 대한 정보를 제공 ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 10">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> 3D Domains ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> NCBI에서 제공하는 단백질의 보존된 영역에 대한 3차구조 자료를 제공. ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 11">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt" width="79"> UNiSTS ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; BORDER-BOTTOM-COLOR: #ece9d8; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; mso-border-right-alt: solid windowtext .5pt"> 여러 data sources에서 얻어진 표지인자 및 유전자지도를 통합하여 단일화 시킨 서열인식부위 정보를 제공 ~~</td>~~ ~~</tr>~~ ~~<tr style="mso-yfti-irow: 12; mso-yfti-lastrow: yes">~~ <td style="PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BACKGROUND: white; PADDING-BOTTOM: 1.5pt; BORDER-LEFT: windowtext 1pt solid; WIDTH: 59.15pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-BOTTOM: windowtext 1pt solid; BORDER-RIGHT-COLOR: #ece9d8; mso-border-left-alt: solid windowtext .5pt; mso-border-bottom-alt: solid windowtext .5pt" width="79"> SNP<o:p></o:p> ~~</td>~~ <td style="BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 1.5pt; PADDING-LEFT: 1.5pt; BORDER-LEFT-COLOR: #ece9d8; BACKGROUND: white; PADDING-BOTTOM: 1.5pt; BORDER-TOP-COLOR: #ece9d8; PADDING-TOP: 1.5pt; BORDER-BOTTOM: windowtext 1pt solid; mso-border-right-alt: solid windowtext .5pt; mso-border-bottom-alt: solid windowtext .5pt"> 단일염기다형성 또는 짧은 염기 삭제나 첨가에 의한 다형성에 대한 중심적 정보를 제공 ~~</td>~~ ~~</tr>~~ ~~</tbody></table> #NCBI Handbook <a href="http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=handbook.TOC&depth=2~~printfooter"~~>http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=handbook.TOC&depth=2</a></strong~~></~~fontdiv>

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