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<p><strong>Myxedema</strong> (British English: <strong>myxoedema</strong>) is a skin and tissue disorder usually due to severe prolonged <strong>hypothyroidism</strong>. Hypothyroidism can be caused by Hashimoto's thyroiditis, surgical removal of the thyroid, and rarer conditions. Partial forms of myxedema, especially of the lower legs (called pretibial myxedema), occasionally occur in adults with Graves' disease, a cause of hyperthyroidism; or also Hashimoto's thyroiditis without severe hypothyroidism.</p>
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<p><span class="mw-headline"><font size="5">Symptoms</font></span></p>
<p>Myxedema usually presents itself with some of the following symptoms:</p>
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<li>정의Skin thickening <br /li> <li>Coarse skin </li> <li>Change in facial appearance </li> <li>Thickening nose </li> <li>Swollen lips </li> <li>Puffiness around the eyes </li> <li>Jelly-[[점액수종]]like infiltrations in subcutaneous tissues </li> <li>Slow speech </li> <li>Mental dullness <br /li> <li>-[[갑상선 기능저하증]]의 가장 심한 형태Lethargy </li> <li>Mental problems </ulli> <pli>Dry skin <br /li> <li>Yellow skin <br /li>[[image:점액수종1.jpg]] <li>Swollen subcutaneous tissue <br /li> <li><출처 :Weight gain <font color="#000000"/li> <font size="2"li>www.meddean.luc.edu>Constipation </fontli> <li>Thinning hair <br /li> <li>Brittle hair </fontli> <li>Bald patches <br /li> <li>Muscle pains </pli> <li>Deafness <ul/li> <li>내용Hearing impairment <br /li>-손, 얼굴, 안와 주위 조직의 종창이 특징 <li>Carpal tunnel syndrome </li>
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<p><span class="mw-headline"><font size="5">Causes</font></span></p>
<p>Myxedema stemming from both the hyperthyroid and hypothyroid conditions, results from the accumulation of increased amounts of hyaluronic acid and chondroitin sulfate in the dermis in both lesional and normal skin. The mechanism that causes myxedema is still not yet understood, although animal model studies suggest that thyroid hormones affect the synthesis and catabolism of mucopolysaccharides and collagen by dermal fibroblasts. The fibroblasts in the orbital and pretibial dermis share antigenic sites that underlie the autoimmune process that causes Grave's disease. This cross-reaction may contribute to the development of myxedema long after normal levels of thyroid hormones have been restored by treatment.</p>
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<p><span class="mw-headline"><font size="5">Treatment</font></span></p>
<p>Treatment for myxedema is difficult. Systemic or intralesional glucocorticoids, topical glucocorticoids under occlusion or high-dose intravenous immunoglobulin have been reported to offer some relief to patients. Treatment should follow correction of the original hyperthyroidism/hypothyroidism.</p>
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<p><span class="mw-headline"><font size="5">See also</font></span></p>
<p>Severe hypothyroidism in a child is called Cretinism -<br />
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