Difference between revisions of "Miosis"
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| − | -일반적으로 축동제와 같은 약물로 인해 동공이 작아짐</li> | + | -일반적으로 축동제와 같은 약물로 인해 동공이 작아짐 </li> |
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<p><strong>Miosis</strong> is a medical term for constriction of the <a title="Pupil" href="http://en.wikipedia.org/wiki/Pupil">pupil</a>. It is the opposite of <a title="Mydriasis" href="http://en.wikipedia.org/wiki/Mydriasis">mydriasis</a>. It is seen in a variety of medical conditions, and can also be caused by certain drugs and chemicals. Eye drops used to intentionally cause miosis are known as "miotics". Extreme miosis is commonly called "pinpoint pupils", a situation that can be caused by use of opiates.</p> | <p><strong>Miosis</strong> is a medical term for constriction of the <a title="Pupil" href="http://en.wikipedia.org/wiki/Pupil">pupil</a>. It is the opposite of <a title="Mydriasis" href="http://en.wikipedia.org/wiki/Mydriasis">mydriasis</a>. It is seen in a variety of medical conditions, and can also be caused by certain drugs and chemicals. Eye drops used to intentionally cause miosis are known as "miotics". Extreme miosis is commonly called "pinpoint pupils", a situation that can be caused by use of opiates.</p> | ||
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<p><a id="Physiology_of_the_photomotor_reflex" name="Physiology_of_the_photomotor_reflex"></a></p> | <p><a id="Physiology_of_the_photomotor_reflex" name="Physiology_of_the_photomotor_reflex"></a></p> | ||
| − | <h2 | + | <h2><span class="mw-headline">Physiology of the photomotor reflex</span></h2> |
| − | <p>Visual stimuli enters the eye, and through the retinal photoceptors is converted into an electric impulse, carried through the optic nerve (<a title="Cranial nerve" href="http://en.wikipedia.org/wiki/Cranial_nerve">cranial nerve</a> II) to the brain, where it connects to the pretectal nucleus of the high midbrain. It bypasses the lateral geniculate nucleus and the primary visual cortex. From the pretectal nucleus neurons send axons to neurons of the <a title="Edinger-Westphal nucleus" href="http://en.wikipedia.org/wiki/Edinger-Westphal_nucleus">Edinger-Westphal nucleus</a> whose visceromotor axons run along both the left and right oculomotor nerves. Visceromotor nerve axons (which constitute a portion of the III <a title="Cranial nerve" href="http://en.wikipedia.org/wiki/Cranial_nerve">cranial nerve</a>, along with the somatomotor portion derived from the Edinger-Westphal nucleus) synapse on ciliary ganglion neurons, whose <a title="Parasympathetic" href="http://en.wikipedia.org/wiki/Parasympathetic">parasympathetic</a> axons innervate the constrictor muscle of the iris, producing <strong><strong class="selflink">miosis</strong></strong>. <a | + | <p>Visual stimuli enters the eye, and through the retinal photoceptors is converted into an electric impulse, carried through the optic nerve (<a title="Cranial nerve" href="http://en.wikipedia.org/wiki/Cranial_nerve">cranial nerve</a> II) to the brain, where it connects to the pretectal nucleus of the high midbrain. It bypasses the lateral geniculate nucleus and the primary visual cortex. From the pretectal nucleus neurons send axons to neurons of the <a title="Edinger-Westphal nucleus" href="http://en.wikipedia.org/wiki/Edinger-Westphal_nucleus">Edinger-Westphal nucleus</a> whose visceromotor axons run along both the left and right oculomotor nerves. Visceromotor nerve axons (which constitute a portion of the III <a title="Cranial nerve" href="http://en.wikipedia.org/wiki/Cranial_nerve">cranial nerve</a>, along with the somatomotor portion derived from the Edinger-Westphal nucleus) synapse on ciliary ganglion neurons, whose <a title="Parasympathetic" href="http://en.wikipedia.org/wiki/Parasympathetic">parasympathetic</a> axons innervate the constrictor muscle of the iris, producing <strong><strong class="selflink">miosis</strong></strong>. <a class="external autonumber" title="http://www.coldbacon.com/mdtruth/pics/netter/fn-oculomotor.jpg" rel="nofollow" href="http://www.coldbacon.com/mdtruth/pics/netter/fn-oculomotor.jpg">[1]</a></p> |
<p><a id="Causes" name="Causes"></a></p> | <p><a id="Causes" name="Causes"></a></p> | ||
| − | <h2 | + | <h2><span class="mw-headline">Causes</span></h2> |
<p><a id="Age" name="Age"></a></p> | <p><a id="Age" name="Age"></a></p> | ||
| − | <h3 | + | <h3><span class="mw-headline">Age</span></h3> |
<p>The likelihood of suffering miosis increases with age.</p> | <p>The likelihood of suffering miosis increases with age.</p> | ||
<p><a id="Diseases" name="Diseases"></a></p> | <p><a id="Diseases" name="Diseases"></a></p> | ||
| − | <h3 | + | <h3><span class="mw-headline">Diseases</span></h3> |
<ul> | <ul> | ||
| − | <li><a title="Horner syndrome" href="http://en.wikipedia.org/wiki/Horner_syndrome">Horner syndrome</a> (a set of abnormalities in the nervous supply of the face due to damage to the <a title="Sympathetic nervous system" href="http://en.wikipedia.org/wiki/Sympathetic_nervous_system">sympathetic nervous system</a>).</li> | + | <li><a title="Horner syndrome" href="http://en.wikipedia.org/wiki/Horner_syndrome">Horner syndrome</a> (a set of abnormalities in the nervous supply of the face due to damage to the <a title="Sympathetic nervous system" href="http://en.wikipedia.org/wiki/Sympathetic_nervous_system">sympathetic nervous system</a>). </li> |
| − | <li><a title="Pancoast tumor" href="http://en.wikipedia.org/wiki/Pancoast_tumor">Pancoast tumor</a> (a <a title="Lung cancer" href="http://en.wikipedia.org/wiki/Lung_cancer">tumor</a> of the apical <a title="Lung" href="http://en.wikipedia.org/wiki/Lung">lung</a>), due to damage to the ascending sympathetic tract that would normally cause the pupil to dilate.</li> | + | <li><a title="Pancoast tumor" href="http://en.wikipedia.org/wiki/Pancoast_tumor">Pancoast tumor</a> (a <a title="Lung cancer" href="http://en.wikipedia.org/wiki/Lung_cancer">tumor</a> of the apical <a title="Lung" href="http://en.wikipedia.org/wiki/Lung">lung</a>), due to damage to the ascending sympathetic tract that would normally cause the pupil to dilate. </li> |
| − | <li><a title="Hemorrhage" href="http://en.wikipedia.org/wiki/Hemorrhage">Hemorrhage</a> into <a title="Pons" href="http://en.wikipedia.org/wiki/Pons">pons</a> (<a title="Intracranial hemorrhage" href="http://en.wikipedia.org/wiki/Intracranial_hemorrhage">intracranial hemorrhage</a>)</li> | + | <li><a title="Hemorrhage" href="http://en.wikipedia.org/wiki/Hemorrhage">Hemorrhage</a> into <a title="Pons" href="http://en.wikipedia.org/wiki/Pons">pons</a> (<a title="Intracranial hemorrhage" href="http://en.wikipedia.org/wiki/Intracranial_hemorrhage">intracranial hemorrhage</a>) </li> |
</ul> | </ul> | ||
<p><a id="Drugs" name="Drugs"></a></p> | <p><a id="Drugs" name="Drugs"></a></p> | ||
| − | <h3 | + | <h3><span class="mw-headline">Drugs</span></h3> |
<ul> | <ul> | ||
| − | <li><a title="Opioid" href="http://en.wikipedia.org/wiki/Opioid">Opioids</a> such as <a title="Codeine" href="http://en.wikipedia.org/wiki/Codeine">codeine</a>, <a title="Morphine" href="http://en.wikipedia.org/wiki/Morphine">morphine</a>, <a title="Heroin" href="http://en.wikipedia.org/wiki/Heroin">heroin</a> and <a title="Methadone" href="http://en.wikipedia.org/wiki/Methadone">methadone</a></li> | + | <li><a title="Opioid" href="http://en.wikipedia.org/wiki/Opioid">Opioids</a> such as <a title="Codeine" href="http://en.wikipedia.org/wiki/Codeine">codeine</a>, <a title="Morphine" href="http://en.wikipedia.org/wiki/Morphine">morphine</a>, <a title="Heroin" href="http://en.wikipedia.org/wiki/Heroin">heroin</a> and <a title="Methadone" href="http://en.wikipedia.org/wiki/Methadone">methadone</a> </li> |
| − | <li><a title="Antipsychotics" href="http://en.wikipedia.org/wiki/Antipsychotics">Antipsychotics</a>, including <a title="Haloperidol" href="http://en.wikipedia.org/wiki/Haloperidol">haloperidol</a>, <a title="Thorazine" href="http://en.wikipedia.org/wiki/Thorazine">thorazine</a>, <a title="Olanzapine" href="http://en.wikipedia.org/wiki/Olanzapine">olanzapine</a>, <a title="Quetiapine" href="http://en.wikipedia.org/wiki/Quetiapine">quetiapine</a> and others</li> | + | <li><a title="Antipsychotics" href="http://en.wikipedia.org/wiki/Antipsychotics">Antipsychotics</a>, including <a title="Haloperidol" href="http://en.wikipedia.org/wiki/Haloperidol">haloperidol</a>, <a title="Thorazine" href="http://en.wikipedia.org/wiki/Thorazine">thorazine</a>, <a title="Olanzapine" href="http://en.wikipedia.org/wiki/Olanzapine">olanzapine</a>, <a title="Quetiapine" href="http://en.wikipedia.org/wiki/Quetiapine">quetiapine</a> and others </li> |
| − | <li><a title="Cholinergic" href="http://en.wikipedia.org/wiki/Cholinergic">Cholinergic</a> agents such as those used to treat <a title="Alzheimer's disease" href="http://en.wikipedia.org/wiki/Alzheimer%27s_disease">Alzheimer's disease</a> and <a title="Nerve gas" href="http://en.wikipedia.org/wiki/Nerve_gas">nerve gases</a>; cholinergic drugs such as <a title="Carbachol" href="http://en.wikipedia.org/wiki/Carbachol">carbachol</a> (Miostat) and <a title="Neostigmine" href="http://en.wikipedia.org/wiki/Neostigmine">neostigmine</a></li> | + | <li><a title="Cholinergic" href="http://en.wikipedia.org/wiki/Cholinergic">Cholinergic</a> agents such as those used to treat <a title="Alzheimer's disease" href="http://en.wikipedia.org/wiki/Alzheimer%27s_disease">Alzheimer's disease</a> and <a title="Nerve gas" href="http://en.wikipedia.org/wiki/Nerve_gas">nerve gases</a>; cholinergic drugs such as <a title="Carbachol" href="http://en.wikipedia.org/wiki/Carbachol">carbachol</a> (Miostat) and <a title="Neostigmine" href="http://en.wikipedia.org/wiki/Neostigmine">neostigmine</a> </li> |
| − | <li>Some cancer <a title="Chemotherapy" href="http://en.wikipedia.org/wiki/Chemotherapy">chemotherapy</a> drugs, including <a title="Camptothecin" href="http://en.wikipedia.org/wiki/Camptothecin">camptothecin</a> derivatives</li> | + | <li>Some cancer <a title="Chemotherapy" href="http://en.wikipedia.org/wiki/Chemotherapy">chemotherapy</a> drugs, including <a title="Camptothecin" href="http://en.wikipedia.org/wiki/Camptothecin">camptothecin</a> derivatives </li> |
| − | <li><a title="Mirtazapine" href="http://en.wikipedia.org/wiki/Mirtazapine">Mirtazapine</a>, a <a title="Noradrenergic and specific serotonergic antidepressant" href="http://en.wikipedia.org/wiki/Noradrenergic_and_specific_serotonergic_antidepressant">noradrenergic and specific serotonergic antidepressant</a> (<a title="NaSSA" href="http://en.wikipedia.org/wiki/NaSSA">NaSSA</a>)</li> | + | <li><a title="Mirtazapine" href="http://en.wikipedia.org/wiki/Mirtazapine">Mirtazapine</a>, a <a title="Noradrenergic and specific serotonergic antidepressant" href="http://en.wikipedia.org/wiki/Noradrenergic_and_specific_serotonergic_antidepressant">noradrenergic and specific serotonergic antidepressant</a> (<a title="NaSSA" href="http://en.wikipedia.org/wiki/NaSSA">NaSSA</a>) </li> |
| − | <li><a title="Trazadone" href="http://en.wikipedia.org/wiki/Trazadone">Trazadone</a></li> | + | <li><a title="Trazadone" href="http://en.wikipedia.org/wiki/Trazadone">Trazadone</a> </li> |
| − | <li><a title="Alcohol" href="http://en.wikipedia.org/wiki/Alcohol">Alcohol</a></li> | + | <li><a title="Alcohol" href="http://en.wikipedia.org/wiki/Alcohol">Alcohol</a> </li> |
</ul> | </ul> | ||
<p><a id="Miotics" name="Miotics"></a></p> | <p><a id="Miotics" name="Miotics"></a></p> | ||
| − | <h3 | + | <h3><span class="mw-headline">Miotics</span></h3> |
<p>A <strong>miotic</strong> substance causes the constriction of the <a title="Pupil" href="http://en.wikipedia.org/wiki/Pupil">pupil</a> of the eye (or <strong class="selflink">miosis</strong>). It is the opposite of a <a title="Mydriatic" href="http://en.wikipedia.org/wiki/Mydriatic">Mydriatic</a> substance, which causes <a title="Dilation" href="http://en.wikipedia.org/wiki/Dilation">dilation</a> of the pupil.</p> | <p>A <strong>miotic</strong> substance causes the constriction of the <a title="Pupil" href="http://en.wikipedia.org/wiki/Pupil">pupil</a> of the eye (or <strong class="selflink">miosis</strong>). It is the opposite of a <a title="Mydriatic" href="http://en.wikipedia.org/wiki/Mydriatic">Mydriatic</a> substance, which causes <a title="Dilation" href="http://en.wikipedia.org/wiki/Dilation">dilation</a> of the pupil.</p> | ||
<p><a id="External_links" name="External_links"></a></p> | <p><a id="External_links" name="External_links"></a></p> | ||
| − | <h2 | + | <h2><span class="mw-headline">External links</span></h2> |
<ul> | <ul> | ||
| − | <li><a | + | <li><a class="external text" title="http://www.fpnotebook.com/EYE35.htm" rel="nofollow" href="http://www.fpnotebook.com/EYE35.htm">FP Notebook</a> </li> |
| − | <li><em><a | + | <li><em><a class="external text" title="http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1254817782" rel="nofollow" href="http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1254817782">-1254817782</a></em> at <a title="GPnotebook" href="http://en.wikipedia.org/wiki/GPnotebook">GPnotebook</a> </li> |
</ul> | </ul> | ||
Revision as of 08:41, 21 August 2007
- 정의
-동공이 작아지는 상태
- 내용
-일반적으로 축동제와 같은 약물로 인해 동공이 작아짐
Miosis is a medical term for constriction of the pupil. It is the opposite of mydriasis. It is seen in a variety of medical conditions, and can also be caused by certain drugs and chemicals. Eye drops used to intentionally cause miosis are known as "miotics". Extreme miosis is commonly called "pinpoint pupils", a situation that can be caused by use of opiates.
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Contents
Physiology of the photomotor reflex
Visual stimuli enters the eye, and through the retinal photoceptors is converted into an electric impulse, carried through the optic nerve (cranial nerve II) to the brain, where it connects to the pretectal nucleus of the high midbrain. It bypasses the lateral geniculate nucleus and the primary visual cortex. From the pretectal nucleus neurons send axons to neurons of the Edinger-Westphal nucleus whose visceromotor axons run along both the left and right oculomotor nerves. Visceromotor nerve axons (which constitute a portion of the III cranial nerve, along with the somatomotor portion derived from the Edinger-Westphal nucleus) synapse on ciliary ganglion neurons, whose parasympathetic axons innervate the constrictor muscle of the iris, producing miosis. [1]
Causes
Age
The likelihood of suffering miosis increases with age.
Diseases
- Horner syndrome (a set of abnormalities in the nervous supply of the face due to damage to the sympathetic nervous system).
- Pancoast tumor (a tumor of the apical lung), due to damage to the ascending sympathetic tract that would normally cause the pupil to dilate.
- Hemorrhage into pons (intracranial hemorrhage)
Drugs
- Opioids such as codeine, morphine, heroin and methadone
- Antipsychotics, including haloperidol, thorazine, olanzapine, quetiapine and others
- Cholinergic agents such as those used to treat Alzheimer's disease and nerve gases; cholinergic drugs such as carbachol (Miostat) and neostigmine
- Some cancer chemotherapy drugs, including camptothecin derivatives
- Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA)
- Trazadone
- Alcohol
Miotics
A miotic substance causes the constriction of the pupil of the eye (or miosis). It is the opposite of a Mydriatic substance, which causes dilation of the pupil.
![[1]](http://www.coldbacon.com/mdtruth/pics/netter/fn-oculomotor.jpg){kind=link}