Changes

<td>&nbsp;110</td> <td>&nbsp;CD61A, GPⅡb/Ⅲa, &beta;3 integrin chainCarbohydrate antigen</td> <td>&nbsp;PlateletsB cells, megakaryocytes, macrophagessubpopulation of T cells&nbsp;</td> <td>&nbsp;Integrin subunit, associates with CD41 (Gp11b/11a) or CD51 (vironectin receptor)Not known&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;140</td> <td bgcolor="#cccccc">&nbsp;E-selectinPk blood group antigen, Burkitt's lymphoma antigen, (BLA), ELAM-1ceramide trihexoside (CTH), LECAM-2globotriaosylceramide (Gb3); sphingolipid antigen&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Germinal-center B cells&nbsp;Acutely activated endothelium, chronic inflammatory lesions of skin and synovium&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Adhesion molecule that mediates leukocyte rolling on activated endothelium at inflammatory sitesNot known&nbsp;</td>

<td>&nbsp;6540-45</td> <td>&nbsp;LIg-selectin&alpha;, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1MB1&nbsp;</td> <td>&nbsp;Most peripheral-blood B cells, T cells, monocytes, granulocytes, NK cells&nbsp; bone-marrow lymphocytes and myeloid cells, thymocytes</td> <td>&nbsp;Adhesion molecule that mediates lymphocyte homing Component of B-cell antigen receptor analogous to high endothelial venules of peripheral lymphoid tissue &nbsp;CD3, required for cell-surface expression and leukocyte rolling on activated endothelium at inflammatory sitessignal transduction&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;12037</td> <td bgcolor="#cccccc">&nbsp;P-selectinB29, granule membrane proteinIg-140 (GMP-140), platelet activation-dependent granule-external membrane protein (PADGEM)&beta;&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Endothelium, platelets, megakaryocytesB cells&nbsp; </td> <td bgcolor="#cccccc">&nbsp;Interaction with PSGLComponent of B-1 cell antigen receptor analogous to mediate tethering and rolling of leukocytes on the CE3, required for cell-surface of activated endothelial cells, the first step in leukocyte extravasation expression and migration toward sites of inflammationsignal transduction&nbsp;</td>

<td>&nbsp;40-60</td> <td>&nbsp;B7, B7.1, BB1&nbsp;LIMP, MLA1, PTLGP40, gp55, granulophysin lysosomal-membrane-associated glycoprotein 3 (LAMP-3), melanoma-associated antigen (ME491), neuroglandular antigen (NGA)</td> <td>&nbsp;Platelets, endothelium, degranulated neutrophils, monocytes, Activated B and T cells; macrophages endothelium&nbsp;</td> <td>&nbsp;Not knownCo-stimulation of T-cell activation with CD86&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;7226</td> <td bgcolor="#cccccc">&nbsp;FcTarget for anti-proliferative antigen-1 (TAPA-1)&gammanbsp;\RI, FCRI</td> <td bgcolor="#cccccc">&nbsp;MonocytesBroadly expressed on hematopoeitic cells; expressed by endothelial and epithelial cells; absent from erythrocytes, macrophagesplatelets, bood and germinal-center dendritic cells, PMN activated by IFN-neutrophils&gammanbsp; or G-CSF, early myeloid-lineage cells</td> <td bgcolor="#cccccc">&nbsp;Phagocytosis: receptorMember of CD19/CD21/Leu-13 signal-mediated endocytosis of IgGtransduction complex, the B-antigen complexes; antigen capture for presentation to T cells; antibodycell co-dependent cellular cytotoxicity; mediator of release by some cells of cytokines and reactive oxygen intermediatesreceptor</td>

<td>&nbsp;45-90</td> <td>&nbsp;Ceramide-dodecasaccharide4F9, C33, IA4, KAI1, VIM-2; glycolipidR2&nbsp;</td> <td>&nbsp;Myeloid Activated/differentiated hematopoeitic cells&nbsp;</td> <td>&nbsp;Not knownSignal transduction: may induce T-cell spreading and pseudopod formation, modulate T-cell proliferation, and provide co-stimulatory signals for cytokine production; possible role in activation of monocytes&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;43</td> <td bgcolor="#cccccc">&nbsp;Sialylated-CD65, VIM-2; carbohydrateHB15&nbsp;</td> <td bgcolor="#cccccc">&nbsp;GranulocytesDendritic cells, B cells, monocytesLangerhans cells&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Possible involvement with phagocytosis and Ca 2+ influxNot known&nbsp;</td>

<td>&nbsp;160-18073</td> <td>&nbsp;NCA-160, biliary glycoprotein (BGP)GR6&nbsp;</td> <td>&nbsp;GranulocytesMonocytes, epithelial platelets, circulating B cells&nbsp;</td> <td>&nbsp;Adhesion molecule; receptor for <em>Neisseria gonorrheae</em> and <em>N. meningitidis</em>; trigger of neutrophil activationNot known&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;95-100110</td> <td bgcolor="#cccccc">&nbsp;CD67, CGM6, NCA-95GR4&nbsp;</td> <td bgcolor="#cccccc">&nbsp;GranulocytesPlasma cells, mantle-zone and germinal-center B cells, subpopulation of peripheral-blood NK cells&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Adhesion moleculePossible role in T-cell activation in peripheral&nbsp; trigger of neutrophil activationblood&nbsp;</td>

<td>&nbsp;9080</td> <td>&nbsp;NCA, NCA-50/90B7.2&nbsp;</td> <td>&nbsp;GranulocytesDendritic cells, epithelial memory B cells, germinal-center&nbsp;B cells, monocytes&nbsp;</td> <td>&nbsp;Adhesion Major T cell costimulatory molecule; trigger of neutrophil activation, interacting with CD28 (stimulatory) and CTLA4 (inhibitory)&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;3041-68, 35-39</td> <td bgcolor="#cccccc">&nbsp;CGM1Urokinase plasminogen activator receptor (uPAR)&nbsp;</td> <td bgcolor="#cccccc">&nbsp;GranulocytesT cells, NK cells, monocytes, neutrophils; non-hematopoeitic cells such as vascular endothelial cells, fibroblasts, smooth muscle cells, keratinocytes, placental trophoblasts, hepatocytes&nbsp;</td> <td bgcolor="#cccccc">&nbsp;UnclearReceptor for uPA, which can convert plasminogen to plasmin; possible role in &beta; receptor for <em>Neisseria gonorrheae 2 integrin-dependent adherence and N. meningitidis</em>chemotaxis</td>

<td>&nbsp;180-20043</td> <td>&nbsp;Carcinoembryonic antigen (CEA)&nbsp;C5a receptor, C5aR</td> <td>&nbsp;Epithelial Granulocytes, monocytes, dendritic cells&nbsp;</td> <td>&nbsp;UnclearC5a-mediated inflammation; possible adhesion moleculeactivation of granulocytes&nbsp;</td>

<td bgcolor="#cccccc">&nbsp;5445-7270, 55-75, 70-100, 50-65</td> <td bgcolor="#cccccc">&nbsp;PregnancyFc&alpha;-specific b1 glycoprotein, SP-1, pregnancy-specific glycoprotein receptor R (PSG)Fc&nbspalpha;-R), IgA Fc receptor, IgA receptor</td> <td bgcolor="#cccccc">&nbsp;Fetal liverMyeloid-lineage cells from promyelocytes to neutrophils and from promonocyte to monocytes; produced in placenta activated eosinophils, alveolar and releasedsplenic macrophages&nbsp;</td> <td bgcolor="#cccccc">&nbsp;Unclear;&nbsp;possible involvement in immune regulation and protection Induction of phagocytosis, degranulation, respiratory burst, killing of fetus from maternal immune system; necessary for successful pregnancymicroorganisms&nbsp;</td>

<td>&nbsp;11025-35</td> <td>&nbsp;gp110, macrosialinThy-1&nbsp;</td> <td>&nbsp;Monocytes, macrophages, dendritic Hematopoeitic stem cells, neutrophilsthymocytes, basophils, mast cells, myeloid progenitor cells, subset of CD34+ hematopoeitic progenitor cells, activated peripheral T cells, some peropheral-blood B cellshuman node HEV endothelium&nbsp;</td> <td>&nbsp;Not knownPossible involvement in lymphocyte co-stimulation; possible inhibition of proliferation and&nbsp;differentiation of hematopoeitic stem cells&nbsp;</td>