CD46-60

CD antigen	MW.(kDa)	Synonyms & Properties	Leukocyte expression	Function
CD46	52-58, 35-40	Membrane cofactor protein (MCP)	Peripheral-blood lymphocytes (PBL), non-hematopoeitic tissues such as salivary glands and kidney ducts	Protective barrier against inappropriate complement activation and deposition on plasma membranes
CD47	45-60, 47-55	RH-associated protein, gp42, integrin-associated protein(IAP), neutrophilin, ovarian carcinoma antigen3 (OA3)	Most cells	Adhesion molecule; thrombospondin receptor
CD48	45	BCM1 in mouse, Blast-1, Hu Lym3, OX-45 in rat	All leukocytes except neutrophils	Adhesion molecule via its receptor, CD2
CD49a	200	α-1 integrin chain, very late antigen α 1 chain (VLA-1 α chain)	Activated T cells, monocytes, neuronal cells, smooth muscles	Integrin that associates with CD29, binds collagen, laminin-1
CD49b	160	α-2 integrin chain, GPIa VLA-2 α chain	B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts	Integrin that associates with CD29, binds collagen, laminin-1
CD49c	125, 30	α-3 integrin chain, VLA-3 α chain	B cells, many adherent cells	Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin
CD49d	145	α-4 integrin chain, VLA-4 α chain	Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils	Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (α4β1 and α4β7) and MAdCAM-1(α4β7) and attachment to extracellular matrix proteins fibronectin (α4β1 and α4β7) and thrombospondin (α4β1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation
CD49e	135	α-5 integrin chain, FNR α chain, VLA-5 α chain	Many cell types, including memory T cells, monocytes, platelets	Integrin that associates with CD29, binds fibronectin, invasin
CD49f	40-52	Bp50	B cells, T cells, neutrophils, granulocytes, monocytes	Role in signal transduction
CD50	48 (monomer)	Bp50	B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors	Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells
CD51	αβ dimer: α, 125; β, 122	GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa	Platelets, megakaryocytes	Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin
CD52	a, 23;   b, 135,23;   c, 22;	a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV	Platelets, megakaryocytes	Adhesion of platelets to endothelium; amplification of platelet response to thrombin
CD53	95-115 in  T cells, 115-135 in neutrophils	gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin	All leukocytes except most resting B cells	Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells
CD54	85	ECMR Ⅲ, H-CAM, HUTCH-1, Hermes, Lu, Pgp-1, gp85	Surface of most cell types	Adhesion molecule mediating leukocyte attachment and homing to peripheral lymphoid organs and sites of inflammation
CD55	85-250 in epithelial cells; 85-200 in lymphocytes	CD44v, CD44v9; heterogenous group of CD44 variant isoforms designated by the variant exons that they include (v2-v10 in humans)	Epithelial cells and monocytes (constitutively), activated leukocytes	Possible role (particulary for CD44v6) in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation
CD56	210, 220, 180, 200	Leukocyte common antigen (LCA), T200, EC 3.1.3.4; many dofferent isoforms with different molecular weights, e.g.. B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO	All hematopoeitic cells; different isoforms characteristic of differentiated subsets of various hematopoeitic cells	Essential role in T-and B-cell antigen-receptor-mediated activation; possible role in receptor-mediated activation in other leukocytes
CD57
CD58
CD59
CDw60