Difference between revisions of "Cell Cycle : G1/S Check point"
From Opengenome.net
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− | <a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif</a> | + | <a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif</a> <br /> |
+ | <br /> | ||
+ | <table style="WIDTH: 767px; HEIGHT: 513px" cellspacing="1" cellpadding="1" width="767" summary="" border="1"> | ||
+ | <tbody> | ||
+ | <tr> | ||
+ | <td> </td> | ||
+ | <td> </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">SMAD3</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">SMAD4</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">SMAD3</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">TGFb</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">ATM</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">ATR</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">ATM</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">p53</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">RB</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">ABL</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">RB</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">HDAC</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">RB</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">E2F-1</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">CDK2</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">Cyclind-CDK4-CDK6</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">CDK4</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">CDK6</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">CDK4</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">Cyclin D</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">SKP2</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">p21 ubiquitination</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">HDAC</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">RB</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">TGBF1</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">SMAD3-SMAD4 complex</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">TGBF1</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">E2F-1</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">CDC25A</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">CDK2-Cyclin E complex</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">CDC25A</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">CDK6-CDK4-Cyclin D complex</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">GSK3B</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">Growth Factor with drawal</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">Cyclin D</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">CDK4-CDK6 complex</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">TP53</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">ATM-ATR complex</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">TP53</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">p21</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">TFDP1</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">E2F-1</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">ART</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">ATM</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | <tr> | ||
+ | <td> | ||
+ | <p align="center">ART</p> | ||
+ | </td> | ||
+ | <td> | ||
+ | <p align="center">p53</p> | ||
+ | </td> | ||
+ | </tr> | ||
+ | </tbody> | ||
+ | </table> | ||
+ | <br /> | ||
+ | <br /> | ||
+ | Transcription factor<br /> | ||
+ | -TP53, TFDP1, E2F-1, RB |
Latest revision as of 21:58, 27 August 2006
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif
SMAD3 |
SMAD4 |
SMAD3 |
TGFb |
ATM |
ATR |
ATM |
p53 |
RB |
ABL |
RB |
HDAC |
RB |
E2F-1 |
CDK2 |
Cyclind-CDK4-CDK6 |
CDK4 |
CDK6 |
CDK4 |
Cyclin D |
SKP2 |
p21 ubiquitination |
HDAC |
RB |
TGBF1 |
SMAD3-SMAD4 complex |
TGBF1 |
E2F-1 |
CDC25A |
CDK2-Cyclin E complex |
CDC25A |
CDK6-CDK4-Cyclin D complex |
GSK3B |
Growth Factor with drawal |
Cyclin D |
CDK4-CDK6 complex |
TP53 |
ATM-ATR complex |
TP53 |
p21 |
TFDP1 |
E2F-1 |
ART |
ATM |
ART |
p53 |
Transcription factor
-TP53, TFDP1, E2F-1, RB