<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_g1Pathway.gif</a>&nbsp;<br /><br /><table style="WIDTH: 767px; HEIGHT: 513px" cellspacing="1" cellpadding="1" width="767" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">SMAD3</p> </td> <td> <p align="center">SMAD4</p> </td> </tr> <tr> <td> <p align="center">SMAD3</p> </td> <td> <p align="center">TGFb</p> </td> </tr> <tr> <td> <p align="center">ATM</p> </td> <td> <p align="center">ATR</p> </td> </tr> <tr> <td> <p align="center">ATM</p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">RB</p> </td> <td> <p align="center">ABL</p> </td> </tr> <tr> <td> <p align="center">RB</p> </td> <td> <p align="center">HDAC</p> </td> </tr> <tr> <td> <p align="center">RB</p> </td> <td> <p align="center">E2F-1</p> </td> </tr> <tr> <td> <p align="center">CDK2</p> </td> <td> <p align="center">Cyclind-CDK4-CDK6</p> </td> </tr> <tr> <td> <p align="center">CDK4</p> </td> <td> <p align="center">CDK6</p> </td> </tr> <tr> <td> <p align="center">CDK4</p> </td> <td> <p align="center">Cyclin D</p> </td> </tr> <tr> <td> <p align="center">SKP2</p> </td> <td> <p align="center">p21 ubiquitination</p> </td> </tr> <tr> <td> <p align="center">HDAC</p> </td> <td> <p align="center">RB</p> </td> </tr> <tr> <td> <p align="center">TGBF1</p> </td> <td> <p align="center">SMAD3-SMAD4 complex</p> </td> </tr> <tr> <td> <p align="center">TGBF1</p> </td> <td> <p align="center">E2F-1</p> </td> </tr> <tr> <td> <p align="center">CDC25A</p> </td> <td> <p align="center">CDK2-Cyclin E complex</p> </td> </tr> <tr> <td> <p align="center">CDC25A</p> </td> <td> <p align="center">CDK6-CDK4-Cyclin D complex</p> </td> </tr> <tr> <td> <p align="center">GSK3B</p> </td> <td> <p align="center">Growth Factor with drawal</p> </td> </tr> <tr> <td> <p align="center">Cyclin D</p> </td> <td> <p align="center">CDK4-CDK6 complex</p> </td> </tr> <tr> <td> <p align="center">TP53</p> </td> <td> <p align="center">ATM-ATR complex</p> </td> </tr> <tr> <td> <p align="center">TP53</p> </td> <td> <p align="center">p21</p> </td> </tr> <tr> <td> <p align="center">TFDP1</p> </td> <td> <p align="center">E2F-1</p> </td> </tr> <tr> <td> <p align="center">ART</p> </td> <td> <p align="center">ATM</p> </td> </tr> <tr> <td> <p align="center">ART</p> </td> <td> <p align="center">p53</p> </td> </tr> </tbody></table><br /><br />Transcription factor<br />-TP53, TFDP1, E2F-1, RB