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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_bcrPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_bcrPathway.gif</a><br /><br />Significant progress는 B lymphocyte immune function을 조절하는 본질적인 molecular processes의 외형을 따라서 만들어진다. <br />최근에 관찰되어진 내용을 보면, development동안 발현되어진 다른 종류의 precursor complexes와 충분히 발달된 B cell antigen receptor(BCR) 복합체로부터 발산된 내부의 신호를 전달하는 것의 명백한 화면을 볼 수 있다. 이러한 연구는 또한 BCR-dependent signaling pathways의 섞인 활성에 의해서 영향을 받는 antigenic challenge를 주는 net function을 나타낸다.<br /><br />Pathway Interaction<br /><table style="WIDTH: 701px; HEIGHT: 483px" cellspacing="1" cellpadding="1" width="701" summary="" border="1"> <tbody> <tr> <td> </td> <td> </td> </tr> <tr> <td> <p align="center">SYK</p> </td> <td> <p align="center">BCR</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">SHC</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">VAV</p> </td> </tr> <tr> <td> <p align="center">SHC</p> </td> <td> <p align="center">SYK</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">GRB2</p> </td> </tr> <tr> <td> <p align="center">SOS1</p> </td> <td> <p align="center">GRB2</p> </td> </tr> <tr> <td> <p align="center">VAV</p> </td> <td> <p align="center">SLP65/BLNK</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">RAC1</p> </td> </tr> <tr> <td> <p align="center">RAC1</p> </td> <td> <p align="center">MEKK</p> </td> </tr> <tr> <td> <p align="center">RAF1</p> </td> <td> <p align="center">MEK</p> </td> </tr> <tr> <td> <p align="center">LYN</p> </td> <td> <p align="center">SLP65/BLNK</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">SYK</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BCR</p> </td> </tr> <tr> <td> <p align="center">FOS</p> </td> <td> <p align="center">JUN</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">JNK</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">p38</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">ERK-P</p> </td> </tr> <tr> <td> <p align="center">JUN</p> </td> <td> <p align="center">FOS</p> </td> </tr> <tr> <td> <p align="center">NFATC</p> </td> <td> <p align="center">JUN-FOS</p> </td> </tr> <tr> <td> <p align="center">ELK-1</p> </td> <td> <p align="center">PKC</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">AP-1</p> </td> </tr> <tr> <td> <p align="center">PKC</p> </td> <td> <p align="center">DG</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">ELK-1</p> </td> </tr> </tbody></table>