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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_DNAfragmentPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_DNAfragmentPathway.gif</a><br /><br />Apoptotic cell death는 많은 different cellular stimuli에 의해서 반응이 일어날 수 있는데, 결과적으로 apoptotic signaling pathway는 caspases(See Caspase Cascade pathway)와 mitochondria(See Role of Mitochondria in Apoptotic Signaling pathway)를 포함하는 것의 활성으로 나타난다. 세포를 알아보는 방법으로 apoptosis의 characteristic은 nucleosomal ladder를 생성하는 nuclear genome의 단편으로부터 알아볼 수 있다. 이러한 활성은 apoptotic signaling pathways에 의한 multiple nucleases에 의해서 인도되어진다.<br />Pathway Interaction<br /><table style="WIDTH: 788px; HEIGHT: 579px" cellspacing="1" cellpadding="1" width="788" summary="" border="1"> <tbody> <tr> <td> </td> <td> </td> </tr> <tr> <td> <p align="center">BAX</p> </td> <td> <p align="center">BID</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BCL-2</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BCL-XL</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">BAD</p> </td> <td> <p align="center">AKT pathway</p> </td> </tr> <tr> <td> <p align="center">AKT</p> </td> <td> <p align="center">BAD</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Pro-CASPASE</p> </td> </tr> <tr> <td> <p align="center">APAF-1</p> </td> <td> <p align="center">Cytochrome C</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">pro-caspase 9</p> </td> </tr> <tr> <td> <p align="center">BCL2</p> </td> <td> <p align="center">BCL-KL</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BAX</p> </td> </tr> <tr> <td> <p align="center">TLN</p> </td> <td> <p align="center">PAXILLIN</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">PKC</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">EIF2a</p> </td> </tr> <tr> <td> <p align="center">EIF2a</p> </td> <td> <p align="center">STAT1</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Capases</p> </td> </tr> <tr> <td> <p align="center">ATM</p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">CASP3</p> </td> <td> <p align="center">pro-caspase3</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">caspase6</p> </td> </tr> <tr> <td> <p align="center">CASP7</p> </td> <td> <p align="center">FAK, PKC 등의 Modified signaling</p> </td> </tr> <tr> <td> <p align="center">CYCS</p> </td> <td> <p align="center">ADAF-1</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Pro-caspase 9</p> </td> </tr> <tr> <td> <p align="center">STAT1</p> </td> <td> <p align="center">PAXILLIN</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">EIF2a</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">PARP</p> </td> </tr> <tr> <td> <p align="center">PARP</p> </td> <td> <p align="center">CASPASES</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">STAT1</p> </td> </tr> </tbody></table>
