Changes

<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_aktPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_aktPathway.gif</a><br /><br />많은 cell-surface receptors는 PIP3(Phosphatidylinositol 3,4,5-triphosphate)같은 두번째 messengers의 생성을 포함하는데, 이것은 cell surface로부터 cytoplasm으로 신호를 전달하는 역할을 한다.&nbsp; PIP3 signals는 kinase PDK1(3-phosphoinositide-dipendent protein kinase-1)을 활성화시키고, 이것은 kinase AKT를 다시 활성화시키는데, 또한 이것은 protein kinase B로도 아려져 있다. AKT를 활성화시킴으로써 단백질은 인산화되어지고, cell이 살아남는 것을 촉진시킨다.<br />Pathway Interaction<br /><table style="WIDTH: 633px; HEIGHT: 243px" cellspacing="1" cellpadding="1" width="633" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">AKT</p> </td> <td> <p align="center">hsp90</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">mTOR pathway</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PDK1</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PP2A</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Caspase9</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">FKHRL1</p> </td> </tr> <tr> <td> <p align="center">BAD</p> </td> <td> <p align="center">Cell survival</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Apoptosis</p> </td> </tr> <tr> <td> <p align="center">PI3K</p> </td> <td> <p align="center">GHR</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PIP2</p> </td> </tr> <tr> <td> <p align="center">NFkB</p> </td> <td> <p align="center">IkBa</p> </td> </tr> </tbody></table>