WikiSysop at 12:31, 13 December 2007

2007-12-13T12:31:41Z

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Swiss-Prot is a manually curated biological database of protein sequences. Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.[1] Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.
In 2002, the UniProt consortium was created: it is a collaboration between the Swiss Institute of Bioinformatics, the European Bioinfomatics Institute and the Protein Information Resource (PIR), funded by the National Institutes of Health. Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins.[2] As of 3 April 2007, UniProtKB/Swiss-Prot release 52.2 contains 263,525 entries. As of 3 April 2007, the UniProtKB/TrEMBL release 35.2 contains 4,232,122 entries.
The UniProt consortium produced 3 database components, each optimised for different uses. The UniProt Knowledgebase (UniProtKB (Swiss-Prot + TrEMBL)), the UniProt Non-redundant Reference (UniRef) databases, which combine closely related sequences into a single record to speed similarity searches and the UniProt Archive (UniParc), which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences.
 
<h2>References</h2>
<ol class="references">
<li id="_note-Bairoch2000">^ <cite style="FONT-STYLE: normal">Bairoch Amos (2000). "Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!". Bioinformatics 16: 48-64. PMID 10812477.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%5Bhttp%3A%2F%2Fbioinformatics.oupjournals.org%2Fcgi%2Freprint%2F16%2F1%2F48+Serendipity+in+bioinformatics%2C+the+tribulations+of+a+Swiss+bioinformatician+through+exciting+times%21%5D&rft.jtitle=Bioinformatics&rft.date=2000&rft.volume=16&rft.au=Bairoch+Amos&rft.pages=48-64">  — a historical account by Bairoch. </li>
<li id="_note-0">^ Wu, C.H. et al. (January 2006) "The Universal Protein Resource (UniProt): an expanding universe of protein information.". Nucleic Acids Research, 1;34 (Database issue): D187–91. </li>
</ol>
<ul>
<li>Séverine Altairac, "Naissance d’une banque de données: Interview du prof. Amos Bairoch". Protéines à la Une, August 2006. ISSN 1660-9824. </li>
</ul>
 
<h2>External links</h2>
<ul>
<li><a class="external text" title="http://www.expasy.org/sprot/" href="http://www.expasy.org/sprot/" rel="nofollow">Swiss-Prot Protein Database</a> (Swiss Institute of Bioinformatics) </li>
<li><a class="external text" title="http://www.uniprot.org/" href="http://www.uniprot.org/" rel="nofollow">UniProt</a> (Swiss Institute of Bioinformatics) </li>
</ul>

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Swissprot - Revision history

WikiSysop at 12:31, 13 December 2007