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Porosomes or fusion pores are cup-shaped structures in the cell membranes of eukaryotic cells where vesicles dock in the process of secretion.[1][2] These structures are about 150 nanometers in diameter and contain many different types of protein, especially SNARE proteins that mediate the docking and fusion of the vesicles with the cell membrane. Once the vesicles have docked with the SNARE proteins, they swell, which increases their internal pressure. They then fuse with the membrane, and these pressurized contents are ejected from the cell.[3]
The porosome was discovered in the early to mid 1990's by a team led by Professor Bhanu Jena at Yale University School of Medicine, using atomic force microscopy.[1]
<a id="References" name="References"></a>
<h2>References</h2>
<div class="references-small">
<ol class="references">
<li id="cite_note-Anderson-0">^ <a title="" href="http://en.wikipedia.org/wiki/Porosome#cite_ref-Anderson_0-0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Porosome#cite_ref-Anderson_0-1">b</a> <cite class="Journal" id="CITEREFAnderson_LL2006" style="FONT-STYLE: normal">Anderson LL (2006). "<a class="external text" title="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2006&volume=10&issue=1&spage=126" href="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2006&volume=10&issue=1&spage=126" rel="nofollow">Discovery of the 'porosome'; the universal secretory machinery in cells</a>". J. Cell. Mol. Med. 10 (1): 126–31. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">doi</a>:<a class="external text" title="http://dx.doi.org/10.1111%2Fj.1582-4934.2006.tb00294.x" href="http://dx.doi.org/10.1111%2Fj.1582-4934.2006.tb00294.x" rel="nofollow">10.1111/j.1582-4934.2006.tb00294.x</a>. <a class="external" title="http://www.ncbi.nlm.nih.gov/pubmed/16563225" href="http://www.ncbi.nlm.nih.gov/pubmed/16563225">PMID 16563225</a>. <a class="external free" title="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2006&volume=10&issue=1&spage=126" href="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2006&volume=10&issue=1&spage=126" rel="nofollow">http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2006&volume=10&issue=1&spage=126</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Discovery+of+the+%27porosome%27%3B+the+universal+secretory+machinery+in+cells&rft.jtitle=J.+Cell.+Mol.+Med.&rft.aulast=Anderson+LL&rft.au=Anderson+LL&rft.date=2006&rft.volume=10&rft.issue=1&rft.pages=126%E2%80%9331&rft_id=info:doi/10.1111%2Fj.1582-4934.2006.tb00294.x&rft_id=info:pmid/16563225&rft_id=http%3A%2F%2Fwww.blackwell-synergy.com%2Fopenurl%3Fgenre%3Darticle%26sid%3Dnlm%3Apubmed%26issn%3D1582-1838%26date%3D2006%26volume%3D10%26issue%3D1%26spage%3D126&rfr_id=info:sid/en.wikipedia.org:Porosome">  </li>
<li id="cite_note-1"><a title="" href="http://en.wikipedia.org/wiki/Porosome#cite_ref-1">^</a> <cite class="Journal" id="CITEREFJena_BP2003" style="FONT-STYLE: normal">Jena BP (2003). "<a class="external text" title="http://joe.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=12553865" href="http://joe.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=12553865" rel="nofollow">Fusion pore or porosome: structure and dynamics</a>". J. Endocrinol. 176 (2): 169–74. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">doi</a>:<a class="external text" title="http://dx.doi.org/10.1677%2Fjoe.0.1760169" href="http://dx.doi.org/10.1677%2Fjoe.0.1760169" rel="nofollow">10.1677/joe.0.1760169</a>. <a class="external" title="http://www.ncbi.nlm.nih.gov/pubmed/12553865" href="http://www.ncbi.nlm.nih.gov/pubmed/12553865">PMID 12553865</a>. <a class="external free" title="http://joe.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=12553865" href="http://joe.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=12553865" rel="nofollow">http://joe.endocrinology-journals.org/cgi/pmidlookup?view=long&pmid=12553865</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fusion+pore+or+porosome%3A+structure+and+dynamics&rft.jtitle=J.+Endocrinol.&rft.aulast=Jena+BP&rft.au=Jena+BP&rft.date=2003&rft.volume=176&rft.issue=2&rft.pages=169%E2%80%9374&rft_id=info:doi/10.1677%2Fjoe.0.1760169&rft_id=info:pmid/12553865&rft_id=http%3A%2F%2Fjoe.endocrinology-journals.org%2Fcgi%2Fpmidlookup%3Fview%3Dlong%26pmid%3D12553865&rfr_id=info:sid/en.wikipedia.org:Porosome">  </li>
<li id="cite_note-2"><a title="" href="http://en.wikipedia.org/wiki/Porosome#cite_ref-2">^</a> <cite class="Journal" id="CITEREFJena_BP2004" style="FONT-STYLE: normal">Jena BP (2004). "<a class="external text" title="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2004&volume=8&issue=1&spage=1" href="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2004&volume=8&issue=1&spage=1" rel="nofollow">Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cells</a>". J. Cell. Mol. Med. 8 (1): 1–21. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">doi</a>:<a class="external text" title="http://dx.doi.org/10.1111%2Fj.1582-4934.2004.tb00255.x" href="http://dx.doi.org/10.1111%2Fj.1582-4934.2004.tb00255.x" rel="nofollow">10.1111/j.1582-4934.2004.tb00255.x</a>. <a class="external" title="http://www.ncbi.nlm.nih.gov/pubmed/15090256" href="http://www.ncbi.nlm.nih.gov/pubmed/15090256">PMID 15090256</a>. <a class="external free" title="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2004&volume=8&issue=1&spage=1" href="http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2004&volume=8&issue=1&spage=1" rel="nofollow">http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1582-1838&date=2004&volume=8&issue=1&spage=1</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Discovery+of+the+Porosome%3A+revealing+the+molecular+mechanism+of+secretion+and+membrane+fusion+in+cells&rft.jtitle=J.+Cell.+Mol.+Med.&rft.aulast=Jena+BP&rft.au=Jena+BP&rft.date=2004&rft.volume=8&rft.issue=1&rft.pages=1%E2%80%9321&rft_id=info:doi/10.1111%2Fj.1582-4934.2004.tb00255.x&rft_id=info:pmid/15090256&rft_id=http%3A%2F%2Fwww.blackwell-synergy.com%2Fopenurl%3Fgenre%3Darticle%26sid%3Dnlm%3Apubmed%26issn%3D1582-1838%26date%3D2004%26volume%3D8%26issue%3D1%26spage%3D1&rfr_id=info:sid/en.wikipedia.org:Porosome">  </li>
</ol>
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<a id="External_links" name="External_links"></a>
<h2>External links</h2>
<ul>
<li><a class="external text" title="http://www.med.wayne.edu/physiology/facultyprofile/jena/" href="http://www.med.wayne.edu/physiology/facultyprofile/jena/" rel="nofollow">Molecular Machinery & Mechanism of Cell Secretion</a> Jena Lab at Wayne State University School of Medicine </li>
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 <p><strong>Porosomes</strong> or <strong>fusion pores</strong> are cup-shaped structures in the <font color="#000080">cell membranes</font> of <font color="#000080">eukaryotic</font> cells where <font color="#000080">vesicles</font> dock in the process of <font color="#000080">secretion</font>.<sup class="reference" id="cite_ref-Anderson_0-0"><font color="#000080"><span>[</span>1<span>]</span></font></sup><sup class="reference" id="cite_ref-1"><font color="#000080"><span>[</span>2<span>]</span></font></sup> These structures are about 150 <font color="#000080">nanometers</font> in diameter and contain many different types of protein, especially <font color="#000080">SNARE proteins</font> that mediate the docking and fusion of the vesicles with the cell membrane. Once the vesicles have docked with the SNARE proteins, they swell, which increases their internal pressure. They then fuse with the membrane, and these pressurized contents are ejected from the cell.<sup class="reference" id="cite_ref-2"><font color="#000080"><span>[</span>3<span>]</span></font></sup></p>
 <p>The porosome was discovered in the early to mid 1990's by a team led by Professor Bhanu Jena at <font color="#000080">Yale University</font> School of Medicine, using <font color="#000080">atomic force microscopy</font>.<sup class="reference" id="cite_ref-Anderson_0-1"><font color="#000080"><span>[</span>1<span>]</span></font></sup></p>
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      <li><a class="external text" title="http://www.med.wayne.edu/physiology/facultyprofile/jena/" rel="nofollow" href="http://www.med.wayne.edu/physiology/facultyprofile/jena/"><font color="#000080">Molecular Machinery &amp; Mechanism of Cell Secretion</font></a> Jena Lab at Wayne State University School of Medicine </li>
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Porosome - Revision history

J at 03:02, 9 January 2009

J at 05:14, 6 January 2009

J at 05:14, 6 January 2009