DHEA - Revision history

WikiSysop at 12:47, 25 March 2008

2008-03-25T12:47:02Z

WikiSysop at 12:41, 25 March 2008

2008-03-25T12:41:29Z

WikiSysop at 12:41, 25 March 2008

2008-03-25T12:41:13Z

WikiSysop: Protected "DHEA" [edit=autoconfirmed:move=autoconfirmed]

2008-03-25T12:40:19Z

Protected "DHEA" [edit=autoconfirmed:move=autoconfirmed]

J at 06:32, 22 April 2007

2007-04-22T06:32:54Z

J at 06:31, 22 April 2007

2007-04-22T06:31:00Z

J at 06:29, 22 April 2007

2007-04-22T06:29:50Z

J at 06:19, 22 April 2007

2007-04-22T06:19:13Z

J at 06:15, 22 April 2007

2007-04-22T06:15:31Z

J at 06:14, 22 April 2007

2007-04-22T06:14:55Z

@@ Line 126: / Line 126: @@
 <p>&nbsp;</p>
 <p><span class="mw-headline"><font size="5"><br />
-Effects</font></span></p>
+Beneficial Effects</font></span></p>
 <p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
 <p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>
 <p>Long term supplementation has been shown to improve mood and relieve depression.<sup class="reference" id="_ref-2">[3]</sup></p>
-<p>&nbsp;</p>
+<p>It&nbsp;is suggested that DHEA's beneficial effects&nbsp;arise from its antioxidant, antiobesity, antilipofuscin, antilipidperoxidative and thereby anti-aging actions.&nbsp;<span title="Biogerontology."><a href="javascript:AL_get(this, 'jour', 'Biogerontology.');">Biogerontology.</a></span> 2008 Feb 29<br />
 <p><span class="mw-headline"><font size="4">Disputed effects</font></span></p>
-<p>The significance of the hormone in health and disease is not fully established. It is postulated that DHEA supplements are beneficial in alleviating:</p>
+<p>Hormonal substitution with DHEA, testosterone, and growth hormone is ineffective as anti-aging medicine, while calcium and vitamin d'effectiveness was confirmed in fracture prevention. <span title="Revue médicale suisse."><a href="javascript:AL_get(this, 'jour', 'Rev Med Suisse.');">Rev Med Suisse.</a></span> 2008 Jan 9;4(139):18-20, 22-3<br />
 <ul>
      <li>cardiovascular disease </li>

@@ Line 99: / Line 99: @@
 </table>
 </p>
-<p><span class="mw-headline"><font size="5">Synonyms and brand names</font></span></p>
+<p><span class="mw-headline"><font size="5"><br />
 <p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3&beta;-Hydroxy-5-androsten-17-one; 3&beta;-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>
 <p>Brand names for DHEA include Prastera&reg; and Fidelin&reg;.</p>
 <p>&nbsp;</p>
-<p><span class="mw-headline"><font size="5">DHEAS (Dehydroepiandrosterone sulfate)</font></span></p>
+<p><span class="mw-headline"><font size="5"><br />
 <p><strong>Dehydroepiandrosterone sulfate</strong> (<strong>DHEAS</strong>, PubChem 12594) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation.</p>
 <p>From a practical point measurement of DHEAS is preferable to DHEA as levels are more stable.</p>
 <p>&nbsp;</p>
-<p><span class="mw-headline"><font size="5">Production</font></span></p>
+<p><span class="mw-headline"><font size="5"><br />
 <div class="thumb tright">
 <div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" width="300" longdesc="/wiki/Image:DHEA1.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" />
@@ Line 122: / Line 125: @@
 <p>As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.</p>
 <p>&nbsp;</p>
-<p><span class="mw-headline"><font size="5">Effects</font></span></p>
+<p><span class="mw-headline"><font size="5"><br />
 <p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
 <p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>

@@ Line 99: / Line 99: @@
 </table>
 </p>
-<h2><span class="mw-headline">Synonyms and brand names</span></h2>
+<p><span class="mw-headline"><font size="5">Synonyms and brand names</font></span></p>
 <p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3&beta;-Hydroxy-5-androsten-17-one; 3&beta;-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>
 <p>Brand names for DHEA include Prastera&reg; and Fidelin&reg;.</p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">DHEAS (Dehydroepiandrosterone sulfate)</span></h2>
+<p><span class="mw-headline"><font size="5">DHEAS (Dehydroepiandrosterone sulfate)</font></span></p>
 <p><strong>Dehydroepiandrosterone sulfate</strong> (<strong>DHEAS</strong>, PubChem 12594) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation.</p>
 <p>From a practical point measurement of DHEAS is preferable to DHEA as levels are more stable.</p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Production</span></h2>
+<p><span class="mw-headline"><font size="5">Production</font></span></p>
 <div class="thumb tright">
 <div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" width="300" longdesc="/wiki/Image:DHEA1.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" />
@@ Line 118: / Line 118: @@
 <p>DHEA production is very high during fetal life by the fetal adrenal glands, declines after birth and remains low during childhood. Production begins around 6 years of age, increasing in quantity until peaking in early adulthood, around the age of 25, and declines afterwards to approximately 10% of peak levels by age 80. It is theorized by some that this decline may be due to reduced oxygen and glucose supply to the adrenal glands as a result of age-related atherosclerosis.</p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Role</span></h2>
+<p><span class="mw-headline"><font size="5">Role</font></span></p>
 <p>In a simple view DHEA can be understood as a prohormone for the sex steroids. Its DHEAS variation may be looked at as buffer and reservoir. Its production in the brain suggests that it also has a role as a neurosteroid. As most DHEA is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response. DHEA may have more biologic roles.</p>
 <p>As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.</p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Effects</span></h2>
+<p><span class="mw-headline"><font size="5">Effects</font></span></p>
 <p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
 <p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>
 <p>Long term supplementation has been shown to improve mood and relieve depression.<sup class="reference" id="_ref-2">[3]</sup></p>
 <p>&nbsp;</p>
-<h3><span class="mw-headline">Disputed effects</span></h3>
+<p><span class="mw-headline"><font size="4">Disputed effects</font></span></p>
 <p>The significance of the hormone in health and disease is not fully established. It is postulated that DHEA supplements are beneficial in alleviating:</p>
 <ul>
@@ Line 154: / Line 154: @@
 <p>DHEA and DHEAS are readily available in the United States.</p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Precautions</span></h2>
+<p><span class="mw-headline"><font size="5">Precautions</font></span></p>
 <p>Some assert that DHEA should not be supplemented outside specialist centres under careful observation of experts in the field of endocrinology.</p>
 <p>Side effects may include:</p>
@@ Line 164: / Line 164: @@
 </ul>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Contraindication</span></h2>
+<p><span class="mw-headline"><font size="5">Contraindication</font></span></p>
 <p>As DHEAS and DHEA are converted to sex steroids, their use is contraindicated in patients with any cancer that is estrogen or testosterone dependent.<sup class="noprint Template-Fact"><span title="This claim needs references to reliable sources since February 2007" style="WHITE-SPACE: nowrap">[<em>citation needed</em>]</span></sup></p>
 <p>&nbsp;</p>
-<h2><span class="mw-headline">Increasing endogenous production</span></h2>
+<p><span class="mw-headline"><font size="5">Increasing endogenous production</font></span></p>
 <p>Regular exercise is known to increase DHEA production in the body.<sup class="reference" id="_ref-3">[4]</sup><sup class="reference" id="_ref-4">[5]</sup><sup class="reference" id="_ref-5">[6]</sup> Caloric restriction has also been shown to increase DHEA in primates.<sup class="reference" id="_ref-6">[7]</sup></p>
 <p>&nbsp;</p>

@@ Line 1: / Line 1: @@
-Dehydroepiandrosterone is a steroid hormone, a chemical cousin of testosterone and estrogen.<br />
+Dehydroepiandrosterone is a steroid hormone, a chemical cousin of [[testosterone]] and [[estrogen]].<br />
 <br />
 Study reported in 2006 in <span title="Clinical endocrinology.">Clin Endocrinol.&nbsp;</span>shows that short-term treatment with DHEA increased platelet cGMP production, a marker of NO production, in healthy elderly subjects. This effect is coupled with a decrease in PAI-1 and LDL cholesterol levels as well as an increase in testosterone and E(2) levels. These findings, therefore, suggest that chronic DHEA supplementation would exert antiatherogenic effects, particularly in elderly subjects who display low circulating levels of this hormone.<br />

@@ Line 226: / Line 226: @@
      <li><a class="external text" title="http://www.benbest.com/nutrceut/DHEA.html" rel="nofollow" href="http://www.benbest.com/nutrceut/DHEA.html">DHEA Hormone Replacement at benbest.com</a> </li>
      <li><a class="external text" title="http://skepdic.com/dhea.html" rel="nofollow" href="http://skepdic.com/dhea.html">What the Skeptic's Dictionary has to say on DHEA</a> </li>
-     <li><cite style="FONT-STYLE: normal">Nair K, Rizza R, O'Brien P, Dhatariya K, Short K, Nehra A, Vittone J, Klee G, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall D, Melton L, Smith G, Khosla S, Jensen M (2006). &quot;DHEA in elderly women and DHEA or testosterone in elderly men&quot;. <em>N Engl J Med</em> <strong>355</strong> (16): 1647-59. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889">PMID 17050889</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004%26rft_val_fmt%3Dinfo%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.atitle=DHEA+in+elderly+women+and+DHEA+or+testosterone+in+elderly+men&amp;rft.title=N+Engl+J+Med&amp;rft.jtitle=N+Engl+J+Med&amp;rft.date=2006&amp;rft.volume=355&amp;rft.issue=16&amp;rft.au=Nair+K%2C+Rizza+R%2C+O%27Brien+P%2C+Dhatariya+K%2C+Short+K%2C+Nehra+A%2C+Vittone+J%2C+Klee+G%2C+Basu+A%2C+Basu+R%2C+Cobelli+C%2C+Toffolo+G%2C+Dalla+Man+C%2C+Tindall+D%2C+Melton+L%2C+Smith+G%2C+Khosla+S%2C+Jensen+M&amp;rft.pages=1647-59&amp;rft_id=info:pmid/17050889">&nbsp;</span> <a class="external text" title="http://content.nejm.org/cgi/content/abstract/355/16/1647" rel="nofollow" href="http://content.nejm.org/cgi/content/abstract/355/16/1647">link</a> <br />
+     <li><cite style="FONT-STYLE: normal">Nair K, Rizza R, O'Brien P, Dhatariya K, Short K, Nehra A, Vittone J, Klee G, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall D, Melton L, Smith G, Khosla S, Jensen M (2006). &quot;DHEA in elderly women and DHEA or testosterone in elderly men&quot;. <em>N Engl J Med</em> <strong>355</strong> (16): 1647-59. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889">PMID 17050889</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004%26rft_val_fmt%3Dinfo%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.atitle=DHEA+in+elderly+women+and+DHEA+or+testosterone+in+elderly+men&amp;rft.title=N+Engl+J+Med&amp;rft.jtitle=N+Engl+J+Med&amp;rft.date=2006&amp;rft.volume=355&amp;rft.issue=16&amp;rft.au=Nair+K%2C+Rizza+R%2C+O%27Brien+P%2C+Dhatariya+K%2C+Short+K%2C+Nehra+A%2C+Vittone+J%2C+Klee+G%2C+Basu+A%2C+Basu+R%2C+Cobelli+C%2C+Toffolo+G%2C+Dalla+Man+C%2C+Tindall+D%2C+Melton+L%2C+Smith+G%2C+Khosla+S%2C+Jensen+M&amp;rft.pages=1647-59&amp;rft_id=info:pmid/17050889">&nbsp;</span> <a class="external text" title="http://content.nejm.org/cgi/content/abstract/355/16/1647" rel="nofollow" href="http://content.nejm.org/cgi/content/abstract/355/16/1647">link</a> </li>
      <br />
      [http://whyfiles.org/051fat_fixes/dhea.html Whyfiles]<br />

← Older revision	Revision as of 12:40, 25 March 2008
(No difference)

@@ Line 11: / Line 11: @@
      <tbody>
          <tr>
-             <td align="center" colspan="2"><a class="image" title="" href="http://en.wikipedia.org/wiki/Image:Dehydroepiandrosterone.png"><img height="118" alt="" src="http://upload.wikimedia.org/wikipedia/en/9/98/Dehydroepiandrosterone.png" width="177" longdesc="/wiki/Image:Dehydroepiandrosterone.png" /></a></td>
+             <td align="center" colspan="2"><a class="image" title="" href="http://en.wikipedia.org/wiki/Image:Dehydroepiandrosterone.png"><img height="118" alt="" width="177" longdesc="/wiki/Image:Dehydroepiandrosterone.png" src="http://upload.wikimedia.org/wikipedia/en/9/98/Dehydroepiandrosterone.png" /></a></td>
          </tr>
          <tr>
@@ Line 29: / Line 29: @@
          <tr>
              <td width="90" bgcolor="#ddeeff"><a title="CAS registry number" href="http://en.wikipedia.org/wiki/CAS_registry_number">CAS number</a></td>
-             <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1" href="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1" rel="nofollow">53-43-0</a></span></td>
+             <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1" rel="nofollow" href="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1">53-43-0</a></span></td>
          </tr>
          <tr>
              <td bgcolor="#ddeeff"><a title="Anatomical Therapeutic Chemical Classification System" href="http://en.wikipedia.org/wiki/Anatomical_Therapeutic_Chemical_Classification_System">ATC code</a></td>
-             <td bgcolor="#eeeeee"><a title="ATC code A14" href="http://en.wikipedia.org/wiki/ATC_code_A14">A14</a><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07" href="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07" rel="nofollow">AA07</a></span></td>
+             <td bgcolor="#eeeeee"><a title="ATC code A14" href="http://en.wikipedia.org/wiki/ATC_code_A14">A14</a><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07" rel="nofollow" href="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07">AA07</a></span></td>
          </tr>
          <tr>
              <td bgcolor="#ddeeff"><a title="PubChem" href="http://en.wikipedia.org/wiki/PubChem">PubChem</a></td>
-             <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76" rel="nofollow">76</a></span></td>
+             <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76" rel="nofollow" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76">76</a></span></td>
          </tr>
          <tr>
@@ Line 191: / Line 191: @@
 <ul>
      <li>Nutrition through the Life Cycle, Judith E. Brown, <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&amp;isbn=0534589863">ISBN 0-534-58986-3</a> </li>
 </ul>
 <p><a id="External_links" name="External_links"></a></p>

@@ Line 7: / Line 7: @@
 Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality. (2006)<br />
 <br />
-<p><strong>Dehydroepiandrosterone</strong> (<strong>DHEA</strong>), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an [[autocrine mechanism]])]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.</p>
+<p><strong>Dehydroepiandrosterone</strong> (<strong>DHEA</strong>), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an [[autocrine mechanism]])]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.<br />
 <h2><span class="mw-headline">Synonyms and brand names</span></h2>
 <p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3&beta;-Hydroxy-5-androsten-17-one; 3&beta;-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>

@@ Line 8: / Line 8: @@
 <br />
 <p><strong>Dehydroepiandrosterone</strong> (<strong>DHEA</strong>), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism)]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.</p>
-<script type="text/javascript">
 <h2><span class="mw-headline">Synonyms and brand names</span></h2>
 <p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3&beta;-Hydroxy-5-androsten-17-one; 3&beta;-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>
@@ Line 24: / Line 19: @@
 <h2><span class="mw-headline">Production</span></h2>
 <div class="thumb tright">
-<div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" width="300" longdesc="/wiki/Image:DHEA1.svg" />
+<div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" width="300" longdesc="/wiki/Image:DHEA1.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" />
 <div class="thumbcaption">
-<div class="magnify" style="FLOAT: right"><img height="11" alt="" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" width="15" /></div>
+<div class="magnify" style="FLOAT: right"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></div>
 Production of DHEA from Cholesterol</div>
 </div>
@@ Line 110: / Line 105: @@
 <h2><span class="mw-headline">External links</span></h2>
 <ul>
-     <li><a class="external text" title="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm" href="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm" rel="nofollow"><em>The DHEA Debate: A critical review of experimental data</em></a> at lef.org (Published 2004){This link is to the web equivalent of an infomercial. <strong>Unreliable sponsored analysis</strong>) </li>
+     <li><a class="external text" title="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm" rel="nofollow" href="http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm"><em>The DHEA Debate: A critical review of experimental data</em></a> at lef.org (Published 2004){This link is to the web equivalent of an infomercial. <strong>Unreliable sponsored analysis</strong>) </li>
-     <li><a class="external text" title="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html" href="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html" rel="nofollow"><em>DHEA: Ignore the Hype</em></a> (Published 1996) at <a title="Quackwatch" href="http://en.wikipedia.org/wiki/Quackwatch">Quackwatch</a> </li>
+     <li><a class="external text" title="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html" rel="nofollow" href="http://www.quackwatch.org/01QuackeryRelatedTopics/dhea.html"><em>DHEA: Ignore the Hype</em></a> (Published 1996) at <a title="Quackwatch" href="http://en.wikipedia.org/wiki/Quackwatch">Quackwatch</a> </li>
-     <li><a class="external text" title="http://www.benbest.com/nutrceut/DHEA.html" href="http://www.benbest.com/nutrceut/DHEA.html" rel="nofollow">DHEA Hormone Replacement at benbest.com</a> </li>
+     <li><a class="external text" title="http://www.benbest.com/nutrceut/DHEA.html" rel="nofollow" href="http://www.benbest.com/nutrceut/DHEA.html">DHEA Hormone Replacement at benbest.com</a> </li>
-     <li><a class="external text" title="http://skepdic.com/dhea.html" href="http://skepdic.com/dhea.html" rel="nofollow">What the Skeptic's Dictionary has to say on DHEA</a> </li>
+     <li><a class="external text" title="http://skepdic.com/dhea.html" rel="nofollow" href="http://skepdic.com/dhea.html">What the Skeptic's Dictionary has to say on DHEA</a> </li>
-     <li><cite style="FONT-STYLE: normal">Nair K, Rizza R, O'Brien P, Dhatariya K, Short K, Nehra A, Vittone J, Klee G, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall D, Melton L, Smith G, Khosla S, Jensen M (2006). &quot;DHEA in elderly women and DHEA or testosterone in elderly men&quot;. <em>N Engl J Med</em> <strong>355</strong> (16): 1647-59. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889">PMID 17050889</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004%26rft_val_fmt%3Dinfo%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.atitle=DHEA+in+elderly+women+and+DHEA+or+testosterone+in+elderly+men&amp;rft.title=N+Engl+J+Med&amp;rft.jtitle=N+Engl+J+Med&amp;rft.date=2006&amp;rft.volume=355&amp;rft.issue=16&amp;rft.au=Nair+K%2C+Rizza+R%2C+O%27Brien+P%2C+Dhatariya+K%2C+Short+K%2C+Nehra+A%2C+Vittone+J%2C+Klee+G%2C+Basu+A%2C+Basu+R%2C+Cobelli+C%2C+Toffolo+G%2C+Dalla+Man+C%2C+Tindall+D%2C+Melton+L%2C+Smith+G%2C+Khosla+S%2C+Jensen+M&amp;rft.pages=1647-59&amp;rft_id=info:pmid/17050889">&nbsp;</span> <a class="external text" title="http://content.nejm.org/cgi/content/abstract/355/16/1647" href="http://content.nejm.org/cgi/content/abstract/355/16/1647" rel="nofollow">link</a> <br />
+     <li><cite style="FONT-STYLE: normal">Nair K, Rizza R, O'Brien P, Dhatariya K, Short K, Nehra A, Vittone J, Klee G, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall D, Melton L, Smith G, Khosla S, Jensen M (2006). &quot;DHEA in elderly women and DHEA or testosterone in elderly men&quot;. <em>N Engl J Med</em> <strong>355</strong> (16): 1647-59. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=17050889">PMID 17050889</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004%26rft_val_fmt%3Dinfo%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.atitle=DHEA+in+elderly+women+and+DHEA+or+testosterone+in+elderly+men&amp;rft.title=N+Engl+J+Med&amp;rft.jtitle=N+Engl+J+Med&amp;rft.date=2006&amp;rft.volume=355&amp;rft.issue=16&amp;rft.au=Nair+K%2C+Rizza+R%2C+O%27Brien+P%2C+Dhatariya+K%2C+Short+K%2C+Nehra+A%2C+Vittone+J%2C+Klee+G%2C+Basu+A%2C+Basu+R%2C+Cobelli+C%2C+Toffolo+G%2C+Dalla+Man+C%2C+Tindall+D%2C+Melton+L%2C+Smith+G%2C+Khosla+S%2C+Jensen+M&amp;rft.pages=1647-59&amp;rft_id=info:pmid/17050889">&nbsp;</span> <a class="external text" title="http://content.nejm.org/cgi/content/abstract/355/16/1647" rel="nofollow" href="http://content.nejm.org/cgi/content/abstract/355/16/1647">link</a> <br />
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