CD46-60 - Revision history

Ihjung at 04:19, 6 September 2006

2006-09-06T04:19:45Z

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Ihjung at 03:52, 6 September 2006

2006-09-06T03:52:49Z

Ihjung at 03:47, 6 September 2006

2006-09-06T03:47:16Z

Ihjung at 03:39, 6 September 2006

2006-09-06T03:39:28Z

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<table style="WIDTH: 740px; HEIGHT: 348px" cellspacing="1" cellpadding="1" width="740" summary="" border="1">
<tbody>
<tr>
<td bgcolor="#999999">
 CD antigen
</td>
<td bgcolor="#999999">
 MW.(kDa)  
</td>
<td bgcolor="#999999">
 Synonyms & Properties
</td>
<td bgcolor="#999999">
 Leukocyte expression  
</td>
<td bgcolor="#999999">
 Function
</td>
</tr>
<tr>
<td> CD46</td>
<td> 52-58, 35-40</td>
<td> Membrane cofactor protein 
(MCP)</td>
<td> Peripheral-blood lymphocytes (PBL), non-hematopoeitic tissues such as salivary glands and kidney ducts</td>
<td> Protective barrier against inappropriate complement activation and deposition on plasma membranes</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD47</td>
<td bgcolor="#cccccc"> 45-60, 47-55</td>
<td bgcolor="#cccccc"> RH-associated protein, gp42, integrin-associated protein(IAP), neutrophilin, ovarian carcinoma antigen3 (OA3)</td>
<td bgcolor="#cccccc"> Most cells</td>
<td bgcolor="#cccccc"> Adhesion molecule; thrombospondin receptor</td>
</tr>
<tr>
<td> CD48</td>
<td> 45</td>
<td> BCM1 in mouse, Blast-1, Hu Lym3, OX-45 in rat</td>
<td> All leukocytes except neutrophils</td>
<td> Adhesion molecule via its receptor, CD2</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD49a</td>
<td bgcolor="#cccccc"> 200</td>
<td bgcolor="#cccccc"> α-1 integrin chain, very late antigen α 1 chain (VLA-1 α chain)</td>
<td bgcolor="#cccccc"> Activated T cells, monocytes, neuronal cells, smooth muscles</td>
<td bgcolor="#cccccc"> Integrin that associates with CD29, binds collagen, laminin-1</td>
</tr>
<tr>
<td> CD49b</td>
<td> 160</td>
<td>  α-2 integrin chain, GPIa VLA-2 α chain</td>
<td> B cells, monocytes, platelets, megakaryocytes; neuronal, epithelial, and endothelial cells; osteoclasts</td>
<td> Integrin that associates with CD29, binds collagen, laminin-1</td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD49c</td>
<td bgcolor="#cccccc"> 88-113 (platelet form)</td>
<td bgcolor="#cccccc"> GPⅢb, GPIV, OKM5-antigen, PASIV  </td>
<td bgcolor="#cccccc"> Platelets, mature monocytes / macrophages, endothelial cells </td>
<td bgcolor="#cccccc"> Adhesion molecule in platelet adhesion and aggregation, and in platelet-monocyte or platelet-tumor cell interaction; molecule for recognition of apoptotic neutrophils; scavenger receptor for oxidized LDL </td>
</tr>
<tr>
<td> CD49d</td>
<td> 40-52</td>
<td> gp52-50</td>
<td> B cells; low levels on T cells, neutrophils, granulocytes, and monocytes </td>
<td> Role in signal transduction </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD49e</td>
<td bgcolor="#cccccc"> 45</td>
<td bgcolor="#cccccc"> T10  </td>
<td bgcolor="#cccccc"> Early-stage B and T cells, germinal-center B cells, plasma cells </td>
<td bgcolor="#cccccc"> NAD glycohydrolase </td>
</tr>
<tr>
<td> CD49f</td>
<td> 40-52</td>
<td> Bp50 </td>
<td> B cells, T cells, neutrophils, granulocytes, monocytes   </td>
<td> Role in signal transduction </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD50</td>
<td bgcolor="#cccccc"> 48 (monomer)</td>
<td bgcolor="#cccccc"> Bp50 </td>
<td bgcolor="#cccccc"> B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors  </td>
<td bgcolor="#cccccc"> Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells</td>
</tr>
<tr>
<td> CD51</td>
<td> αβ dimer: α, 125; β, 122 </td>
<td> GlycoproteinⅡb (GPⅡb) αⅡb integrin chain; forms platelet fibrinogen receptor by association with GP Ⅲa </td>
<td>  Platelets, megakaryocytes</td>
<td> Subunit of platelet fibrinogen receptor, which mediates platelet aggregation by acting as receptor for fibrinogen; possibly also receptor for von Willebrand factor, fibronectin, and thrombospondin </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD52</td>
<td bgcolor="#cccccc"> a, 23;  
 b, 135,23;  
 c, 22;</td>
<td bgcolor="#cccccc"> a, GPIX; b, GPIb-α; c, GPIb-β; d, GPV</td>
<td bgcolor="#cccccc"> Platelets, megakaryocytes </td>
<td bgcolor="#cccccc"> Adhesion of platelets to endothelium; amplification of platelet response to thrombin </td>
</tr>
<tr>
<td> CD53</td>
<td> 95-115 in  
T cells, 115-135 in neutrophils</td>
<td> gpL115, leukocyte sialoglycoprotein, leukosialin, sialophorin </td>
<td> All leukocytes except most resting B cells </td>
<td> Possible anti-adhesive ("barrier") molecule mediating repulsion between leukocytes and other cells </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD54</td>
<td bgcolor="#cccccc"> 85</td>
<td bgcolor="#cccccc"> ECMR Ⅲ, H-CAM, HUTCH-1, Hermes, Lu, Pgp-1, gp85 </td>
<td bgcolor="#cccccc"> Surface of most cell types </td>
<td bgcolor="#cccccc"> Adhesion molecule mediating leukocyte attachment and homing to peripheral lymphoid organs and sites of inflammation </td>
</tr>
<tr>
<td> CD55</td>
<td> 85-250 in epithelial cells; 85-200 in lymphocytes</td>
<td> CD44v, CD44v9; heterogenous group of CD44 variant isoforms designated by the variant exons that they include (v2-v10 in humans) </td>
<td> Epithelial cells and monocytes (constitutively), activated leukocytes </td>
<td> Possible role (particulary for CD44v6) in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD56</td>
<td bgcolor="#cccccc"> 210, 220, 180, 200</td>
<td bgcolor="#cccccc"> Leukocyte common antigen (LCA), T200, EC 3.1.3.4; many dofferent isoforms with different molecular weights, e.g.. 
B220, CD45R, CD45RA, CD45RB, CD45RC, CD45RO </td>
<td bgcolor="#cccccc"> All hematopoeitic cells; different isoforms characteristic of differentiated subsets of various hematopoeitic cells</td>
<td bgcolor="#cccccc"> Essential role in T-and B-cell antigen-receptor-mediated activation; possible role in receptor-mediated activation in other leukocytes </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD57</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD58</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CD59</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
<tr>
<td bgcolor="#cccccc"> CDw60</td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
<td bgcolor="#cccccc"> </td>
</tr>
</tbody>
</table>

@@ Line 77: / Line 77: @@
          <tr>
              <td><strong>&nbsp;CD49f</strong></td>
-             <td>&nbsp;40-52</td>
+             <td>&nbsp;125, 25</td>
-             <td>&nbsp;Bp50&nbsp;</td>
+             <td>&nbsp;&alpha;-6 integrinchain, platelet gpI, VLA-6 &alpha; chain</td>
-             <td>&nbsp;B cells, T cells, neutrophils, granulocytes, monocytes&nbsp;&nbsp; </td>
+             <td>&nbsp;T cells, monocytes, platelets, megakaryocytes, trophoblasts</td>
-             <td>&nbsp;Role in signal transduction&nbsp;</td>
+             <td>&nbsp;Integrin that associates with CD29, binds laminin, invasin, merosine</td>
          </tr>
          <tr>
              <td bgcolor="#cccccc"><strong>&nbsp;CD50</strong></td>
-             <td bgcolor="#cccccc">&nbsp;48 (monomer)</td>
+             <td bgcolor="#cccccc">130</td>
-             <td bgcolor="#cccccc">&nbsp;Bp50&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;Intercellular molecule-3, ICAM-3</td>
-             <td bgcolor="#cccccc">&nbsp;B-lineage cells (pro-B through plasma cells), macrophages, follicular dendritic cells, endothelial cells, fibroblasts, keratinocytes, CD34+ hematopoeitic cell progenitors&nbsp;&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;Leukocytes of all lineages</td>
-             <td bgcolor="#cccccc">&nbsp;Roles in B-cell growth, differentiation, and isotype-switching; apoptosis rescue signal for germinal-center B cells; stimulation of cytokine production in macrophages and dendritic cells; up-regulation of adhesion molecules on dendritic cells</td>
+             <td bgcolor="#cccccc">&nbsp;Co-stimulatory molecule in immune response; regulator of LFA-1/ICAM-1 and integrin-&beta;-dependent adhesion</td>
          </tr>
          <tr>

@@ Line 56: / Line 56: @@
          <tr>
              <td bgcolor="#cccccc"><strong>&nbsp;CD49c</strong></td>
-             <td bgcolor="#cccccc">&nbsp;88-113 (platelet form)</td>
+             <td bgcolor="#cccccc">&nbsp;125, 30 </td>
-             <td bgcolor="#cccccc">&nbsp;GPⅢb, GPIV, OKM5-antigen, PASIV&nbsp; </td>
+             <td bgcolor="#cccccc">&nbsp;&alpha;-3 integrin chain, VLA-3 &alpha; chain</td>
-             <td bgcolor="#cccccc">&nbsp;Platelets, mature monocytes / macrophages, endothelial cells&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;B cells, many adherent cells</td>
-             <td bgcolor="#cccccc">&nbsp;Adhesion molecule in platelet adhesion and aggregation, and in platelet-monocyte or platelet-tumor cell interaction; molecule for&nbsp;recognition of apoptotic neutrophils; scavenger receptor for oxidized LDL&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;Integrin that associates with CD29, binds collagen, laminin-5, fibronectin, entacin, invasin</td>
          </tr>
          <tr>
              <td><strong>&nbsp;CD49d</strong></td>
-             <td>&nbsp;40-52</td>
+             <td>&nbsp;145</td>
-             <td>&nbsp;gp52-50</td>
+             <td>&nbsp;&alpha;-4 integrin chain, VLA-4 &alpha; chain</td>
-             <td>&nbsp;B cells; low levels on T cells, neutrophils, granulocytes, and monocytes&nbsp;</td>
+             <td>&nbsp;Many cell types, including T cells, B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, dendritic cells; not on neutrophils</td>
-             <td>&nbsp;Role in signal transduction&nbsp;</td>
+             <td>&nbsp;Cell adhesion molecule for attachment to cell syrface ligands VCAM-1 (&alpha;4&beta;1 and &alpha;4&beta;7) and MAdCAM-1(&alpha;4&beta;7) and attachment to extracellular matrix proteins fibronectin (&alpha;4&beta;1 and &alpha;4&beta;7) and thrombospondin (&alpha;4&beta;1), and for lymphocyte migration and homing; co-stimulatory molecule for T-cell activation</td>
          </tr>
          <tr>
              <td bgcolor="#cccccc"><strong>&nbsp;CD49e</strong></td>
-             <td bgcolor="#cccccc">&nbsp;45</td>
+             <td bgcolor="#cccccc">&nbsp;135</td>
-             <td bgcolor="#cccccc">&nbsp;T10&nbsp; </td>
+             <td bgcolor="#cccccc">&nbsp;&alpha;-5 integrin chain, FNR &alpha; chain, VLA-5 &alpha; chain</td>
-             <td bgcolor="#cccccc">&nbsp;Early-stage B and T cells, germinal-center B cells, plasma cells&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;Many cell types, including memory T cells, monocytes, platelets</td>
-             <td bgcolor="#cccccc">&nbsp;NAD glycohydrolase&nbsp;</td>
+             <td bgcolor="#cccccc">&nbsp;Integrin that associates with CD29, binds fibronectin, invasin</td>
          </tr>
          <tr>