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한국인 햅맵과제 - Revision history
2026-05-12T08:51:47Z
Revision history for this page on the wiki
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211.211.234.4 at 23:27, 13 April 2006
2006-04-13T23:27:42Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:27, 13 April 2006</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l52" >Line 52:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p></div></td></tr>
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<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div></span<ins class="diffchange diffchange-inline">><br /><!--StartFragment--><font size="3">&nbsp;</font></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0" style="LINE-HEIGHT: 180%; TEXT-ALIGN: left"><span style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; LINE-HEIGHT: 180%; FONT-FAMILY: 휴먼명조,한컴돋움">References</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0" style="LINE-HEIGHT: 180%; TEXT-ALIGN: left"><span style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; LINE-HEIGHT: 180%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Ardlie KG, Kruglyak L, Seielstad M. (2002). Patterns of linkage disequilibrium in the human genome. Nat Rev Genet. (4):299-309. </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Cardon LR, Abecasis GR. (2003). Using haplotype blocks to map human complex trait loci. Trends Genet. 19(3):135-40. Review.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Carlson, C. S. et al. (2003). Additional SNPs and linkage-disequilibrium analyses are necessary for wholegenome association studies in humans. Nature Genet. 33, 518&ndash;521.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Clark AG, Nielsen R, Signorovitch J, Matise TC, Glanowski S, Heil J, Winn-Deen ES, Holden AL, Lai E. (2003). Linkage disequilibrium and inference of ancestral recombination in 538 single-nucleotide polymorphism clusters across the human genome. Am J Hum Genet. 73(2):285-300.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Daly, M. J., Rioux, J. D., Schaffner, S. F., Hudson, T. J. and Lander, E. S. (2001). High-resolution haplotype structure in the human genome. Nature Genetics 29, 229&ndash;232.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, Beare DM, Pabial J, Dibling T, Tinsley E, Kirby S, Carter D, Papaspyridonos M, Livingstone S, Ganske R, Lohmussaar E, Zernant J, Tonisson N, Remm M, Magi R, Puurand T, Vilo J, Kurg A, Rice K, Deloukas P, Mott R, Metspalu A, Bentley DR, Cardon LR, Dunham I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature. 418(6897):544-8. </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Falush D, Stephens M, Pritchard JK (2003). Inference of population structure: Extensions to linked loci and correlated allele frequencies. Genetics.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. (2002). The structure of haplotype blocks in the human genome. 296, 2225-2229. </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Kang HJ, Choi KO, Kim BD, Kim SS, Kim YJ. (2005). FESD: a Functional Element SNPs </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Database in human, Nucleic Acids Research, 33, D518-D522.</span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"> </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Dana C Crawford, Tushar Bhangale, Na Li, Garrett Hellenthal, Mark J Rieder, Deborah A Nickerson &amp; Matthew Stephens. (2004) Evidence for substantial fine-scale variation in recombination rates across the human genome. Nature Genetics, Nat Genet. 36(7):700-706.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Lynn BJ, Stephen PW. (2004). Genetic variation, classification and 'race'. Nature Genetics. 36(11):s28-s33.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Lu X, Niu T, Liu JS. (2003). Haplotype information and linkage disequilibrium mapping for single nucleotide polymorphisms. Genome Res. 13(9):2112-7. </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Phillips MS, Lawrence R, Sachidanandam R, Morris AP, Balding DJ, Donaldson MA, Studebaker JF, Ankener WM, Alfisi SV, Kuo FS, Camisa AL, Pazorov V, Scott KE, Carey BJ, Faith J, Katari G, Bhatti HA, Cyr JM, Derohannessian V, Elosua C, Forman AM, Grecco NM, Hock CR, Kuebler JM, Lathrop JA, Mockler MA, Nachtman EP, Restine SL, Varde SA, Hozza MJ, Gelfand CA, Broxholme J, Abecasis GR, Boyce-Jacino MT, Cardon LR. (2003). Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat Genet. 33(3):382-7.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Pritchard JK, Stephens M, Donnelly P. (2000). Inference of population structure using multilocus genotype data. Genetics, 155:945-959.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. (2001). Linkage disequilibrium in the human genome. Nature. 411(6834):199-204.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Stumpf MP, Goldstein DB. (2003). Demography, recombination hotspot intensity, and the block structure of linkage disequilibrium. Curr Biol. 13(1):1-8.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Tapper WJ, Maniatis N, Morton NE, Collins A. (2003). A metric linkage disequilibrium map of a human chromosome. Ann Hum Genet. 67(Pt 6):487-94.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">The International HapMap Consortium. (2003). The International HapMap Project. Nature. 426(6968):789-96.&nbsp; </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">The International HapMap Consortium. (2005). A haplotype map of the human genome, Nature 437, 1299-1320.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">The International SNPWorking Group. (2001). A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409, 928&ndash;933.</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Wheeler D.L., Church D.M., Edgar R., Federhen S., Helmberg W., Madden T.L., Pontius J.U., Schuler G.D., Schriml L.M., Sequeira E, Suzek T.O., Tatusova T.A. and Wagner L. (2004) Database resources of the national center for biotechnology information: update. Nucleic Acids Res., 32, D35-D40. </span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움"><br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Zhang K, Sun F, Waterman MS, Chen T. (2003). Haplotype block partition with limited resources and applications to human chromosome 21 haplotype data. Am J Hum Genet. 73(1):63-73.&nbsp;<br /></span></p</ins>></div></td></tr>
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211.211.234.4
http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9068&oldid=prev
211.211.234.4 at 23:20, 13 April 2006
2006-04-13T23:20:35Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:20, 13 April 2006</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l52" >Line 52:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><p>&nbsp;</p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><p>&nbsp;</p></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p><br /><strong>엔코드 영역</strong><br /><!--StartFragment--></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p><br /><strong>엔코드 영역</strong><br /><!--StartFragment--></p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">bSNP에 등록된 모든 SNP와 추가적으로 resequencing을 통해 새로 발굴한 모든 SNP에 대해 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">보다 조밀한 간격으로 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">genotyping 실험을 진행하였다. 이 연구에서는 10개의 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Hapmap ENCODE 중에서 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">ENm010 영역을 분석에 사용하였다. </span></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">bSNP에 등록된 모든 SNP와 추가적으로 resequencing을 통해 새로 발굴한 모든 SNP에 대해 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">보다 조밀한 간격으로 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">genotyping 실험을 진행하였다. 이 연구에서는 10개의 </span><span style="FONT-SIZE: 11.5pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Hapmap ENCODE 중에서 </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">ENm010 영역을 분석에 사용하였다. </span></p></div></td></tr>
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211.211.234.4
http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9067&oldid=prev
211.211.234.4 at 23:20, 13 April 2006
2006-04-13T23:20:04Z
<p></p>
<a href="http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9067&oldid=9066">Show changes</a>
211.211.234.4
http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9066&oldid=prev
211.211.234.4 at 23:17, 13 April 2006
2006-04-13T23:17:05Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:17, 13 April 2006</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l46" >Line 46:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br /><strong>기대효과</strong><br /><!--StartFragment--></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><br /><strong>기대효과</strong><br /><!--StartFragment--></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임</span></p></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임<ins class="diffchange diffchange-inline"><br /><br /><!--StartFragment-->&nbsp;<!--StartFragment--></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">&gt;&gt;&nbsp;주요 제공 기능</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- Haploview: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype reconstruction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">LD Block partition, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Tagging SNP prediction, </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Disease Association</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- PHASE: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Recombination rate calculation</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">- TCS: </span><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">Haplotype Maximum Parsimony Tree construction<br /></span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div></span></p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></span></div></td></tr>
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211.211.234.4
http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9065&oldid=prev
211.211.234.4 at 23:13, 13 April 2006
2006-04-13T23:13:06Z
<p></p>
<table class="diff diff-contentalign-left" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 23:13, 13 April 2006</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><!--StartFragment-->&nbsp;<span style="FONT-SIZE: 12pt; LINE-HEIGHT: 130%; FONT-FAMILY: 휴먼명조,한컴돋움">한국인 HapMap 데이터베이스 개발<br /><br />목표:&nbsp;<!--StartFragment--> <span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">한국인 HapMap 과제에서 생산된 SNP 및 Haplotype 데이터를 D/B로 구축하고 LD 분석방법을 개발하며, 통합적인 HapMap 데이터마이닝 시스템을 구축함</span><br /><br />연구내용:&nbsp;<!--StartFragment--></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><!--StartFragment--<ins class="diffchange diffchange-inline">><strong</ins>>&nbsp;<ins class="diffchange diffchange-inline"></strong></ins><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 130%; FONT-FAMILY: 휴먼명조,한컴돋움"<ins class="diffchange diffchange-inline">><strong</ins>>한국인 HapMap 데이터베이스 개발<ins class="diffchange diffchange-inline"></strong></ins><br /><br /<ins class="diffchange diffchange-inline">><strong</ins>>목표<ins class="diffchange diffchange-inline"></strong></ins>:&nbsp;<!--StartFragment--> <span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">한국인 HapMap 과제에서 생산된 SNP 및 Haplotype 데이터를 D/B로 구축하고 LD 분석방법을 개발하며, 통합적인 HapMap 데이터마이닝 시스템을 구축함</span><br /><br /<ins class="diffchange diffchange-inline">><strong</ins>>연구내용:<ins class="diffchange diffchange-inline"></strong></ins>&nbsp;<!--StartFragment--></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ </span>국내 SNP 및 Haplotype 데이터의 D/B 구축</span></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ </span>국내 SNP 및 Haplotype 데이터의 D/B 구축</span></p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><ul></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><ul></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l45" >Line 45:</td>
<td colspan="2" class="diff-lineno">Line 45:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     </li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     </li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><br /></span></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><br /><ins class="diffchange diffchange-inline"><strong>기대효과</strong><br /><!--StartFragment--></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"><p class="HStyle0"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">과제를 통해 구축된 한국인 HapMap 데이터베이스와 검색시스템은 국내 연구자들이 질병연관 연구를 수행할 때 데이터마이닝 시스템으로 활용되어 암, 당뇨병 등과 같은 복합질병의 유전자를 찾는데 중요한 정보를 제공하게 될 것이며, 궁극적으로는 개인별 맞춤약물개발과 같은 신약개발의 중요한 자료로 이용될 수 있을 것임</span></p></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div></span></div></td></tr>
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211.211.234.4
http://Opengenome.net/index.php?title=%ED%95%9C%EA%B5%AD%EC%9D%B8_%ED%96%85%EB%A7%B5%EA%B3%BC%EC%A0%9C&diff=9064&oldid=prev
211.211.234.4 at 23:12, 13 April 2006
2006-04-13T23:12:12Z
<p></p>
<p><b>New page</b></p><div><!--StartFragment-->&nbsp;<span style="FONT-SIZE: 12pt; LINE-HEIGHT: 130%; FONT-FAMILY: 휴먼명조,한컴돋움">한국인 HapMap 데이터베이스 개발<br /><br />목표:&nbsp;<!--StartFragment--> <span style="FONT-SIZE: 12pt; LINE-HEIGHT: 160%; FONT-FAMILY: 휴먼명조,한컴돋움">한국인 HapMap 과제에서 생산된 SNP 및 Haplotype 데이터를 D/B로 구축하고 LD 분석방법을 개발하며, 통합적인 HapMap 데이터마이닝 시스템을 구축함</span><br /><br />연구내용:&nbsp;<!--StartFragment--><br />
<p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ </span>국내 SNP 및 Haplotype 데이터의 D/B 구축</span></p><br />
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<li><br />
<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;국내 SNP 및 Haplotype 데이터의 수집 기능 강화</span></div><br />
</li><br />
<li><br />
<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;구축 된 D/B의 검색 기능 개선</span></div><br />
</li><br />
</ul><br />
<p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ LD 및 기타 분석 프로그램 개발</span></p><br />
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<li><br />
<div><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;</span><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움; LETTER-SPACING: 0.4pt">LD block을 이용한 Population comparison system 개발</span></div><br />
</li><br />
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<div><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;자동화된 SNP 및 haplotype 분석 프로그램 개발</span></div><br />
</li><br />
</ul><br />
<p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ </span><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">각종 유전자정보와 연계된 HapMap 검색 시스템 구축</span></p><br />
<ul><br />
<li><br />
<div><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;유전자 별 HapMap 검색 시스템 구축</span></div><br />
</li><br />
<li><br />
<div><span style="FONT-SIZE: 10.8pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;ENCODE 부위별 HapMap 검색 시스템 구축</span></div><br />
</li><br />
</ul><br />
<p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ 통합적인 포탈 시스템 구축</span></p><br />
<ul><br />
<li><br />
<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;dbSNP 및 International HapMap 데이터의 포탈 기능 구축</span></div><br />
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<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;자동화된 통합적인 데이터의 포탈 기능 구축&nbsp; </span></div><br />
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<p class="HStyle0" style="MARGIN-TOP: 4pt; MARGIN-LEFT: 5pt; LINE-HEIGHT: 140%"><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">○ 통합적인 HapMap 데이터마이닝 시스템 구축</span></p><br />
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<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;인종 간 HapMap 비교 검색 시스템 구축</span></div><br />
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<div><span style="FONT-SIZE: 12pt; LINE-HEIGHT: 140%; FONT-FAMILY: 휴먼명조,한컴돋움">&nbsp;&nbsp;유전자 및 부위별 HapMap 검색 시스템의 기능 강화</span></div><br />
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