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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_DNAfragmentPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_DNAfragmentPathway.gif</a><br /><br />Apoptotic cell death는&nbsp;많은 different cellular stimuli에 의해서 반응이 일어날 수 있는데, 결과적으로 apoptotic signaling pathway는 caspases(See Caspase Cascade pathway)와 mitochondria(See Role of Mitochondria in Apoptotic Signaling pathway)를 포함하는 것의 활성으로 나타난다.&nbsp; 세포를 알아보는 방법으로 apoptosis의 characteristic은 nucleosomal ladder를 생성하는 nuclear genome의 단편으로부터 알아볼 수 있다. 이러한 활성은 apoptotic signaling pathways에 의한 multiple nucleases에 의해서 인도되어진다.<br />Pathway Interaction<br /> <table style="WIDTH: 788px; HEIGHT: 579px" cellspacing="1" cellpadding="1" width="788" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">BAX</p> </td> <td> <p align="center">BID</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">BCL-2</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">BCL-XL</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">BAD</p> </td> <td> <p align="center">AKT pathway</p> </td> </tr> <tr> <td> <p align="center">AKT</p> </td> <td> <p align="center">BAD</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Pro-CASPASE</p> </td> </tr> <tr> <td> <p align="center">APAF-1</p> </td> <td> <p align="center">Cytochrome C</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">pro-caspase 9</p> </td> </tr> <tr> <td> <p align="center">BCL2</p> </td> <td> <p align="center">BCL-KL</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">BAX</p> </td> </tr> <tr> <td> <p align="center">TLN</p> </td> <td> <p align="center">PAXILLIN</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PKC</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">EIF2a</p> </td> </tr> <tr> <td> <p align="center">EIF2a</p> </td> <td> <p align="center">STAT1</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Capases</p> </td> </tr> <tr> <td> <p align="center">ATM</p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">CASP3</p> </td> <td> <p align="center">pro-caspase3</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">caspase6</p> </td> </tr> <tr> <td> <p align="center">CASP7</p> </td> <td> <p align="center">FAK, PKC 등의 Modified signaling</p> </td> </tr> <tr> <td> <p align="center">CYCS</p> </td> <td> <p align="center">ADAF-1</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Pro-caspase 9</p> </td> </tr> <tr> <td> <p align="center">STAT1</p> </td> <td> <p align="center">PAXILLIN</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">EIF2a</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PARP</p> </td> </tr> <tr> <td> <p align="center">PARP</p> </td> <td> <p align="center">CASPASES</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">STAT1</p> </td> </tr> </tbody> </table>

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