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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_pkcPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_pkcPathway.gif</a><br /><br />Plasma membrane을 가로지르는 extracellular envuronment로부터 signals의 다양함을 transduction한다.<br />일반적 signaling systems의 하나는 PKC(Protein Kinase C)를 활성화시키는 GPCRs에 의해서 이용된다.<br />Serine/Threonine protein kinases의 ubiquitous family들의 pathway는 receptor가 ligand를 거슬러서 붙잡았을 때 Gq G-proteins를 활성화하면서 상호작용하는 GPCRs의 class와 함께 시작되는 PKC 활성을 가지고 온다.<br /><br />Pathway Interaction<br /> <table style="WIDTH: 578px; HEIGHT: 123px" cellspacing="1" cellpadding="1" width="578" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">NFkB</p> </td> <td> <p align="center">IkB</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">NFkB pathway</p> </td> </tr> <tr> <td> <p align="center">PLC</p> </td> <td> <p align="center">G9</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PIP2</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">DAG</p> </td> </tr> </tbody> </table>

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