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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_relaPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_relaPathway.gif</a><br /><br />Transcription factor의 rel/NF-kB family는 immune response, hematopoeisis, inflammation에&nbsp; 포함되는 gene의 활성을 조절한다.<br />NF-kB는 단백질의 종류인 p65(rel), p50과 함께 복합체를 구성하고 있고, I-kB에 의해서 cytoplasm에서 활성을 잃게 된다.<br />TNF 또는 일반적 다른 factors에 의해서 신호가 시작되기 전에 I-kB의 phosphorylation과 degradation이 일어나게 된다.<br />DNA에 붙어 있는 NF-kB의 subsequent가 떨어지면 다시 gene이 활성을 가지게 된다.<br />(see pathways for TNRR1, TNFR2, NF-kB, Toll-like receptors, ATM,etc)<br />NF-kB에 의한 transcription의 활성은 p300과 같은 transcriptional [[coactivators]]가 필요하다.<br />CBP는 transcriptional apparatus(기관)의 나머지와 상호작용을 하는데, 이러한 coactivators는 효소를 활성화 시킨다.<br /><br />Pathway interaction<br /> <table style="WIDTH: 448px; HEIGHT: 256px" cellspacing="1" cellpadding="1" width="448" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center"><br />FADD</p> </td> <td> <p align="center">TNFR</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">TRADD</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">RIP</p> </td> </tr> <tr> <td> <p align="center">TRAF6</p> </td> <td> <p align="center">TRADD</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">RIP</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">NFkB Pathway</p> </td> </tr> <tr> <td> <p align="center">RELA</p> </td> <td> <p align="center">IkBa</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">p50</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">p300</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">CBP</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">HDAC3</p> </td> </tr> </tbody> </table> <br />

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