View source for AKT signaling pathway

<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_aktPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_aktPathway.gif</a><br /><br />많은 cell-surface receptors는 PIP3(Phosphatidylinositol 3,4,5-triphosphate)같은 두번째 messengers의 생성을 포함하는데, 이것은 cell surface로부터 cytoplasm으로 신호를 전달하는 역할을 한다.&nbsp; PIP3 signals는 kinase PDK1(3-phosphoinositide-dipendent protein kinase-1)을 활성화시키고, 이것은 kinase AKT를 다시 활성화시키는데, 또한 이것은 protein kinase B로도 아려져 있다. AKT를 활성화시킴으로써 단백질은 인산화되어지고, cell이 살아남는 것을 촉진시킨다.<br />Pathway Interaction<br />
<table style="WIDTH: 633px; HEIGHT: 243px" cellspacing="1" cellpadding="1" width="633" summary="" border="1">
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            <td>&nbsp;</td>
            <td>&nbsp;</td>
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            <td>
            <p align="center">AKT</p>
            </td>
            <td>
            <p align="center">hsp90</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">mTOR pathway</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">PDK1</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">PP2A</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">Caspase9</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">FKHRL1</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">BAD</p>
            </td>
            <td>
            <p align="center">Cell survival</p>
            </td>
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        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">Apoptosis</p>
            </td>
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        <tr>
            <td>
            <p align="center">PI3K</p>
            </td>
            <td>
            <p align="center">GHR</p>
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        </tr>
        <tr>
            <td>
            <p align="center">&nbsp;</p>
            </td>
            <td>
            <p align="center">PIP2</p>
            </td>
        </tr>
        <tr>
            <td>
            <p align="center">NFkB</p>
            </td>
            <td>
            <p align="center">IkBa</p>
            </td>
        </tr>
    </tbody>
</table>