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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_akap95Pathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_akap95Pathway.gif</a><br /><br />AKAP95(A-kinase anchoring protein)은 cell cycle의 다른 기간동안 다른 단백질과 DNA를 붙잡는 단백질을 결합시키는 nuclear matrix 이다.<br />DNA와 단백질과 함께 AKAP95의 상호작용은 chromatin의 [[transcription]]과 [[condensation]]을 억제하는 역할을 한다. AKAP95의 특별한 domain은 nuclear matrix와 DNA와 함께 연관되어지는 다른 조절자와 함께 상호작용을 함으로써 조절되어진다.&nbsp; 주요 단백질인 AKAP95와의 상호작용은 cAMP-dependent protein kinase인 PKA로 이루어진다.<br /><br />Pathway Interaction<br /> <table style="WIDTH: 623px; HEIGHT: 247px" cellspacing="1" cellpadding="1" width="623" summary="" border="1"> <tbody> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> <tr> <td> <p align="center">AKA95</p> </td> <td> <p align="center">p68</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">DNA</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">RⅡa</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">RⅡb</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">PKAC</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">Eg7</p> </td> </tr> <tr> <td> <p align="center">PPA</p> </td> <td> <p align="center">PKAc</p> </td> </tr> <tr> <td> <p align="center">PKA</p> </td> <td> <p align="center">RⅡa</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">RⅡb</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">CDK1</p> </td> </tr> <tr> <td> <p align="center">&nbsp;</p> </td> <td> <p align="center">AKap95</p> </td> </tr> </tbody> </table>

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