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<h2><span id="Signs_and_symptoms" class="mw-headline">Signs and symptoms</span></h2>
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<div style="WIDTH: 182px" class="thumbinner"><a class="image" href="/wiki/File:Linitis_plastica_2.jpg"><img class="thumbimage" alt="" width="180" height="165" src="http://upload.wikimedia.org/wikipedia/commons/thumb/9/94/Linitis_plastica_2.jpg/180px-Linitis_plastica_2.jpg" width="180" height="165" /></a>
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Endoscopic image of <a title="Linitis plastica" href="/wiki/Linitis_plastica"><font color="#002bb8">linitis plastica</font></a>, a type of stomach cancer where the entire <a title="Stomach" href="/wiki/Stomach"><font color="#002bb8">stomach</font></a> is invaded, leading to a leather bottle-like appearance with <a title="Bleeding" href="/wiki/Bleeding"><font color="#002bb8">blood</font></a> coming out of it.</div>
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<h3><span id="Histopathology" class="mw-headline">Histopathology</span></h3>
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<div style="WIDTH: 182px" class="thumbinner"><a class="image" href="/wiki/File:Adenocarcinoma_low_differentiated_(stomach)_H%26E_magn_400x.jpg"><img class="thumbimage" alt="" width="180" height="144" src="http://upload.wikimedia.org/wikipedia/commons/thumb/8/85/Adenocarcinoma_low_differentiated_%28stomach%29_H%26E_magn_400x.jpg/180px-Adenocarcinoma_low_differentiated_%28stomach%29_H%26E_magn_400x.jpg" width="180" height="144" /></a>
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Poor to moderately differentiated adenocarcinoma of the stomach. <a title="H&E stain" href="/wiki/H%26E_stain"><font color="#002bb8">H&E stain</font></a>.</div>
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<div style="WIDTH: 182px" class="thumbinner"><a class="image" href="/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg"><img class="thumbimage" alt="" width="180" height="135" src="http://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Gastric_signet_ring_cell_carcinoma_histopatholgy_%281%29.jpg/180px-Gastric_signet_ring_cell_carcinoma_histopatholgy_%281%29.jpg" width="180" height="135" /></a>
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Gastric signet ring cell carcinoma. <a title="H&E stain" href="/wiki/H%26E_stain"><font color="#002bb8">H&E stain</font></a>.</div>
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<div style="WIDTH: 182px" class="thumbinner"><a class="image" href="/wiki/File:Gastric_adenocarcinoma.jpg"><img class="thumbimage" alt="" width="180" height="135" src="http://upload.wikimedia.org/wikipedia/commons/thumb/5/56/Gastric_adenocarcinoma.jpg/180px-Gastric_adenocarcinoma.jpg" width="180" height="135" /></a>
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Adenocarcinoma of the stomach and <a title="Intestinal metaplasia" href="/wiki/Intestinal_metaplasia"><font color="#002bb8">intestinal metaplasia</font></a>. <a title="H&E stain" href="/wiki/H%26E_stain"><font color="#002bb8">H&E stain</font></a>.</div>
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<h2><span id="Epidemiology" class="mw-headline">Epidemiology</span></h2>
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<div style="WIDTH: 182px" class="thumbinner"><a class="image" href="/wiki/File:Stomach_cancer_world_map_-_Death_-_WHO2004.svg"><img class="thumbimage" alt="" width="180" height="79" src="http://upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Stomach_cancer_world_map_-_Death_-_WHO2004.svg/180px-Stomach_cancer_world_map_-_Death_-_WHO2004.svg.png" width="180" height="79" /></a>
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<a title="Age adjustment" href="/wiki/Age_adjustment"><font color="#002bb8">Age-standardized</font></a> death from stomach cancer per 100,000 inhabitants in 2004.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><font size="1"><font color="#002bb8"><span>[</span>14<span>]</span></font></font></a></sup>
<div style="-moz-column-count: 3; column-count: 3" class="references-small"><span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #b3b3b3 1px solid; BORDER-LEFT: #b3b3b3 1px solid; BACKGROUND-COLOR: #b3b3b3; COLOR: #b3b3b3; BORDER-TOP: #b3b3b3 1px solid; BORDER-RIGHT: #b3b3b3 1px solid"> </span> no data</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ffff65 1px solid; BORDER-LEFT: #ffff65 1px solid; BACKGROUND-COLOR: #ffff65; COLOR: #ffff65; BORDER-TOP: #ffff65 1px solid; BORDER-RIGHT: #ffff65 1px solid"> </span> less than 3.5</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #fff200 1px solid; BORDER-LEFT: #fff200 1px solid; BACKGROUND-COLOR: #fff200; COLOR: #fff200; BORDER-TOP: #fff200 1px solid; BORDER-RIGHT: #fff200 1px solid"> </span> 3.5-8</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ffdc00 1px solid; BORDER-LEFT: #ffdc00 1px solid; BACKGROUND-COLOR: #ffdc00; COLOR: #ffdc00; BORDER-TOP: #ffdc00 1px solid; BORDER-RIGHT: #ffdc00 1px solid"> </span> 8-12.5</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ffc600 1px solid; BORDER-LEFT: #ffc600 1px solid; BACKGROUND-COLOR: #ffc600; COLOR: #ffc600; BORDER-TOP: #ffc600 1px solid; BORDER-RIGHT: #ffc600 1px solid"> </span> 12.5-17</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ffb000 1px solid; BORDER-LEFT: #ffb000 1px solid; BACKGROUND-COLOR: #ffb000; COLOR: #ffb000; BORDER-TOP: #ffb000 1px solid; BORDER-RIGHT: #ffb000 1px solid"> </span> 17-21.5</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff9a00 1px solid; BORDER-LEFT: #ff9a00 1px solid; BACKGROUND-COLOR: #ff9a00; COLOR: #ff9a00; BORDER-TOP: #ff9a00 1px solid; BORDER-RIGHT: #ff9a00 1px solid"> </span> 21.5-26</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff8400 1px solid; BORDER-LEFT: #ff8400 1px solid; BACKGROUND-COLOR: #ff8400; COLOR: #ff8400; BORDER-TOP: #ff8400 1px solid; BORDER-RIGHT: #ff8400 1px solid"> </span> 26-30.5</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff6e00 1px solid; BORDER-LEFT: #ff6e00 1px solid; BACKGROUND-COLOR: #ff6e00; COLOR: #ff6e00; BORDER-TOP: #ff6e00 1px solid; BORDER-RIGHT: #ff6e00 1px solid"> </span> 30.5-35</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff5800 1px solid; BORDER-LEFT: #ff5800 1px solid; BACKGROUND-COLOR: #ff5800; COLOR: #ff5800; BORDER-TOP: #ff5800 1px solid; BORDER-RIGHT: #ff5800 1px solid"> </span> 35-40</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff4200 1px solid; BORDER-LEFT: #ff4200 1px solid; BACKGROUND-COLOR: #ff4200; COLOR: #ff4200; BORDER-TOP: #ff4200 1px solid; BORDER-RIGHT: #ff4200 1px solid"> </span> 40-45</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #ff2c00 1px solid; BORDER-LEFT: #ff2c00 1px solid; BACKGROUND-COLOR: #ff2c00; COLOR: #ff2c00; BORDER-TOP: #ff2c00 1px solid; BORDER-RIGHT: #ff2c00 1px solid"> </span> 45-50</span> <span style="PADDING-BOTTOM: 1px; MARGIN: 0px; DISPLAY: block; FONT-SIZE: 90%"><span style="BORDER-BOTTOM: #cb0000 1px solid; BORDER-LEFT: #cb0000 1px solid; BACKGROUND-COLOR: #cb0000; COLOR: #cb0000; BORDER-TOP: #cb0000 1px solid; BORDER-RIGHT: #cb0000 1px solid"> </span> more than 50</span></div>
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<h2><span id="External_links" class="mw-headline">External links</span></h2>
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<li><a title="National Cancer Institute" href="/wiki/National_Cancer_Institute"><font color="#002bb8">National Cancer Institute</font></a> <a class="external text" rel="nofollow" href="http://www.cancer.gov/cancertopics/pdq/treatment/gastric/HealthProfessional/page1" rel="nofollow"><font color="#3366bb">Gastric cancer treatment guidelines</font></a> </li> <li><a class="external text" rel="nofollow" href="http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hgc" rel="nofollow"><font color="#3366bb">GeneReview/NIH/UW entry on Hereditary Diffuse Gastric Cancer</font></a> </li> <li><a class="external text" rel="nofollow" href="http://www.nostomachforcancer.org" rel="nofollow"><font color="#3366bb">No Stomach For Cancer | Be Strong Hearted</font></a> is a source of information and support for Hereditary Diffuse Gastric Cancer and carriers of the CDH1 gene mutation and their families/friends. </li> <li><span class="citation web"><a class="external text" rel="nofollow" href="http://web.tiscali.it/iodio/" rel="nofollow"><font color="#3366bb">"Stomach Cancer. In: Iodine Deficiency: studies by dr. Sebastiano Venturi (Italy)"</font></a><span class="printonly">. <a class="external free" rel="nofollow" href="http://web.tiscali.it/iodio/" rel="nofollow"><font color="#3366bb">http://web.tiscali.it/iodio/</font></a></span><span class="reference-accessdate">. Retrieved 2008-05-15</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Stomach+Cancer.+In%3A+Iodine+Deficiency%3A+studies+by+dr.+Sebastiano+Venturi+%28Italy%29&rft.atitle=&rft_id=http%3A%2F%2Fweb.tiscali.it%2Fiodio%2F&rfr_id=info:sid/en.wikipedia.org:Stomach_cancer"><span style="DISPLAY: none"> </span></span> </li>
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