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DHEA
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<p><span class="mw-headline"><font size="5"><br />Synonyms and brand names</font></span></p>
<p>Synonyms for Dehydroepiandrosterone are: Dehydroisoandrosterone; 3β-Hydroxy-5-androsten-17-one; 3β-Hydroxyandrost-5-en-17-one; Androstenol; Androstenolone; Dehydroisoandrosterone; Hydroxyandrost-5-en-17-one; Prasterone; trans-Dehydroandrosterone.</p>
<p>Brand names for DHEA include Prastera® and Fidelin®.</p>
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<p><span class="mw-headline"><font size="5"><br />DHEAS (Dehydroepiandrosterone sulfate)</font></span></p>
<p><strong>Dehydroepiandrosterone sulfate</strong> (<strong>DHEAS</strong>, PubChem 12594) is the sulfated version of DHEA, - this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEAS with levels that are about 300 times higher than free DHEA. Orally ingested DHEA is converted to its sulfate when passing through intestines and liver. While DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation.</p>
<p>From a practical point measurement of DHEAS is preferable to DHEA as levels are more stable.</p>
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<p><span class="mw-headline"><font size="5"><br />Production</font></span></p>
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<div class="thumbinner" style="WIDTH: 302px"><img class="thumbimage" height="121" alt="Production of DHEA from Cholesterol" width="300" longdesc="/wiki/Image:DHEA1.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/6/6c/DHEA1.svg/300px-DHEA1.svg.png" />
<p>As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS.</p>
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<p><span class="mw-headline"><font size="5"><br />Effects</font></span></p>
<p>Studies have shown that DHEA is useful in patients with systemic lupus erythematosus. An application of the evidence was reviewed by the FDA in 2001 and is available online.<sup class="reference" id="_ref-0">[1]</sup> This review also shows that cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).</p>
<p>Supplementation with DHEA has been shown to decrease insulin resistance.<sup class="reference" id="_ref-1">[2]</sup></p>
