<p><strong>Protein-protein interaction prediction</strong> is a field combining bioinformatics and structural biology in an attempt to identify and catalog interactions between pairs or groups of proteins. Understanding <font color="#810081">protein-protein interactions</font> is important in investigating intracellular signaling pathways. Experimentally, interactions between pairs of proteins are inferred from yeast two-hybrid systems, from affinity purification/mass spectrometry assays, or from protein microarrays. In parallel to the experimental determination of the interactome, computational methods are being developed.</p>

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<h2><span class="mw-headline">Methods</span></h2>