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<p class="MsoTitle" style="MARGIN: 12pt 0cm 6pt"><span style="FONT-SIZE: 11pt; FONT-FAMILY: 바탕; LETTER-SPACING: -0.6pt"><font face="Tahoma" size="5"><strong>&nbsp; </strong></font></span><span lang="EN-US" style="FONT-SIZE: 11pt; FONT-FAMILY: 바탕"><font face="Tahoma" size="5"><strong>(</strong></font></span><span lang="EN" style="FONT-SIZE: 11pt; FONT-FAMILY: 바탕; mso-ansi-language: EN"><a title="Avian flu" href="http://en.wikipedia.org/wiki/Avian_flu"><span style="COLOR: black; TEXT-DECORATION: none; text-underline: none"><font face="Tahoma" size="5"><strong>Avian Avian_ Influenza</strong></font></span></a><font face="Tahoma" size="5"><strong>)</strong></font><span style="LETTER-SPACING: -0.6pt"><strong>&nbsp;<br />

<p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l0 level1 lfo2; tab-stops: list 62.35pt left 81.0pt"><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-bidi-font-size: 10.0pt"><span style="mso-list: Ignore"><font size="2">⑤</font><span style="FONT: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: Tahoma; mso-bidi-font-size: 10.0pt"><font size="2">AI virus의 경우 막에 표면에 있는 haemagglutinin(HA), neuraminidase (NA) 단백질 조합에 의해 종류가 결정되며 이 중 avian influenza A 고병원성 H5N1 type이 인체감염을 일으키는 실례들이 보고되어 있음<br /></font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l0 level1 lfo2; tab-stops: list 62.35pt"><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-bidi-font-size: 10.0pt"><span style="mso-list: Ignore"><font size="2">⑥</font><span style="FONT: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: Tahoma; mso-bidi-font-size: 10.0pt"><font size="2">H5N1 avian influenza neuraminidase inhibitor가 치료제로 사용되고 있음.<br /></font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l0 level1 lfo2; tab-stops: list 62.35pt"><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-bidi-font-size: 10.0pt"><span style="mso-list: Ignore"><font size="2">⑦</font><span style="FONT: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: Tahoma; mso-bidi-font-size: 10.0pt"><font size="2">미국<span lang="EN-US"> NCBI의 경우 Influenza Virus Sequence Database를 서비스 중<span style="mso-spacerun: yes">&nbsp; </span>(http://www.ncbi.nlm.nih.gov/genomes/FLU/FLU.html)<br /></span></font></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l0 level1 lfo2; tab-stops: list 62.35pt"><span lang="EN-US" style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: 굴림; mso-bidi-font-size: 10.0pt"><span style="mso-list: Ignore"><font size="2">⑧</font><span style="FONT: 7pt &quot;Times New Roman&quot;">&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span><span style="COLOR: black; FONT-FAMILY: 굴림; mso-bidi-font-family: Tahoma; mso-bidi-font-size: 10.0pt"><font size="2">조류독감 바이러스<span lang="EN-US"> haemagglutinin (HA) 단백질의 아미노산 변이가 생긴 경우 인간형 수용체(human-type receptor) 와 결합하게 되는 예가 보고됨 (Nature, 2006 )<br />

<p class="headline">ABI to Debut Avian Assays in Europe This Summer; Firm Chatting With FDA</p><p class="bodycopy">[March 7, 2007]</p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l1 level1 lfo1; tab-stops: list 45.0pt 63.0pt">&nbsp;</p><p>By <a href="http://www.genomeweb.com/cgi-bin/udt/im.author.contact.view?client_id=genomewebnews&amp;story_id=138811&amp;title=ABI%20to%20Debut%20Avian%20Assays%20in%20Europe%20This%20Summer%3B%20Firm%20Chatting%20With%20FDA&amp;author=Matt%20Jones&amp;address=http%3A//www.genomeweb.com/issues/news/138811%2D1.html&amp;summary=UPDATE">Matt Jones</a> <br /><em>a GenomeWeb News reporter</em> </p><p>&nbsp;</p><div><span class="bodycopy"><div><em>This update includes comments from an ABI spokesperson.</em></div><div>&nbsp;</div><div>NEW YORK (GenomeWeb News) &mdash; Applied Biosystems plans to make and market pathogen-detecting assay kits through a collaboration with the UK government&rsquo;s Veterinary Laboratories Agency, the company said today. </div><div>&nbsp;</div><div>Under the agreement, ABI will build one test kit for avian influenza and one for Newcastle disease, ABI said. Both kits, which the company said are designed to help doctors detect bird-borne diseases, will be marketed widely in Europe, Asia and Africa, but will not be available in the US. &nbsp;</div><div>&nbsp;</div><div>VLA will validate the assays, ABI said. </div><div>&nbsp;</div><div>ABI said the VLA used the kits to confirm that the 2,600 turkeys that recently died in Suffolk, England, were killed by the H5N1 strain of avian_flu, and were subsequently used in a follow-up survey of the region&rsquo;s population of wild birds. </div><div>&nbsp;</div><div>Early detection allowed for a swift containment response in this case, the company said, adding that&nbsp;the goal of the collaboration is to make the assays available for &ldquo;the same type of early warning detection in various countries. </div><div>&nbsp;</div><div>Financial terms of the agreement were not released. </div><div>&nbsp;</div><div>ABI Europe spokesman Tony Hardware said the company expects the tests to be available in the late summer.</div><div>&nbsp;</div><div>Hardware said the company expects to receive European CE Mark certification for the kits &ldquo;rather quickly,&rdquo; and should be deploying in Europe sometime around August. The assays will be available in Africa and Asia sometime after that.</div><div>&nbsp;</div><div>ABI is &ldquo;involved in discussions&rdquo; with US officials about seeking FDA approval to market the products in the US, Hardware said, but he could not estimate a timetable for a US deployment. </div></span></div><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 63pt; TEXT-INDENT: -18pt; mso-list: l1 level1 lfo1; tab-stops: list 45.0pt 63.0pt"><br /><br /></p>