Changes

Evolution

258,969 bytes added, 09:04, 5 May 2007

no edit summary

정의 [http://evolomics.org Evolomics.org] | [http://evolome.org Evolome.org]Biological evolution is the change in a population's inherited traits from generation to generation. These traits are encoded as genes that are copied and passed on to offspring during reproduction. Mutations and other random changes in these genes can produce new or altered traits, resulting in inheritable differences (genetic variation) between organisms. Evolution occurs when these differences become more common or rare in a population. This either happens through natural selection, which is caused by differences in the reproductive value of the traits, or randomly through genetic drift.Natural selection occurs because organisms with traits that help them survive and reproduce tend to have more offspring. In doing so, they will pass more copies of their inheritable traits on to the next generation. This process causes advantageous traits to become more common over time, while disadvantageous ones become rarer.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Futuyma">[1]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-0">[2]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-1">[3]</a> Over many generations, this process can produce varied <a title="Adaptation" href="http://en.wikipedia.org/wiki/Adaptation">adaptations</a> to environmental conditions.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-understandingevolution">[4]</a> As genetic differences in and between populations of a species accumulate, this <a title="Species" href="http://en.wikipedia.org/wiki/Species">species</a> may split into <a title="Speciation" href="http://en.wikipedia.org/wiki/Speciation">new species</a>. The similarities between organisms suggest that all known species are <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">descended from a single ancestral species</a> through this process of gradual divergence.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Futuyma">[1]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-2">[5]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-3">[6]</a>The <a title="Theory" href="http://en.wikipedia.org/wiki/Theory">theory</a> of evolution by natural selection was first put forth in detail in <a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Charles Darwin</a>'s 1859 book <a title="The Origin of Species" href="http://en.wikipedia.org/wiki/The_Origin_of_Species">On the Origin of Species</a>. In the 1930s, Darwinian natural selection was combined with <a title="Gregor Mendel" href="http://en.wikipedia.org/wiki/Gregor_Mendel">Mendelian</a> <a title="Mendelian inheritance" href="http://en.wikipedia.org/wiki/Mendelian_inheritance">inheritance</a> to form the <a title="Modern evolutionary synthesis" href="http://en.wikipedia.org/wiki/Modern_evolutionary_synthesis">modern evolutionary synthesis</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-understandingevolution">[4]</a> With its enormous explanatory and <a title="Predictive power" href="http://en.wikipedia.org/wiki/Predictive_power">predictive power</a>, this theory has become the central organizing principle of modern biology, providing a unifying explanation for the <a title="Biodiversity" href="http://en.wikipedia.org/wiki/Biodiversity">diversity of life</a> on Earth.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-4">[7]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-5">[8]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-6">[9]</a> <h2>History of evolutionary thought</h2><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="History of evolutionary thought" href="http://en.wikipedia.org/wiki/History_of_evolutionary_thought">History of evolutionary thought</a>. </dd></dl></div><div class="thumb tleft"><div class="thumbinner" style="WIDTH: 152px"><a class="internal" title="Charles Darwin at age 51, just after publishing The Origin of Species." href="http://en.wikipedia.org/wiki/Image:Charles_Darwin_aged_51_crop.jpg"><img class="thumbimage" height="168" alt="Charles Darwin at age 51, just after publishing The Origin of Species." width="150" longdesc="/wiki/Image:Charles_Darwin_aged_51_crop.jpg" src="http://upload.wikimedia.org/wikipedia/en/thumb/5/58/Charles_Darwin_aged_51_crop.jpg/150px-Charles_Darwin_aged_51_crop.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Charles_Darwin_aged_51_crop.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div><a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Charles Darwin</a> at age 51, just after publishing <a title="The Origin of Species" href="http://en.wikipedia.org/wiki/The_Origin_of_Species">The Origin of Species</a>.</div></div></div><div class="thumb tright"><div class="thumbinner" style="WIDTH: 155px"><a class="internal" title="Gregor Mendel's work on the inheritance of traits in pea plants laid the foundation for genetics." href="http://en.wikipedia.org/wiki/Image:Mendel.png"><img class="thumbimage" height="204" alt="Gregor Mendel's work on the inheritance of traits in pea plants laid the foundation for genetics." width="153" longdesc="/wiki/Image:Mendel.png" src="http://upload.wikimedia.org/wikipedia/commons/7/76/Mendel.png" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Mendel.png"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div><a title="Gregor Mendel" href="http://en.wikipedia.org/wiki/Gregor_Mendel">Gregor Mendel</a>'s work on the <a title="Mendelian inheritance" href="http://en.wikipedia.org/wiki/Mendelian_inheritance">inheritance</a> of traits in pea plants laid the foundation for <a title="Genetics" href="http://en.wikipedia.org/wiki/Genetics">genetics</a>.</div></div></div>Evolutionary ideas such as <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">common descent</a> and the <a title="Transmutation of species" href="http://en.wikipedia.org/wiki/Transmutation_of_species">transmutation of species</a> have existed since at least the 6th century BCE, when they were expounded by the Greek philosopher <a title="Anaximander" href="http://en.wikipedia.org/wiki/Anaximander">Anaximander</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Osborn">[10]</a> A variety of such ideas developed in the 18th century, and in 1809 <a title="Jean-Baptiste Lamarck" href="http://en.wikipedia.org/wiki/Jean-Baptiste_Lamarck">Lamarck</a> contended that <a title="Transmutation of species" href="http://en.wikipedia.org/wiki/Transmutation_of_species">transmutation of species</a> occurred as parents <a title="Inheritance of acquired characters" href="http://en.wikipedia.org/wiki/Inheritance_of_acquired_characters">passed on adaptations acquired</a> during their lifetimes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-7">[11]</a> These ideas were seen in England as a threat to political and religious stability and strongly opposed by the scientific establishment.In 1858 <a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Charles Darwin</a> and <a title="Alfred Russel Wallace" href="http://en.wikipedia.org/wiki/Alfred_Russel_Wallace">Alfred Russel Wallace</a> jointly presented the theory of evolution by natural selection to the <a title="Linnean Society of London" href="http://en.wikipedia.org/wiki/Linnean_Society_of_London">Linnean Society of London</a> in <a title="On the Tendency of Species to form Varieties; and on the Perpetuation of Varieties and Species by Natural Means of Selection" href="http://en.wikipedia.org/wiki/On_the_Tendency_of_Species_to_form_Varieties%3B_and_on_the_Perpetuation_of_Varieties_and_Species_by_Natural_Means_of_Selection">separate papers</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-8">[12]</a> This received little attention, but in 1859 the publication of Darwin's <a title="The Origin of Species" href="http://en.wikipedia.org/wiki/The_Origin_of_Species">The Origin of Species</a> provided detailed support for the theory and led to increasingly wide acceptance that evolution occurred. Darwin's specific ideas about evolution, such as <a title="Gradualism" href="http://en.wikipedia.org/wiki/Gradualism">gradualism</a> and natural selection, were strongly contested at first. <a title="Lamarckism" href="http://en.wikipedia.org/wiki/Lamarckism">Lamarckists</a> argued, for example, that <a title="Waterfowl" href="http://en.wikipedia.org/wiki/Waterfowl">waterfowl</a> acquired webbed feet through their efforts to swim, rather than through a selective process of birds with some skin between their toes out-competing birds with none.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Osborn">[10]</a> Eventually, when experiments failed to support it, this rival theory was abandoned in favor of Darwinism.However, Darwin could not explain how traits were passed down from generation to generation or why variations in traits were not blended together through inheritance. A mechanism was provided in 1865 by <a title="Gregor Mendel" href="http://en.wikipedia.org/wiki/Gregor_Mendel">Gregor Mendel</a>, whose research revealed that distinct traits were <a title="Mendelian inheritance" href="http://en.wikipedia.org/wiki/Mendelian_inheritance">inherited</a> in a well-defined and predictable manner.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Weiling">[13]</a> When Mendel's work was rediscovered in 1900, disagreements over the rate of evolution predicted by early geneticists and <a title="Biostatistics" href="http://en.wikipedia.org/wiki/Biostatistics">biometricians</a> led to a rift between the Mendelian and Darwinian models of evolution. However, this contradiction was reconciled in the 1930s through the work of biologists such as <a title="Ronald Fisher" href="http://en.wikipedia.org/wiki/Ronald_Fisher">Ronald Fisher</a>. The end result was a combination of Darwinian natural selection with Mendelian inheritance, the <a title="Modern evolutionary synthesis" href="http://en.wikipedia.org/wiki/Modern_evolutionary_synthesis">modern evolutionary synthesis</a>, or "Neo-Darwinism".<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-9">[14]</a> Finally, the identification of <a title="DNA" href="http://en.wikipedia.org/wiki/DNA">DNA</a> as the genetic material by <a title="Oswald Avery" href="http://en.wikipedia.org/wiki/Oswald_Avery">Oswald Avery</a> in 1944,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-10">[15]</a> and the subsequent publication of the structure of DNA by <a title="James D. Watson" href="http://en.wikipedia.org/wiki/James_D._Watson">James Watson</a> and <a title="Francis Crick" href="http://en.wikipedia.org/wiki/Francis_Crick">Francis Crick</a> in 1953,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Watson">[16]</a> demonstrated the physical basis for inheritance. Since then, <a title="Genetics" href="http://en.wikipedia.org/wiki/Genetics">genetics</a> and <a title="Molecular biology" href="http://en.wikipedia.org/wiki/Molecular_biology">molecular biology</a> have become central to <a title="Evolutionary biology" href="http://en.wikipedia.org/wiki/Evolutionary_biology">evolutionary biology</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-11">[17]</a> <h2>Heredity</h2><div class="thumb tright"><div class="thumbinner" style="WIDTH: 183px"><a class="internal" title="A section of a model of a DNA molecule. Also: animated version" href="http://en.wikipedia.org/wiki/Image:ADN_static.png"><img class="thumbimage" height="313" alt="A section of a model of a DNA molecule. Also: animated version" width="181" longdesc="/wiki/Image:ADN_static.png" src="http://upload.wikimedia.org/wikipedia/en/c/c2/ADN_static.png" /></a><div class="thumbcaption">A section of a model of a DNA molecule.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-12">[18]</a> Also: <a title="Image:ADN animation.gif" href="http://en.wikipedia.org/wiki/Image:ADN_animation.gif">animated version</a></div></div></div><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Introduction to genetics" href="http://en.wikipedia.org/wiki/Introduction_to_genetics">Introduction to genetics</a>, <a title="Genetics" href="http://en.wikipedia.org/wiki/Genetics">Genetics</a>, and <a title="Heredity" href="http://en.wikipedia.org/wiki/Heredity">Heredity</a>. </dd></dl></div>Gregor Mendel's work on pea plants provided the first firm demonstration that heredity occurred in discrete units.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Weiling">[13]</a> He was able to show that the traits were inherited from parent to offspring and that traits were discrete, since if one parent had round peas and the other wrinkled, the progeny were not intermediate, but either round or wrinkled. He also showed that the traits of the parents were distributed to progeny in a well-defined and predictable manner, which is now called <a title="Mendelian inheritance" href="http://en.wikipedia.org/wiki/Mendelian_inheritance">Mendelian inheritance</a>. His research laid the foundation for the concept of discrete heritable <a title="Trait (biology)" href="http://en.wikipedia.org/wiki/Trait_%28biology%29">traits</a>, known today as <a title="Gene" href="http://en.wikipedia.org/wiki/Gene">genes</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Pearson_2006">[19]</a> Mendel's ideas replaced the notion of "blending inheritance" prevalent at the time Darwin wrote The Origin of Species, and answered the long-standing problem of the persistence of variation within populations.Later research gave a physical basis to the notion of genes, and eventually identified <a title="DNA" href="http://en.wikipedia.org/wiki/DNA">DNA</a> as the heritable material, with genes re-defined as regions within this DNA.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Pearson_2006">[19]</a> <a title="DNA" href="http://en.wikipedia.org/wiki/DNA">DNA</a> is stored within <a title="Chromosome" href="http://en.wikipedia.org/wiki/Chromosome">chromosomes</a> in organisms and a specific location on a <a title="Chromosome" href="http://en.wikipedia.org/wiki/Chromosome">chromosome</a> is known as a <a title="Locus (genetics)" href="http://en.wikipedia.org/wiki/Locus_%28genetics%29">locus</a>, with a variant of a DNA sequence at a given locus called an <a title="Allele" href="http://en.wikipedia.org/wiki/Allele">allele</a>. DNA is not copied perfectly, and changes (mutations) in genes produce new alleles and thus affect the traits that the genes control. This simple correspondence between a gene and a trait works in many cases, although complex traits such as disease resistance are controlled by <a title="Quantitative trait locus" href="http://en.wikipedia.org/wiki/Quantitative_trait_locus">multiple interacting genes</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-13">[20]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Lin">[21]</a>Apart from mutations, other way changes in genes can influence traits is through <a title="DNA" href="http://en.wikipedia.org/wiki/DNA#Base_modifications">DNA modifications</a> such as <a title="DNA methylation" href="http://en.wikipedia.org/wiki/DNA_methylation">DNA methylation</a>, which do not change the sequence of the DNA in a gene, but cause an <a title="Epigenetics" href="http://en.wikipedia.org/wiki/Epigenetics">inherited change</a> in the use of that gene.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-14">[22]</a> Non-DNA based forms of heritable variation exist, such as transmission of the secondary structures of <a title="Prion" href="http://en.wikipedia.org/wiki/Prion">prions</a> in <a title="Yeast" href="http://en.wikipedia.org/wiki/Yeast">yeast</a>,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-15">[23]</a> or <a title="Structural inheritance" href="http://en.wikipedia.org/wiki/Structural_inheritance">structural inheritance</a> of patterns in the rows of cilia in protozoans such as Paramecium<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-16">[24]</a> and Tetrahymena.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-17">[25]</a> However, it is unclear if these mechanisms produce specific heritable changes in response to the environment. If this does occur, then some instances of evolution would be separate from standard genetic inheritance, which avoids any connection between the environment and the production of heritable variation.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-18">[26]</a> However, the processes that produce these variations are rather rare and often reversible, so their significance to evolution remains unclear.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-19">[27]</a> <h2>Variation</h2><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Genetic variation" href="http://en.wikipedia.org/wiki/Genetic_variation">Genetic variation</a> and <a title="Population genetics" href="http://en.wikipedia.org/wiki/Population_genetics">Population genetics</a>. </dd></dl></div>Variation comes from <a title="Mutation" href="http://en.wikipedia.org/wiki/Mutation">mutations</a> in <a title="Genetic material" href="http://en.wikipedia.org/wiki/Genetic_material">genetic material</a>, migration between populations (<a title="Gene flow" href="http://en.wikipedia.org/wiki/Gene_flow">gene flow</a>), and the reshuffling of genes during <a title="Sexual reproduction" href="http://en.wikipedia.org/wiki/Sexual_reproduction">sexual reproduction</a> (<a title="Genetic recombination" href="http://en.wikipedia.org/wiki/Genetic_recombination">genetic recombination</a>). In some organisms, like bacteria and plants, variation is also produced by the mixing of genetic material between different species in <a title="Horizontal gene transfer" href="http://en.wikipedia.org/wiki/Horizontal_gene_transfer">horizontal gene transfer</a> and <a title="Hybrid" href="http://en.wikipedia.org/wiki/Hybrid">hybridization</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-20">[28]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-21">[29]</a> Despite all the processes that introduce variation, most sites in the <a title="Genome" href="http://en.wikipedia.org/wiki/Genome">genome</a> of a species are identical in all individuals of this species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-22">[30]</a> However, relatively small changes in genotype can lead to dramatic changes in phenotype, with chimpanzees and humans, for example only differing in about 5% of their genomes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-23">[31]</a>The heritable portion of an individual's traits, their <a title="Phenotype" href="http://en.wikipedia.org/wiki/Phenotype">phenotype</a>, results from the interaction of their specific genetic makeup, or <a title="Genotype" href="http://en.wikipedia.org/wiki/Genotype">genotype</a> with the environment.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Lin">[21]</a> Thus, the variation in heritable traits within a population reflects the variation in this population's genetic makeup. The <a title="Modern evolutionary synthesis" href="http://en.wikipedia.org/wiki/Modern_evolutionary_synthesis">modern evolutionary synthesis</a> defines evolution as the change over time in the relative <a title="Allele frequency" href="http://en.wikipedia.org/wiki/Allele_frequency">frequencies of alleles</a> in a population.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-24">[32]</a> The frequency of these variants may fluctuate in the population, becoming more or less prevalent relative to other alleles of that gene. All evolutionary forces act by driving these changes in allele frequency in one direction or another. Variation disappears when an allele reaches the point of <a title="Fixation (population genetics)" href="http://en.wikipedia.org/wiki/Fixation_%28population_genetics%29">fixation</a> — when it either disappears from the population, or when it replaces the ancestral allele entirely.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Amos">[33]</a> <h3>Mutation</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Mutation" href="http://en.wikipedia.org/wiki/Mutation">Mutation</a>. </dd></dl></div><div class="thumb tleft"><div class="thumbinner" style="WIDTH: 152px"><a class="internal" title="Mutation can occur because of "copy errors" during DNA replication" href="http://en.wikipedia.org/wiki/Image:Dna-split.png"><img class="thumbimage" height="295" alt="Mutation can occur because of "copy errors" during DNA replication" width="150" longdesc="/wiki/Image:Dna-split.png" src="http://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Dna-split.png/150px-Dna-split.png" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Dna-split.png"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>Mutation can occur because of "copy errors" during DNA replication</div></div></div>Genetic variation arises due to <a title="Randomness" href="http://en.wikipedia.org/wiki/Randomness">random</a> mutations that occur in the <a title="Genome" href="http://en.wikipedia.org/wiki/Genome">genomes</a> of all organisms. Mutations are transmissible changes in <a title="Genetic material" href="http://en.wikipedia.org/wiki/Genetic_material">genetic material</a>, and are often caused by mutagens such as <a title="Radioactive decay" href="http://en.wikipedia.org/wiki/Radioactive_decay">radiation</a> and <a title="Mutagen" href="http://en.wikipedia.org/wiki/Mutagen">mutagenic chemicals</a>, as well as errors that occur during <a title="DNA replication" href="http://en.wikipedia.org/wiki/DNA_replication">DNA replication</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Bertram">[34]</a> <a title="Virus" href="http://en.wikipedia.org/wiki/Virus">Viruses</a> and mobile DNA sequences such as <a title="Transposon" href="http://en.wikipedia.org/wiki/Transposon">transposons</a>, are another cause of mutations.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-25">[35]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Burrus">[36]</a> In multicellular organisms, mutations can be classified into germline mutations that occur in the <a title="Gamete" href="http://en.wikipedia.org/wiki/Gamete">gametes</a> and thus can be passed onto offspring, and somatic mutations that can cause the malfunction or death of cells and can also cause <a title="Cancer" href="http://en.wikipedia.org/wiki/Cancer">cancer</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Bertram">[34]</a> Organisms have therefore evolved multiple mechanisms such as <a title="DNA repair" href="http://en.wikipedia.org/wiki/DNA_repair">DNA repair</a> that reduce mutation rates, although the optimal mutation rate for a species is a trade-off between costs such as the energy expended on DNA repair and the effects of deleterious mutations, and the benefits of advantageous mutations.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Sniegowski">[37]</a> Organisms such as bacteria can even increase their mutation rate in response to stress, leading to the evolution of novel genes that counter the source of stress.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-26">[38]</a>Individual genes can be affected by two different types of mutations. In <a title="Point mutation" href="http://en.wikipedia.org/wiki/Point_mutation">point mutations</a>, a single <a title="Base pair" href="http://en.wikipedia.org/wiki/Base_pair">base pair</a> is altered. This change in a single base pair may or may not affect the function of the gene. The other type of mutations are the deletion and insertion of base pairs. These changes usually cause a loss of the gene's function, as they cause a shift in <a title="Reading frame" href="http://en.wikipedia.org/wiki/Reading_frame">reading frame</a> and thus change many amino acid codons simultaneously.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-27">[39]</a><a title="Gene duplication" href="http://en.wikipedia.org/wiki/Gene_duplication">Gene duplications</a>, which may occur via a number of mechanisms, are believed to be one major source of raw material for evolving new genes, as tens to hundreds of genes are duplicated in animal genomes every million years.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-28">[40]</a> Most genes belong to larger <a title="Gene family" href="http://en.wikipedia.org/wiki/Gene_family">families of genes</a> that are derived from one or more ancestral genes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-29">[41]</a> Novel genes can be produced either through duplication and divergence of an ancestral gene, or the recombination of <a title="Protein domains" href="http://en.wikipedia.org/wiki/Protein_domains">protein domains</a> to form a new combination of these structural modules.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-30">[42]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-31">[43]</a> The duplication of genomes to produce <a title="Polyploidy" href="http://en.wikipedia.org/wiki/Polyploidy">polyploid</a> organisms also appears to have been important in evolution, particularly in plants.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Wendel">[44]</a>Large chromosomal rearrangements do not necessarily change gene function, but can result in reproductive isolation, and therefore cause <a title="Speciation" href="http://en.wikipedia.org/wiki/Speciation">speciation</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-32">[45]</a> An example of chromosomal rearrangements is the fusion of two chromosomes in the <a title="Homo (genus)" href="http://en.wikipedia.org/wiki/Homo_%28genus%29">Homo</a> genus that produced human chromosome 2; this fusion did not occur in the <a title="Chimpanzee" href="http://en.wikipedia.org/wiki/Chimpanzee">chimpanzee</a> <a title="Lineage (evolution)" href="http://en.wikipedia.org/wiki/Lineage_%28evolution%29">lineage</a>, and chimpanzees retain two separate chromosomes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-33">[46]</a> However, in this case, chromosomal rearrangements do not appear to have driven the divergence of the human and chimpanzee lineages.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-34">[47]</a> <h3>Recombination</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Genetic recombination" href="http://en.wikipedia.org/wiki/Genetic_recombination">Genetic recombination</a>. </dd></dl></div>In asexual organisms, variants in genes on the same chromosome will always be inherited together—they are linked, as they are joined together in the same DNA molecule. However, <a title="Sex" href="http://en.wikipedia.org/wiki/Sex">sexual</a> organisms, can exchange DNA between two matching chromosomes in a process called <a title="Genetic recombination" href="http://en.wikipedia.org/wiki/Genetic_recombination">genetic recombination</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-35">[48]</a> This shuffling of genetic material between chromosomes allows even alleles of genes that are close together in the genome to be <a title="Mendelian inheritance" href="http://en.wikipedia.org/wiki/Mendelian_inheritance#Mendel.27s_law_of_segregation">inherited independently</a>. However, the recombination rate is not very high and in humans is approximately one recombination event per 1,000,000 base pairs.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-36">[49]</a> Therefore, linked alleles are not always shuffled away from each other, but tend to be inherited together. This tendency is measured by comparing the co-occurrence of two alleles, their <a title="Linkage disequilibrium" href="http://en.wikipedia.org/wiki/Linkage_disequilibrium">linkage disequilibrium</a>. A set of alleles that are often inherited together is called a <a title="Haplotype" href="http://en.wikipedia.org/wiki/Haplotype">haplotype</a> and this co-inheritance can indicate that the locus is under positive selection.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-37">[50]</a>Recombination in sexual organisms allows disadvantageous mutations to be purged and beneficial mutations to be retained more efficiently than in asexual organisms.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Otto">[51]</a> However, recombination can also lead to more individuals with new and advantageous gene combinations being produced. These benefits can be identified by looking at the effects of situations where alleles cannot be separated by recombination (for example in mammalian <a title="Y chromosome" href="http://en.wikipedia.org/wiki/Y_chromosome">Y chromosomes</a>).<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-38">[52]</a> In these situations, there is a reduction in <a title="Effective population size" href="http://en.wikipedia.org/wiki/Effective_population_size">effective population size</a> called the <a title="Hill-Robertson effect" href="http://en.wikipedia.org/wiki/Hill-Robertson_effect">Hill-Robertson effect</a>,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-39">[53]</a> which causes the <a title="Muller's ratchet" href="http://en.wikipedia.org/wiki/Muller%27s_ratchet">accumulation of deleterious mutations</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-40">[54]</a> These positive effects of recombination are balanced by the facts that it can cause mutations (as it involves the breaking and rejoining of the DNA strands) and it can also separate gene combinations that have been successful in previous generations.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Otto">[51]</a> The optimal rate of recombination for a species is therefore a trade-off between these conflicting factors. <h3>Gene flow</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Gene flow" href="http://en.wikipedia.org/wiki/Gene_flow">Gene flow</a>, <a title="Hybrid" href="http://en.wikipedia.org/wiki/Hybrid">Hybrid</a>, and <a title="Horizontal gene transfer" href="http://en.wikipedia.org/wiki/Horizontal_gene_transfer">Horizontal gene transfer</a>. </dd></dl></div><div class="thumb tright"><div class="thumbinner" style="WIDTH: 352px"><a class="internal" title="Map of the world showing distribution of camelids. Solid black lines indicate possible migration routes." href="http://en.wikipedia.org/wiki/Image:Evolution_evi_mig.png"><img class="thumbimage" height="180" alt="Map of the world showing distribution of camelids. Solid black lines indicate possible migration routes." width="350" longdesc="/wiki/Image:Evolution_evi_mig.png" src="http://upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Evolution_evi_mig.png/350px-Evolution_evi_mig.png" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Evolution_evi_mig.png"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>Map of the world showing distribution of <a title="Camelid" href="http://en.wikipedia.org/wiki/Camelid">camelids</a>. Solid black lines indicate possible migration routes.</div></div></div><a title="Gene flow" href="http://en.wikipedia.org/wiki/Gene_flow">Gene flow</a> is the exchange of genes between populations, most commonly of the same species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-41">[55]</a> Examples include the migration of organisms and the exchange of <a title="Pollen" href="http://en.wikipedia.org/wiki/Pollen">pollen</a> within a species, as well as hybridization and horizontal gene transfer between species.<a title="Migration" href="http://en.wikipedia.org/wiki/Migration">Migration</a> into or out of a population can change allele frequencies. Immigration may add new genetic material to the established <a title="Gene pool" href="http://en.wikipedia.org/wiki/Gene_pool">gene pool</a> of a population. Conversely, emigration may remove genetic material. As <a title="Reproductive isolation" href="http://en.wikipedia.org/wiki/Reproductive_isolation">reproductive isolation</a> is required for <a title="Speciation" href="http://en.wikipedia.org/wiki/Speciation">speciation</a>, gene flow may delay speciation by homogenizing two diverging populations. Gene flow is hindered by impassable mountain ranges, oceans and deserts or even the <a title="Great Wall of China" href="http://en.wikipedia.org/wiki/Great_Wall_of_China">Great Wall of China</a>, which has hindered the flow of plant genes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-42">[56]</a>Depending on how far two species have diverged since their <a title="Last common ancestor" href="http://en.wikipedia.org/wiki/Last_common_ancestor">last common ancestor</a>, it may still be possible for them to produce viable offspring, as with <a title="Horse" href="http://en.wikipedia.org/wiki/Horse">horses</a> and <a title="Donkey" href="http://en.wikipedia.org/wiki/Donkey">donkeys</a> mating to produce <a title="Mule" href="http://en.wikipedia.org/wiki/Mule">mules</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-43">[57]</a> Such <a title="Hybrid" href="http://en.wikipedia.org/wiki/Hybrid">hybrids</a> are generally <a title="Infertility" href="http://en.wikipedia.org/wiki/Infertility">infertile</a>, due to mispairings of chromosomes during <a title="Meiosis" href="http://en.wikipedia.org/wiki/Meiosis">meiosis</a>. In this case, closely-related species may regularly interbreed, but hybrids will be selected against and the populations will remain distinct. This has been noted in toads, butterflies, clams and mussels. Selection against hybrids may produce traits that increase reluctance to mate outside the species and <a title="Character displacement" href="http://en.wikipedia.org/wiki/Character_displacement">character displacement</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-44">[58]</a> However, viable hybrids can also be formed and these new species can either have properties intermediate between their parent species, or a radically different phenotype.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-45">[59]</a> Although hybridization rarely leads to <a title="Hybrid speciation" href="http://en.wikipedia.org/wiki/Hybrid_speciation">new species</a> in animals, this is an important means of speciation in plants.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Wendel">[44]</a> <a title="Polyploidy" href="http://en.wikipedia.org/wiki/Polyploidy">Polyploidy</a>, having more than two copies of each chromosome, is tolerated in plants more readily than in animals. The major advantage to a hybrid becoming polyploid is that it allows reproduction, as the different sets of chromosomes will be able to pair during meiosis.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-46">[60]</a> Polypolids also have more genetic diversity, which allows them to resist the effects of <a title="Inbreeding" href="http://en.wikipedia.org/wiki/Inbreeding">inbreeding</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-47">[61]</a>Horizontal gene transfer is the transfer of genetic material from one organism to another organism that is not its offspring. Horizontal gene transfer is common among <a title="Bacterium" href="http://en.wikipedia.org/wiki/Bacterium">bacteria</a>, even very distantly-related species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-48">[62]</a> In medicine, this contributes to the spread of <a title="Antibiotic resistance" href="http://en.wikipedia.org/wiki/Antibiotic_resistance">antibiotic resistance</a>, as when one bacteria acquires resistance genes it can transfer them to many other species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-49">[63]</a> Horizontal transfer of genes from bacteria to eukaryotes such as the yeast <a title="Saccharomyces cerevisiae" href="http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae">Saccharomyces cerevisiae</a> and the adzuki bean beetle Callosobruchus chinensis may also have occurred.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-50">[64]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-51">[65]</a> <a title="Virus" href="http://en.wikipedia.org/wiki/Virus">Viruses</a> can also carry DNA between organisms, allowing transfer of genes even across <a title="Domain (biology)" href="http://en.wikipedia.org/wiki/Domain_%28biology%29">biological domains</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-52">[66]</a>Horizontal gene transfer has also occurred within <a title="Eukaryote" href="http://en.wikipedia.org/wiki/Eukaryote">eukaryotes</a>, from their chloroplast and mitochondrial genome to their nuclear genome.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-53">[67]</a> According to <a title="Endosymbiotic theory" href="http://en.wikipedia.org/wiki/Endosymbiotic_theory">endosymbiotic theory</a>, chloroplasts and mitochondria probably originated as bacterial <a title="Endosymbiont" href="http://en.wikipedia.org/wiki/Endosymbiont">endosymbionts</a> of a progenitor to the eukaryotic cell.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Dyall">[68]</a> Horizontal gene transfer complicates <a title="Phylogenetics" href="http://en.wikipedia.org/wiki/Phylogenetics">phylogenetics</a>, since it produces genetic connections between distantly-related species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-54">[69]</a> <h2>Mechanisms of evolution</h2>The two basic mechanisms of evolutionary change—the change in <a title="Allele frequency" href="http://en.wikipedia.org/wiki/Allele_frequency">allele frequencies</a> within a population—are genetic drift and natural selection. Genetic drift is the random sampling of a parent generation's genes, which causes some alleles to randomly change in frequency. Natural selection, on the other hand, is the nonrandom propagation of genes that favor survival and reproduction. <h3>Genetic drift</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Genetic drift" href="http://en.wikipedia.org/wiki/Genetic_drift">Genetic drift</a> and <a title="Effective population size" href="http://en.wikipedia.org/wiki/Effective_population_size">Effective population size</a>. </dd></dl></div>Genetic drift is the change in allele frequency from one generation to the next that occurs because alleles in the offspring generation are a <a title="Sampling (statistics)" href="http://en.wikipedia.org/wiki/Sampling_%28statistics%29">random sample</a> of alleles in the parent generation, and are thus subject to <a title="Sampling error" href="http://en.wikipedia.org/wiki/Sampling_error">sampling error</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Amos">[33]</a> Over time, even in the absence of selection on the alleles, allele frequencies tend to "drift" upward or downward, until they eventually becoming "fixed" - that is, going to 0% or 100% frequency. Fluctuations in allele frequency between successive generations may thus result in some alleles disappearing from the population due to chance alone. Two separate populations that begin with the same allele frequencies might therefore drift apart by random fluctuation into two divergent populations with different sets of alleles.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-55">[70]</a>The relative importance of natural selection and genetic drift in determining the fate of new mutations depends on the population size and the strength of selection.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Whitlock">[71]</a> Natural selection is predominant in large populations, while genetic drift is dominant in small populations. Finally, the time for an allele to become fixed in the population by genetic drift (that is, for all individuals in the population to carry that allele) depends on population size — smaller populations require a shorter time for fixation.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-56">[72]</a>As a result, changing population size can dramatically influence the course of evolution. <a title="Population bottleneck" href="http://en.wikipedia.org/wiki/Population_bottleneck">Population bottlenecks</a>, where the population shrinks in size temporarily to a small number of individuals and therefore loses much genetic variation, result in a more uniform population and the loss of most rare variation.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Amos">[33]</a> Bottlenecks may also result from migration or population subdivision.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Whitlock">[71]</a> <h3>Natural selection</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Natural selection" href="http://en.wikipedia.org/wiki/Natural_selection">Natural selection</a>. </dd></dl></div><div class="thumb tright"><div class="thumbinner" style="WIDTH: 252px"><a class="internal" title="A peacock's tail is the canonical example of sexual selection" href="http://en.wikipedia.org/wiki/Image:Peacock.displaying.better.800pix.jpg"><img class="thumbimage" height="199" alt="A peacock's tail is the canonical example of sexual selection" width="250" longdesc="/wiki/Image:Peacock.displaying.better.800pix.jpg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/4/49/Peacock.displaying.better.800pix.jpg/250px-Peacock.displaying.better.800pix.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Peacock.displaying.better.800pix.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>A <a title="Peacock" href="http://en.wikipedia.org/wiki/Peacock">peacock</a>'s tail is the canonical example of <a title="Sexual selection" href="http://en.wikipedia.org/wiki/Sexual_selection">sexual selection</a></div></div></div><a title="Natural selection" href="http://en.wikipedia.org/wiki/Natural_selection">Natural selection</a>, one of the processes that drive evolution, results from the difference in reproductive success between individuals in a population.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Darwin">[73]</a> It has often been called a "self-evident" mechanism because it necessarily follows from the following facts:<dl><dd><ul> <li>Natural, heritable variation exists within populations and among species </li> <li>Organisms are superfecund (produce more offspring than can possibly survive) </li> <li>Organisms in a population vary in their ability to survive and reproduce </li> <li>In any generation, successful reproducers pass their heritable traits to the next generation, while unsuccessful reproducers do not. </li></ul></dd></dl>If a trait increases the <a title="Fitness (biology)" href="http://en.wikipedia.org/wiki/Fitness_%28biology%29">evolutionary fitness</a> of the individuals that carry them, then those individuals will be more likely to survive and reproduce than other organisms in the population, thus passing more copies of this heritable trait on to the next generation. Conversely, a decrease in fitness caused by a deleterious trait results in this trait becoming rarer.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Futuyma">[1]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-57">[74]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-58">[75]</a>A special case of natural selection is <a title="Sexual selection" href="http://en.wikipedia.org/wiki/Sexual_selection">sexual selection</a>: selection for any trait whose presence is directly correlated with mating success due to preferential mate choice.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-59">[76]</a> Traits that evolved via <a title="Sexual selection" href="http://en.wikipedia.org/wiki/Sexual_selection">sexual selection</a> are particularly prominent among males of animal species. Despite the fact that such traits may decrease the survival of individual males (e.g. cumbersome antlers, mating calls or bright colors that attract predators, male-male fighting over access to mates),<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-60">[77]</a> reproductive success is usually higher in males that show robust, sexually selected phenotypes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-61">[78]</a>Natural selection of trait frequencies within a population can be subcategorized into three different modes: <a title="Directional selection" href="http://en.wikipedia.org/wiki/Directional_selection">directional selection</a> (a shift in the mean trait value over time);<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-62">[79]</a> <a title="Disruptive selection" href="http://en.wikipedia.org/wiki/Disruptive_selection">disruptive selection</a> (selection for extreme trait values on both ends, or "tails" of the distribution, often resulting in a <a title="Bimodal distribution" href="http://en.wikipedia.org/wiki/Bimodal_distribution">bimodal distribution</a> and selection against the mean); and <a title="Stabilizing selection" href="http://en.wikipedia.org/wiki/Stabilizing_selection">stabilizing selection</a> (also called purifying selection — selection against extreme trait values on both ends, and a decrease in <a title="Variance" href="http://en.wikipedia.org/wiki/Variance">variance</a> around the mean.)<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-63">[80]</a> <h2>Outcomes of evolution</h2> <h3>Adaptation</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Adaptation" href="http://en.wikipedia.org/wiki/Adaptation">Adaptation</a>. </dd></dl></div>Through the process of natural selection, organisms generally become better suited to their environments.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Darwin">[73]</a> As a result of increased fitness, natural selection can result in <a title="Adaptation" href="http://en.wikipedia.org/wiki/Adaptation">adaptation</a> over time: the gradual accumulation of new traits that generally result in a population of organisms becoming better suited to its environment and <a title="Ecological niche" href="http://en.wikipedia.org/wiki/Ecological_niche">ecological niche</a>. <a title="Adaptation" href="http://en.wikipedia.org/wiki/Adaptation">Adaptation</a> is often thought of as any evolutionary process that increases the <a title="Fitness (biology)" href="http://en.wikipedia.org/wiki/Fitness_%28biology%29">fitness</a> of the individual — however, under such a loose definition all natural selection would be considered adaptive. More strictly speaking, an adaptation is a specifically defined trait that not only enhances performance of some specific function, but also evolved under selection to perform that function (in other words, historical function must be the same as the current utility).<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-64">[81]</a>It is important to note that not all characteristics of an organism are necessarily adaptations, as many traits are present in organisms simply by virtue of ancestry or developmental constraints. For example, whereas the human hand is very capable and seemingly well-adapted for operating a <a title="Computer mouse" href="http://en.wikipedia.org/wiki/Computer_mouse">computer mouse</a>, it is not an adaptation for that function since it did not evolve in a context where operating a mouse resulted in an increase of fitness. <a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-understandingevolution">[4]</a> Many traits that appear to be adaptations are in fact <a title="Exaptation" href="http://en.wikipedia.org/wiki/Exaptation">exaptations</a>—traits that originally evolved under selection for one function, but were later co-opted for something else.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-65">[82]</a> For example, the forelimbs of penguins were functionally wings before they evolved to function as aquatic flippers. <a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-66">[83]</a> Additionally, adaptation has no objective or absolute value: a trait that increases fitness in one environment may decrease it in another. For example, light pigmentation is an advantageous adaptation for <a title="Camouflage" href="http://en.wikipedia.org/wiki/Camouflage">camouflage</a> in light-colored habitats, but disadvantageous in dark-colored environments.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-67">[84]</a> <h3>Competition and cooperation</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Reciprocity (evolution)" href="http://en.wikipedia.org/wiki/Reciprocity_%28evolution%29">Reciprocity (evolution)</a> and <a title="Altruism in animals" href="http://en.wikipedia.org/wiki/Altruism_in_animals">Altruism in animals</a>. </dd></dl></div>One of the most striking features of the natural world is that genes, cells, and organisms cooperate to make higher-order entities function. For example, cells in the human body do not generally grow uncontrollably as when they do, this causes cancer.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-Bertram">[34]</a> Generally, mathematical models incorporating mutation and natural selection have been used to model adaptation and evolution. Recent trends now incorporate "<a title="Game theory" href="http://en.wikipedia.org/wiki/Game_theory">game theory</a>" as more applicable to generating reliable models.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-68">[85]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-69">[86]</a> Cooperation is now seen as a fundamental property needed for evolution to construct new levels of organization. That selfish replicators could sacrifice their own reproductive potential to cooperate seems paradoxical in a competitive world, however a number of mechanisms can generate cooperation, such as kin selection, direct reciprocity, indirect reciprocity, network reciprocity, and group selection.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-70">[87]</a> The ubiquity of cooperation in the natural world and studies from the last twenty-five years reveal cooperation as a significant principle in constructive evolution and it is now recognised as the third fundamental principle in evolution, alongside variation and selection.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-71">[88]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-72">[89]</a> <h3>Speciation and extinction</h3><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Speciation" href="http://en.wikipedia.org/wiki/Speciation">Speciation</a> and <a title="Extinction" href="http://en.wikipedia.org/wiki/Extinction">Extinction</a>. </dd></dl></div><div class="thumb tright"><div class="thumbinner" style="WIDTH: 252px"><a class="internal" title="The geographical isolation of Darwin's finches on the Galápagos Islands led to the rise of over a dozen distinct species. Their beak shapes reflect adaptations to many different food sources." href="http://en.wikipedia.org/wiki/Image:Darwin%27s_finches.jpeg"><img class="thumbimage" height="236" alt="The geographical isolation of Darwin's finches on the Galápagos Islands led to the rise of over a dozen distinct species. Their beak shapes reflect adaptations to many different food sources." width="250" longdesc="/wiki/Image:Darwin%27s_finches.jpeg" src="http://upload.wikimedia.org/wikipedia/commons/9/97/Darwin%27s_finches.jpeg" /></a><div class="thumbcaption">The <a title="Geographical isolation" href="http://en.wikipedia.org/wiki/Geographical_isolation">geographical isolation</a> of <a title="Darwin's finches" href="http://en.wikipedia.org/wiki/Darwin%27s_finches">Darwin's finches</a> on the <a title="Galápagos Islands" href="http://en.wikipedia.org/wiki/Gal%C3%A1pagos_Islands">Galápagos Islands</a> led to the rise of over a dozen distinct species. Their beak shapes reflect adaptations to many different food sources.</div></div></div><a title="Speciation" href="http://en.wikipedia.org/wiki/Speciation">Speciation</a> is the irreversible process by which a pre-existing species lineage diverges into two descendant (or "daughter") species lineages, which then become reproductively isolated.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-73">[90]</a> Speciation is always described and understood as a binary (two-part) split in genealogy. Because a pair of sister species are equally descended from the ancestral form, it is incorrect to view one daughter species as the "original" species and the other as the "new" one.In sexually reproducing organisms, speciation results from two important events: 1.) the evolution of reproductive isolating mechanisms, resulting in 2.) genealogical divergence. The most common mode of speciation in animals is <a title="Allopatric speciation" href="http://en.wikipedia.org/wiki/Allopatric_speciation">allopatric speciation</a>, which occurs in populations that initially become isolated geographically, such as by <a title="Habitat fragmentation" href="http://en.wikipedia.org/wiki/Habitat_fragmentation">habitat fragmentation</a> or migration. Simply by virtue of being geographically separated, selection and drift will act independently in the isolated populations, and will proceed to reproductive incompatibility if the separation is maintained long enough.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-74">[91]</a> <a title="Sympatric speciation" href="http://en.wikipedia.org/wiki/Sympatric_speciation">Sympatric speciation</a> is species divergence without geographic isolation, and it is typically controversial since even a small amount of <a title="Gene flow" href="http://en.wikipedia.org/wiki/Gene_flow">gene flow</a> may be sufficient to homogenize a potentially diverging species.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-75">[92]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-76">[93]</a> General models of sympatric speciation require the evolution of stable <a title="Polymorphism (biology)" href="http://en.wikipedia.org/wiki/Polymorphism_%28biology%29">polymorphisms</a> associated with non-random <a title="Assortative mating" href="http://en.wikipedia.org/wiki/Assortative_mating">assortative mating</a>, in order for reproductive isolation to evolve. An example of rapid sympatric speciation can be clearly observed in the <a title="Triangle of U" href="http://en.wikipedia.org/wiki/Triangle_of_U">triangle of U</a>, where new species of Brassica sp. have been made by the fusing of separate genomes from related plants, although this type of speciation may be more accurately described as speciation by <a title="Polyploidy" href="http://en.wikipedia.org/wiki/Polyploidy">polyploidization</a>.<div class="thumb tleft"><div class="thumbinner" style="WIDTH: 227px"><a class="internal" title="An Allosaurus skeleton. All non-avian dinosaur species died in a mass extinction." href="http://en.wikipedia.org/wiki/Image:Allosaurus1.jpg"><img class="thumbimage" height="169" alt="An Allosaurus skeleton. All non-avian dinosaur species died in a mass extinction." width="225" longdesc="/wiki/Image:Allosaurus1.jpg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/d7/Allosaurus1.jpg/225px-Allosaurus1.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Allosaurus1.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>An <a title="Allosaurus" href="http://en.wikipedia.org/wiki/Allosaurus">Allosaurus</a> skeleton. All non-avian <a title="Dinosaur" href="http://en.wikipedia.org/wiki/Dinosaur">dinosaur</a> species died in a <a title="Permian-Triassic extinction event" href="http://en.wikipedia.org/wiki/Permian-Triassic_extinction_event">mass extinction</a>.</div></div></div><a title="Ernst Mayr" href="http://en.wikipedia.org/wiki/Ernst_Mayr">Ernst Mayr</a>'s <a title="Peripatric speciation" href="http://en.wikipedia.org/wiki/Peripatric_speciation">peripatric speciation</a> is a type of speciation that exists as a result of <a title="Character displacement" href="http://en.wikipedia.org/wiki/Character_displacement">character displacement</a> on hybrid-zone boundaries between two adjoining populations. Peripatric speciation is a critical underpinning of the theory of <a title="Punctuated equilibrium" href="http://en.wikipedia.org/wiki/Punctuated_equilibrium">punctuated equilibrium</a>.One common misconception about evolution is the idea that if humans evolved from monkeys, monkeys should no longer exist. However, biologists have never claimed that humans evolved from monkeys — only that humans and monkeys, like all organisms, share a common ancestor (that was neither human nor monkey).<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-77">[94]</a>Common misconceptions like this indicate a misunderstanding of speciation, which involves two subsets of a population <a title="Cladogenesis" href="http://en.wikipedia.org/wiki/Cladogenesis">cladogenetically</a> splitting apart, rather than an entire species simply turning into a new one.<a title="Extinction" href="http://en.wikipedia.org/wiki/Extinction">Extinction</a> is the disappearance of species (i.e., <a title="Gene pool" href="http://en.wikipedia.org/wiki/Gene_pool">gene pools</a>). The moment of extinction is generally defined as occurring at the death of the last individual of that species. Extinction is not an unusual event on a <a title="Geological time scale" href="http://en.wikipedia.org/wiki/Geological_time_scale">geological time scale</a> — species regularly appear through speciation, and disappear through extinction. The <a title="Permian-Triassic extinction event" href="http://en.wikipedia.org/wiki/Permian-Triassic_extinction_event">Permian-Triassic extinction event</a> was the Earth's most severe <a title="Extinction event" href="http://en.wikipedia.org/wiki/Extinction_event">extinction event</a>, rendering extinct 90% of all marine species and 70% of all terrestrial vertebrate species. In the <a title="Cretaceous-Tertiary extinction event" href="http://en.wikipedia.org/wiki/Cretaceous-Tertiary_extinction_event">Cretaceous-Tertiary extinction event</a>, many forms of life perished (including approximately 50% of all <a title="Genus" href="http://en.wikipedia.org/wiki/Genus">genera</a>), the most commonly mentioned among them being the non-avian <a title="Dinosaur" href="http://en.wikipedia.org/wiki/Dinosaur">dinosaurs</a>. The <a title="Holocene extinction event" href="http://en.wikipedia.org/wiki/Holocene_extinction_event">Holocene extinction event</a> is a current mass extinction, involving the rapid extinction of tens or hundreds of thousands of species each year. Scientists consider human activities to be the primary cause of the ongoing extinction event, as well as the related influence of <a title="Climate change" href="http://en.wikipedia.org/wiki/Climate_change">climate change</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-78">[95]</a> <h2>Evidence of evolution</h2><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Evidence of evolution" href="http://en.wikipedia.org/wiki/Evidence_of_evolution">Evidence of evolution</a> and <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">Common descent</a>. </dd></dl></div> <h3>Common descent</h3>The theory of universal <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">common descent</a> proposes that all <a title="Organisms" href="http://en.wikipedia.org/wiki/Organisms">organisms</a> on <a title="Earth" href="http://en.wikipedia.org/wiki/Earth">Earth</a> are descended from a common ancestor or ancestral <a title="Gene pool" href="http://en.wikipedia.org/wiki/Gene_pool">gene pool</a>. Evidence for common descent is inferred from traits shared between all living organisms. Today, there is strong evidence from genetics that all organisms have a common ancestor. For example, every living cell makes use of <a title="Nucleic acid" href="http://en.wikipedia.org/wiki/Nucleic_acid">nucleic acids</a> as its genetic material, and uses the same 20 <a title="Amino acid" href="http://en.wikipedia.org/wiki/Amino_acid">amino acids</a> as the building blocks for <a title="Protein" href="http://en.wikipedia.org/wiki/Protein">proteins</a>. The universality of these traits strongly suggests common ancestry, because the selection of many of these traits seems arbitrary. <a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-79">[96]</a><div class="thumb tleft"><div class="thumbinner" style="WIDTH: 302px"><a class="internal" title="Morphologic similarities in the Hominidae family are evidence of common descent." href="http://en.wikipedia.org/wiki/Image:Huxley_-_Mans_Place_in_Nature.jpg"><img class="thumbimage" height="180" alt="Morphologic similarities in the Hominidae family are evidence of common descent." width="300" longdesc="/wiki/Image:Huxley_-_Mans_Place_in_Nature.jpg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/Huxley_-_Mans_Place_in_Nature.jpg/300px-Huxley_-_Mans_Place_in_Nature.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Huxley_-_Mans_Place_in_Nature.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>Morphologic similarities in the <a title="Hominidae" href="http://en.wikipedia.org/wiki/Hominidae">Hominidae</a> family are evidence of common descent.</div></div></div>In the <a title="Origin of Species" href="http://en.wikipedia.org/wiki/Origin_of_Species">Origin of Species</a>, Darwin built his case for the truth of shared ancestry of all organisms by pointing out a number of facts that were not new to science: 1.) organisms have geographic distributions that cannot be explained by local ecology or adaptation alone. 2.) The diversity of life is not a diversity of completely unique organisms, but a diversity of organisms that share traits and similarities with one another (see <a title="Homology" href="http://en.wikipedia.org/wiki/Homology">homology</a>). 3.) Many organisms have vestigial traits or even behaviors that have no clear purpose in their modern bearers. 4.) All of life, as <a title="Linneaus" href="http://en.wikipedia.org/wiki/Linneaus">Linneaus</a> and others have always recognized, can be naturally classified into a hierarchy of nested groups. This last point in particular is strongly consistent with a shared evolutionary history of all organisms that live today and ever lived.Evolution has also left numerous signs of the histories of different species. <a title="Fossil" href="http://en.wikipedia.org/wiki/Fossil">Fossils</a>, along with the <a title="Comparative anatomy" href="http://en.wikipedia.org/wiki/Comparative_anatomy">comparative anatomy</a> of present-day organisms, constitute the morphological, or <a title="Anatomy" href="http://en.wikipedia.org/wiki/Anatomy">anatomical</a>, record. By comparing the anatomies of both modern and extinct species, paleontologists can infer the lineages of those species.The development of <a title="Molecular genetics" href="http://en.wikipedia.org/wiki/Molecular_genetics">molecular genetics</a>, and particularly of DNA sequencing, has allowed biologists to study the record of evolution left in organisms' genetic structures. The degrees of similarity and difference in the DNA sequences of modern species allows geneticists to reconstruct their lineages. It is from DNA sequence comparisons that figures such as the 96% genotypic similarity between humans and chimpanzees are obtained.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-80">[97]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-81">[98]</a><div class="thumb tright"><div class="thumbinner" style="WIDTH: 302px"><a class="internal" title="Tiktaalik in context: one of many species that track the evolutionary development of fish fins into tetrapod limbs" href="http://en.wikipedia.org/wiki/Image:Fishapods.jpg"><img class="thumbimage" height="153" alt="Tiktaalik in context: one of many species that track the evolutionary development of fish fins into tetrapod limbs" width="300" longdesc="/wiki/Image:Fishapods.jpg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/db/Fishapods.jpg/300px-Fishapods.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Fishapods.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div><a title="Tiktaalik" href="http://en.wikipedia.org/wiki/Tiktaalik">Tiktaalik</a> in context: one of many species that track the evolutionary development of fish fins into tetrapod limbs</div></div></div>Other evidence used to demonstrate evolutionary lineages includes the geographical distribution of species. For instance, <a title="Marsupial" href="http://en.wikipedia.org/wiki/Marsupial">marsupials</a> are found only in Australia and South America, showing that their common ancestor with placental mammals lived before the breakup of <a title="Gondwana" href="http://en.wikipedia.org/wiki/Gondwana">Gondwana</a> and the freezing over of <a title="Antarctica" href="http://en.wikipedia.org/wiki/Antarctica">Antarctica</a>.Scientists correlate all of the above evidence, drawn from <a title="Paleontology" href="http://en.wikipedia.org/wiki/Paleontology">paleontology</a>, anatomy, genetics, and geography, with other information about the <a title="History of Earth" href="http://en.wikipedia.org/wiki/History_of_Earth">history of Earth</a>. For instance, <a title="Paleoclimatology" href="http://en.wikipedia.org/wiki/Paleoclimatology">paleoclimatology</a> attests to periodic <a title="Ice age" href="http://en.wikipedia.org/wiki/Ice_age">ice ages</a> during which the world's climate was much cooler, and these are often found to match up with the spread of species which are better-equipped to deal with the cold, such as the <a title="Woolly mammoth" href="http://en.wikipedia.org/wiki/Woolly_mammoth">woolly mammoth</a>. <h3>Morphological homology</h3><a title="Fossil" href="http://en.wikipedia.org/wiki/Fossil">Fossils</a> are critical evidence for estimating when various lineages originated. Since fossilization of an organism is an uncommon occurrence, usually requiring hard parts (like teeth, bone, or pollen), the fossil record provides only sparse and intermittent information about ancestral lineages.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-82">[99]</a>The fossil record provides several types of data important to the study of evolution. First, the fossil record contains the earliest known examples of life itself, as well as the earliest occurrences of individual <a title="Lineage (evolution)" href="http://en.wikipedia.org/wiki/Lineage_%28evolution%29">lineages</a>. For example, the first complex animals date from the <a title="Early Cambrian" href="http://en.wikipedia.org/wiki/Early_Cambrian">early Cambrian</a> period, approximately 520 million years ago. Second, the records of individual species yield information regarding the patterns and rates of evolution, showing whether, for example, speciation occurs gradually and incrementally, or in relatively brief intervals of geologic time. Thirdly, the fossil record is a document of large-scale patterns and events in the history of life. For example, <a title="Extinction event" href="http://en.wikipedia.org/wiki/Extinction_event">mass extinctions</a> frequently resulted in the loss of entire groups of species, while leaving others relatively unscathed. Recently, molecular biologists have used the time since divergence of related lineages to calibrate the rate at which mutations accumulate, and at which the <a title="Genomes" href="http://en.wikipedia.org/wiki/Genomes">genomes</a> of different lineages evolve.<div class="thumb tright"><div class="thumbinner" style="WIDTH: 352px"><a class="internal" title="Letter c in the picture indicates the undeveloped hind legs of a baleen whale, vestigial remnants of its terrestrial ancestors" href="http://en.wikipedia.org/wiki/Image:Skelett_vom_Wal_MK1888_ohne_Text.gif"><img class="thumbimage" height="107" alt="Letter c in the picture indicates the undeveloped hind legs of a baleen whale, vestigial remnants of its terrestrial ancestors" width="350" longdesc="/wiki/Image:Skelett_vom_Wal_MK1888_ohne_Text.gif" src="http://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Skelett_vom_Wal_MK1888_ohne_Text.gif/350px-Skelett_vom_Wal_MK1888_ohne_Text.gif" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Skelett_vom_Wal_MK1888_ohne_Text.gif"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>Letter c in the picture indicates the undeveloped hind legs of a <a title="Baleen whale" href="http://en.wikipedia.org/wiki/Baleen_whale">baleen whale</a>, <a title="Vestigial structure" href="http://en.wikipedia.org/wiki/Vestigial_structure">vestigial</a> remnants of its terrestrial ancestors</div></div></div><a title="Phylogenetics" href="http://en.wikipedia.org/wiki/Phylogenetics">Phylogenetics</a>, the study of the ancestry of species, has revealed that structures with similar internal organization may perform divergent functions. <a title="Vertebrate" href="http://en.wikipedia.org/wiki/Vertebrate">Vertebrate</a> limbs are a common example of such <a title="Homology (biology)" href="http://en.wikipedia.org/wiki/Homology_%28biology%29">homologous</a> structures. The bones within bat wings, for example, are very structurally similar to human hands due to common descent of these structures from an ancestor that also had 5 digits at the end of each forelimb. Other idiosyncratic anatomical features such as the panda's "<a title="Sesamoid bone" href="http://en.wikipedia.org/wiki/Sesamoid_bone">thumb</a>" indicate how an organism's evolutionary lineage constrains its adaptive development. Vestigial structures include the degenerate eyes of blind cave-dwelling fish, and the presence of hip bones in whales and snakes. Such structures may exist with little or no function in a more current organism, yet have a clear function in an ancestral species. Examples of vestigial structures in humans include <a title="Wisdom teeth" href="http://en.wikipedia.org/wiki/Wisdom_teeth">wisdom teeth</a>, the <a title="Coccyx" href="http://en.wikipedia.org/wiki/Coccyx">coccyx</a> and the <a title="Vermiform appendix" href="http://en.wikipedia.org/wiki/Vermiform_appendix">vermiform appendix</a>.These anatomical similarities in extant and fossil organisms can give evidence of the relationships between different groups of organisms. Important fossil evidence includes the connection of distinct classes of organisms by so-called "<a title="Transitional fossil" href="http://en.wikipedia.org/wiki/Transitional_fossil">transitional</a>" species, such as the <a title="Archaeopteryx" href="http://en.wikipedia.org/wiki/Archaeopteryx">Archaeopteryx</a>, which provided early evidence for intermediate species between <a title="Dinosaur" href="http://en.wikipedia.org/wiki/Dinosaur">dinosaurs</a> and <a title="Bird" href="http://en.wikipedia.org/wiki/Bird">birds</a>,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-83">[100]</a> and the recently-discovered <a title="Tiktaalik" href="http://en.wikipedia.org/wiki/Tiktaalik">Tiktaalik</a>, which clarifies the development from <a title="Fish" href="http://en.wikipedia.org/wiki/Fish">fish</a> to <a title="Tetrapod" href="http://en.wikipedia.org/wiki/Tetrapod">animals with four limbs</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-84">[101]</a> <h3>Molecular homology</h3>By comparing the genetic and/or protein sequences of species, we can discern their evolutionary relationships. The resultant <a title="Phylogenetic tree" href="http://en.wikipedia.org/wiki/Phylogenetic_tree">phylogenetic trees</a> are typically congruent with traditional taxonomy, and are often used to either strengthen or correct taxonomic classifications. Sequence comparison is considered a measure robust enough to be used to correct erroneous assumptions in the phylogenetic tree in instances where other evidence is scarce. For example, neutral human DNA sequences are approximately 1.2% divergent (based on substitutions) from those of their nearest genetic relative, the <a title="Chimpanzee" href="http://en.wikipedia.org/wiki/Chimpanzee">chimpanzee</a>, 1.6% from <a title="Gorilla" href="http://en.wikipedia.org/wiki/Gorilla">gorillas</a>, and 6.6% from <a title="Baboon" href="http://en.wikipedia.org/wiki/Baboon">baboons</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-85">[102]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-86">[103]</a> Genetic sequence evidence thus allows inference and quantification of genetic relatedness between humans and other apes.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-c">[104]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-87">[105]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-88">[106]</a> The sequence of the 16S <a title="RRNA" href="http://en.wikipedia.org/wiki/RRNA">rRNA</a> gene, a vital gene encoding a part of the <a title="Ribosome" href="http://en.wikipedia.org/wiki/Ribosome">ribosome</a>, was used to find the broad phylogenetic relationships between all extant life. This analysis, originally done by <a title="Carl Woese" href="http://en.wikipedia.org/wiki/Carl_Woese">Carl Woese</a>, resulted in the <a title="Three-domain system" href="http://en.wikipedia.org/wiki/Three-domain_system">three-domain system</a>, arguing for two major splits in the early evolution of life. The first split led to modern <a title="Bacteria" href="http://en.wikipedia.org/wiki/Bacteria">bacteria</a>, and the subsequent split led to modern <a title="Archaea" href="http://en.wikipedia.org/wiki/Archaea">archaea</a> and <a title="Eukaryote" href="http://en.wikipedia.org/wiki/Eukaryote">eukaryotes</a>.Since <a title="Metabolism" href="http://en.wikipedia.org/wiki/Metabolism">metabolic</a> processes do not leave fossils, research into the evolution of the basic cellular processes is done largely by comparison of existing organisms. Many lineages diverged when new metabolic processes appeared, and it is theoretically possible to determine when certain metabolic processes appeared by comparing the traits of the descendants of a common ancestor or by detecting their physical manifestations. For example, the appearance of oxygen in the earth's atmosphere is linked to the evolution of <a title="Photosynthesis" href="http://en.wikipedia.org/wiki/Photosynthesis">photosynthesis</a>.The <a title="Proteome" href="http://en.wikipedia.org/wiki/Proteome">proteomic</a> evidence also supports the universal ancestry of life. Vital <a title="Protein" href="http://en.wikipedia.org/wiki/Protein">proteins</a>, such as the <a title="Ribosome" href="http://en.wikipedia.org/wiki/Ribosome">ribosome</a>, <a title="DNA polymerase" href="http://en.wikipedia.org/wiki/DNA_polymerase">DNA polymerase</a>, and <a title="RNA polymerase" href="http://en.wikipedia.org/wiki/RNA_polymerase">RNA polymerase</a>, are found in everything from the most primitive bacteria to the most complex mammals. The core part of the protein is conserved across all lineages of life, serving similar functions. Higher organisms have evolved additional <a title="Protein subunit" href="http://en.wikipedia.org/wiki/Protein_subunit">protein subunits</a>, largely affecting the regulation and <a title="Protein-protein interaction" href="http://en.wikipedia.org/wiki/Protein-protein_interaction">protein-protein interaction</a> of the core. Other overarching similarities between all lineages of extant organisms, such as <a title="DNA" href="http://en.wikipedia.org/wiki/DNA">DNA</a>, <a title="RNA" href="http://en.wikipedia.org/wiki/RNA">RNA</a>, <a title="Amino acid" href="http://en.wikipedia.org/wiki/Amino_acid">amino acids</a>, and the <a title="Lipid bilayer" href="http://en.wikipedia.org/wiki/Lipid_bilayer">lipid bilayer</a>, give support to the theory of common descent. The <a title="Chirality (chemistry)" href="http://en.wikipedia.org/wiki/Chirality_%28chemistry%29">chirality</a> of DNA, RNA, and amino acids is conserved across all known life. As there is no functional advantage to right- or left-handed molecular chirality, the simplest hypothesis is that the choice was made randomly by early organisms and passed on to all extant life through <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">common descent</a>. Further evidence for reconstructing ancestral lineages comes from <a title="Junk DNA" href="http://en.wikipedia.org/wiki/Junk_DNA">junk DNA</a> such as <a title="Pseudogene" href="http://en.wikipedia.org/wiki/Pseudogene">pseudogenes</a>, "dead" genes which steadily accumulate mutations.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-89">[107]</a>There is also a large body of molecular evidence for a number of different mechanisms for large evolutionary changes, among them: genome and <a title="Gene duplication" href="http://en.wikipedia.org/wiki/Gene_duplication">gene duplication</a>, which facilitates rapid evolution by providing substantial quantities of genetic material under weak or no selective constraints; <a title="Horizontal gene transfer" href="http://en.wikipedia.org/wiki/Horizontal_gene_transfer">horizontal gene transfer</a>, the process of transferring genetic material to another cell that is not an organism's offspring, allowing for species to acquire beneficial genes from each other; <a title="Genetic recombination" href="http://en.wikipedia.org/wiki/Genetic_recombination">recombination</a>, capable of reassorting large numbers of different alleles and of establishing <a title="Reproductive isolation" href="http://en.wikipedia.org/wiki/Reproductive_isolation">reproductive isolation</a>; and <a title="Endosymbiotic theory" href="http://en.wikipedia.org/wiki/Endosymbiotic_theory">endosymbiosis</a>, the incorporation of genetic material and biochemical composition of a separate species, a process observed in organisms such as the protist <a title="Hatena" href="http://en.wikipedia.org/wiki/Hatena">hatena</a> and used to explain the origin of <a title="Organelle" href="http://en.wikipedia.org/wiki/Organelle">organelles</a> such as <a title="Mitochondria" href="http://en.wikipedia.org/wiki/Mitochondria">mitochondria</a> and <a title="Plastid" href="http://en.wikipedia.org/wiki/Plastid">plastids</a> as the absorption of ancient <a title="Prokaryote" href="http://en.wikipedia.org/wiki/Prokaryote">prokaryotic</a> cells into ancient eukaryotic ones.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-90">[108]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-91">[109]</a> <h2>Evolutionary history of life</h2><div class="thumb tright"><div class="thumbinner" style="WIDTH: 352px"><a class="internal" title="A phylogenetic tree of all extant organisms, based on 16S rRNA gene sequence data, showing the evolutionary history of the three domains of life, bacteria, archaea and eukaryotes. Originally proposed by Carl Woese" href="http://en.wikipedia.org/wiki/Image:Phylogenetic_tree.svg"><img class="thumbimage" height="236" alt="A phylogenetic tree of all extant organisms, based on 16S rRNA gene sequence data, showing the evolutionary history of the three domains of life, bacteria, archaea and eukaryotes. Originally proposed by Carl Woese" width="350" longdesc="/wiki/Image:Phylogenetic_tree.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/7/70/Phylogenetic_tree.svg/350px-Phylogenetic_tree.svg.png" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Phylogenetic_tree.svg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>A <a title="Phylogenetic tree" href="http://en.wikipedia.org/wiki/Phylogenetic_tree">phylogenetic tree</a> of all extant organisms, based on 16S <a title="Non-coding RNA" href="http://en.wikipedia.org/wiki/Non-coding_RNA">rRNA</a> <a title="Gene" href="http://en.wikipedia.org/wiki/Gene">gene</a> sequence data, showing the evolutionary history of the <a title="Three-domain system" href="http://en.wikipedia.org/wiki/Three-domain_system">three domains of life</a>, <a title="Bacteria" href="http://en.wikipedia.org/wiki/Bacteria">bacteria</a>, <a title="Archaea" href="http://en.wikipedia.org/wiki/Archaea">archaea</a> and <a title="Eukaryote" href="http://en.wikipedia.org/wiki/Eukaryote">eukaryotes</a>. Originally proposed by <a title="Carl Woese" href="http://en.wikipedia.org/wiki/Carl_Woese">Carl Woese</a></div></div></div><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Timeline of evolution" href="http://en.wikipedia.org/wiki/Timeline_of_evolution">Timeline of evolution</a>. </dd></dl></div>Life must exist before it starts diversifying, and so the <a title="Origin of life" href="http://en.wikipedia.org/wiki/Origin_of_life">origin of life</a> is a necessary precursor for biological evolution.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-HowStuffWorks">[110]</a> How life came to exist is not relevant to evolution,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-92">[111]</a> and indeed <a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Darwin</a> wrote of "life, with its several powers, having been originally breathed by the Creator into a few forms or into one",<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-93">[112]</a> but the question of pre-evolutionary <a title="Abiogenesis" href="http://en.wikipedia.org/wiki/Abiogenesis">abiogenesis</a> is a subject of scientific study<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-94">[113]</a> which is often discussed under the general heading of evolution.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-HowStuffWorks">[110]</a> The current <a title="Scientific consensus" href="http://en.wikipedia.org/wiki/Scientific_consensus">scientific consensus</a> is that life began from <a title="Catalysis" href="http://en.wikipedia.org/wiki/Catalysis">self-catalytic</a> chemical reactions, but disputes over what defines <a title="Life" href="http://en.wikipedia.org/wiki/Life">life</a> make the point at which such increasingly complex sets of reactions became true organisms unclear. Not much is yet known about the earliest developments in life. There is no scientific consensus regarding the relationship of the three domains of organisms (<a title="Archaea" href="http://en.wikipedia.org/wiki/Archaea">Archaea</a>, <a title="Bacteria" href="http://en.wikipedia.org/wiki/Bacteria">Bacteria</a>, and <a title="Eukaryota" href="http://en.wikipedia.org/wiki/Eukaryota">Eukaryota</a>) or regarding the precise reactions involved in abiogenesis. Attempts to shed light on the origin of life generally focus on the behavior of <a title="Macromolecule" href="http://en.wikipedia.org/wiki/Macromolecule">macromolecules</a>—particularly <a title="RNA" href="http://en.wikipedia.org/wiki/RNA">RNA</a>—and the behavior of <a title="Complex system" href="http://en.wikipedia.org/wiki/Complex_system">complex systems</a>.Fossil evidence indicates that the diversity and complexity of modern life has developed over much of the <a title="Age of the Earth" href="http://en.wikipedia.org/wiki/Age_of_the_Earth">4.57 billion year</a> <a title="History of Earth" href="http://en.wikipedia.org/wiki/History_of_Earth">history of Earth</a>. Oxygenic <a title="Photosynthesis" href="http://en.wikipedia.org/wiki/Photosynthesis">photosynthesis</a> emerged around 3 billion years ago, and the subsequent emergence of an oxygen-rich atmosphere made the development of <a title="Aerobic respiration" href="http://en.wikipedia.org/wiki/Aerobic_respiration">aerobic</a> <a title="Cellular respiration" href="http://en.wikipedia.org/wiki/Cellular_respiration">cellular respiration</a> possible around 2 billion years ago. In the last billion years, simple multicellular plants and animals began to appear in the oceans. Soon after the emergence of the first animals, the <a title="Cambrian explosion" href="http://en.wikipedia.org/wiki/Cambrian_explosion">Cambrian explosion</a>, a geologically brief period of remarkable biological diversity, originated all the major body plans, or <a title="Phylum (biology)" href="http://en.wikipedia.org/wiki/Phylum_%28biology%29">phyla</a>, of modern animals. This event may have been triggered by the development of the <a title="Homeobox" href="http://en.wikipedia.org/wiki/Homeobox">Hox genes</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-95">[114]</a>About 500 million years ago (<a title="Mya (unit)" href="http://en.wikipedia.org/wiki/Mya_%28unit%29">mya</a>), <a title="Plant" href="http://en.wikipedia.org/wiki/Plant">plants</a> and <a title="Fungus" href="http://en.wikipedia.org/wiki/Fungus">fungi</a> colonized the land, and were soon followed by <a title="Arthropod" href="http://en.wikipedia.org/wiki/Arthropod">arthropods</a> and other animals. <a title="Amphibian" href="http://en.wikipedia.org/wiki/Amphibian">Amphibians</a> first appeared around 300 mya, followed by <a title="Reptile" href="http://en.wikipedia.org/wiki/Reptile">reptiles</a>, then <a title="Mammal" href="http://en.wikipedia.org/wiki/Mammal">mammals</a> around 200 mya and <a title="Bird" href="http://en.wikipedia.org/wiki/Bird">birds</a> around 100 mya. The <a title="Homo (genus)" href="http://en.wikipedia.org/wiki/Homo_%28genus%29">human genus</a> arose around 2 mya, while the earliest modern humans lived 200 thousand years ago. <h2>Social and religious controversies</h2><div class="thumb tright"><div class="thumbinner" style="WIDTH: 162px"><a class="internal" title="This caricature of Charles Darwin as an ape reflects the cultural backlash against evolution and common descent." href="http://en.wikipedia.org/wiki/Image:Darwin_ape.jpg"><img class="thumbimage" height="203" alt="This caricature of Charles Darwin as an ape reflects the cultural backlash against evolution and common descent." width="160" longdesc="/wiki/Image:Darwin_ape.jpg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Darwin_ape.jpg/160px-Darwin_ape.jpg" /></a><div class="thumbcaption"><div class="magnify" style="FLOAT: right"><a class="internal" title="Enlarge" href="http://en.wikipedia.org/wiki/Image:Darwin_ape.jpg"><img height="11" alt="" width="15" src="http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png" /></a></div>This caricature of <a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Charles Darwin</a> as an <a title="Ape" href="http://en.wikipedia.org/wiki/Ape">ape</a> reflects the cultural backlash against evolution and <a title="Common descent" href="http://en.wikipedia.org/wiki/Common_descent">common descent</a>.</div></div></div><div class="boilerplate seealso"><dl><dd>For more details on this topic, see <a title="Social effect of evolutionary theory" href="http://en.wikipedia.org/wiki/Social_effect_of_evolutionary_theory">Social effect of evolutionary theory</a>, <a title="Creation-evolution controversy" href="http://en.wikipedia.org/wiki/Creation-evolution_controversy">Creation-evolution controversy</a>, and <a title="Objections to evolution" href="http://en.wikipedia.org/wiki/Objections_to_evolution">Objections to evolution</a>. </dd></dl></div>Ever since the publication of <a title="The Origin of Species" href="http://en.wikipedia.org/wiki/The_Origin_of_Species">The Origin of Species</a> in 1859, evolution has been a source of controversy. In general, controversy has centered on the philosophical, social, and religious implications of evolution, not on the science of evolution itself; the proposition that biological evolution occurs through the mechanism of natural selection is completely uncontested within the <a title="Scientific community" href="http://en.wikipedia.org/wiki/Scientific_community">scientific community</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-96">[115]</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-97">[116]</a>As Darwin recognized early on, perhaps the most controversial aspect of evolutionary thought is <a title="Human evolution" href="http://en.wikipedia.org/wiki/Human_evolution">its applicability to human beings</a>. Specifically, many object to the idea that all diversity in life, including human beings, arose through <a title="Natural science" href="http://en.wikipedia.org/wiki/Natural_science">natural</a> processes without a need for supernatural intervention. Although many religions, such as <a title="Evolution and the Roman Catholic Church" href="http://en.wikipedia.org/wiki/Evolution_and_the_Roman_Catholic_Church">Catholicism</a>, have reconciled their beliefs with evolution through <a title="Theistic evolution" href="http://en.wikipedia.org/wiki/Theistic_evolution">theistic evolution</a>, <a title="Creationism" href="http://en.wikipedia.org/wiki/Creationism">creationists</a> <a title="Objections to evolution" href="http://en.wikipedia.org/wiki/Objections_to_evolution">object to evolution</a> on the basis that it contradicts their theistic <a title="Origin belief" href="http://en.wikipedia.org/wiki/Origin_belief">origin beliefs</a>.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-98">[117]</a> In some countries — notably the <a title="United States" href="http://en.wikipedia.org/wiki/United_States">United States</a> — these tensions between scientific and religious teachings have fueled the ongoing <a title="Creation-evolution controversy" href="http://en.wikipedia.org/wiki/Creation-evolution_controversy">creation-evolution controversy</a>, a social and religious conflict especially centering on <a title="Politics of creationism" href="http://en.wikipedia.org/wiki/Politics_of_creationism">politics</a> and <a title="Creation and evolution in public education" href="http://en.wikipedia.org/wiki/Creation_and_evolution_in_public_education">public education</a>. While other fields of science, such as <a title="Physical cosmology" href="http://en.wikipedia.org/wiki/Physical_cosmology">cosmology</a><a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-wmap">[118]</a> and <a title="Earth science" href="http://en.wikipedia.org/wiki/Earth_science">earth science</a>,<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-zircon">[119]</a> also conflict with literal interpretations of many religious texts, evolutionary biology has borne the brunt of these debates.Evolution has been used to support philosophical and ethical views which most contemporary scientists consider to have been neither mandated by evolution nor supported by science.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-99">[120]</a> For example, the <a title="Eugenics" href="http://en.wikipedia.org/wiki/Eugenics">eugenic</a> ideas of <a title="Francis Galton" href="http://en.wikipedia.org/wiki/Francis_Galton">Francis Galton</a> were developed into arguments that the human gene pool should be improved by <a title="Selective breeding" href="http://en.wikipedia.org/wiki/Selective_breeding">selective breeding</a> policies, including incentives for reproduction for those of "good stock" and disincentives, such as <a title="Compulsory sterilization" href="http://en.wikipedia.org/wiki/Compulsory_sterilization">compulsory sterilization</a>, <a title="T-4 Euthanasia Program" href="http://en.wikipedia.org/wiki/T-4_Euthanasia_Program">"euthanasia"</a>, and later, <a title="Prenatal testing" href="http://en.wikipedia.org/wiki/Prenatal_testing">prenatal testing</a>, <a title="Birth control" href="http://en.wikipedia.org/wiki/Birth_control">birth control</a>, and <a title="Genetic engineering" href="http://en.wikipedia.org/wiki/Genetic_engineering">genetic engineering</a>, for those of "bad stock". Another example of an extension of evolutionary theory that is now widely regarded as unwarranted is "<a title="Social Darwinism" href="http://en.wikipedia.org/wiki/Social_Darwinism">Social Darwinism</a>", a term given to the 19th century <a title="British Whig Party" href="http://en.wikipedia.org/wiki/British_Whig_Party">Whig</a> <a title="Malthusianism" href="http://en.wikipedia.org/wiki/Malthusianism">Malthusian</a> theory developed by <a title="Herbert Spencer" href="http://en.wikipedia.org/wiki/Herbert_Spencer">Herbert Spencer</a> into ideas about "<a title="Survival of the fittest" href="http://en.wikipedia.org/wiki/Survival_of_the_fittest">survival of the fittest</a>" in commerce and human societies as a whole, and by others into claims that <a title="Social inequality" href="http://en.wikipedia.org/wiki/Social_inequality">social inequality</a>, <a title="Racism" href="http://en.wikipedia.org/wiki/Racism">racism</a>, and <a title="Imperialism" href="http://en.wikipedia.org/wiki/Imperialism">imperialism</a> were justified.<a title="" href="http://en.wikipedia.org/wiki/Evolution#_note-100">[121]</a>  <h2>References</h2><div class="references-small" style="-moz-column-count: 2; column-count: 2"><ol class="references"> <li id="_note-Futuyma">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Futuyma_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Futuyma_1">b</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Futuyma_2">c</a> <cite class="book" id="Reference-Futuyma-2005" style="FONT-STYLE: normal"><a title="Douglas J. Futuyma" href="http://en.wikipedia.org/wiki/Douglas_J._Futuyma">Futuyma, Douglas J.</a> (2005). Evolution. <a title="Sunderland, Massachusetts" href="http://en.wikipedia.org/wiki/Sunderland%2C_Massachusetts">Sunderland</a>, <a title="Massachusetts" href="http://en.wikipedia.org/wiki/Massachusetts">Massachusetts</a>: Sinauer Associates, Inc. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0878931872">ISBN 0-87893-187-2</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Evolution&rft.aulast=Futuyma&rft.aufirst=Douglas+J.&rft.date=2005&rft.pub=Sinauer+Associates%2C+Inc&rft.place=%5B%5BSunderland%2C+Massachusetts%7CSunderland%5D%5D%2C+%5B%5BMassachusetts%5D%5D">  </li> <li id="_note-0"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-0">^</a> <cite style="FONT-STYLE: normal">Lande, R.; Arnold, S.J. (1983). "The measurement of selection on correlated characters". <a title="Evolution (journal)" href="http://en.wikipedia.org/wiki/Evolution_%28journal%29">Evolution</a> 37: 1210–1226.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+measurement+of+selection+on+correlated+characters&rft.jtitle=%5B%5BEvolution+%28journal%29%7CEvolution%5D%5D&rft.date=1983&rft.volume=37&rft.au=Lande%2C+R.&rft.pages=1210%26ndash%3B1226">  </li> <li id="_note-1"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-1">^</a> <cite style="FONT-STYLE: normal">Haldane, J.B.S. (1953). "The measurement of natural selection". Proceedings of the 9th International Congress of Genetics 1: 480–487.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+measurement+of+natural+selection&rft.jtitle=Proceedings+of+the+9th+International+Congress+of+Genetics&rft.date=1953&rft.volume=1&rft.au=Haldane%2C+J.B.S.&rft.pages=480%26ndash%3B487">  </li> <li id="_note-understandingevolution">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-understandingevolution_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-understandingevolution_1">b</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-understandingevolution_2">c</a> <a class="external text" title="http://evolution.berkeley.edu/evolibrary/article/0_0_0/evo_14" rel="nofollow" href="http://evolution.berkeley.edu/evolibrary/article/0_0_0/evo_14">Mechanisms: the processes of evolution</a>. Understanding Evolution. <a title="University of California, Berkeley" href="http://en.wikipedia.org/wiki/University_of_California%2C_Berkeley">University of California, Berkeley</a>. Retrieved on <a title="2006" href="http://en.wikipedia.org/wiki/2006">2006</a>-<a title="July 14" href="http://en.wikipedia.org/wiki/July_14">07-14</a>. </li> <li id="_note-2"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-2">^</a> <cite class="book" id="Reference-Gould-2002" style="FONT-STYLE: normal"><a title="Stephen Gould" href="http://en.wikipedia.org/wiki/Stephen_Gould">Gould, Stephen J.</a> (2002). The Structure of Evolutionary Theory. Belknap Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0674006135">ISBN 0-674-00613-5</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Structure+of+Evolutionary+Theory&rft.aulast=Gould&rft.aufirst=Stephen+J.&rft.date=2002&rft.pub=Belknap+Press">  </li> <li id="_note-3"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-3">^</a> <cite class="book" id="Reference-Dawkins-1989" style="FONT-STYLE: normal"><a title="Richard Dawkins" href="http://en.wikipedia.org/wiki/Richard_Dawkins">Dawkins, Richard</a> (1989). The Selfish Gene. Oxford University Press Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0674006135">ISBN 0-674-00613-5</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Selfish+Gene&rft.aulast=Dawkins&rft.aufirst=Richard&rft.date=1989&rft.pub=Oxford+University+Press+Press">  </li> <li id="_note-4"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-4">^</a> <a class="external text" title="http://www.interacademies.net/Object.File/Master/6/150/Evolution%20statement.pdf" rel="nofollow" href="http://www.interacademies.net/Object.File/Master/6/150/Evolution%20statement.pdf">IAP Statement on the Teaching of Evolution</a>. The Interacademy Panel on International Issues (2006). Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="April 25" href="http://en.wikipedia.org/wiki/April_25">04-25</a>. </li> <li id="_note-5"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-5">^</a> <a class="external text" title="http://www.aaas.org/news/releases/2006/pdf/0219boardstatement.pdf" rel="nofollow" href="http://www.aaas.org/news/releases/2006/pdf/0219boardstatement.pdf">Statement on the Teaching of Evolution</a>. American Association for the Advancement of Science (2006). Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="April 25" href="http://en.wikipedia.org/wiki/April_25">04-25</a>. </li> <li id="_note-6"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-6">^</a> Pinholster, G (2006). <a class="external text" title="http://www.aaas.org/news/releases/2006/0219boardstatement.shtml" rel="nofollow" href="http://www.aaas.org/news/releases/2006/0219boardstatement.shtml">AAAS Denounces Anti-Evolution Laws as Hundreds of K-12 Teachers Convene for 'Front Line' Event</a>. American Association for the Advancement of Science. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="April 25" href="http://en.wikipedia.org/wiki/April_25">04-25</a>. </li> <li id="_note-Osborn">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Osborn_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Osborn_1">b</a> Henry Fairfield Osborn (1905) <a class="external text" title="http://books.google.com/books?hl=en&lr=&id=ONYKAAAAIAAJ&oi=fnd&pg=PA1&dq=Anaximander+evolution&ots=MoN3ulgt7d&sig=wH4z8dMx7pynWdh2q3_mezgMUKM" rel="nofollow" href="http://books.google.com/books?hl=en&lr=&id=ONYKAAAAIAAJ&oi=fnd&pg=PA1&dq=Anaximander+evolution&ots=MoN3ulgt7d&sig=wH4z8dMx7pynWdh2q3_mezgMUKM">From the Greeks to Darwin: An Outline of the Development of the Evolution Idea</a> Macmillan and Co. </li> <li id="_note-7"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-7">^</a> <cite style="FONT-STYLE: normal">Stafleu F (1971). "Lamarck: The birth of biology". Taxon 20: 397-442. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11636092" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11636092">PMID 11636092</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lamarck%3A+The+birth+of+biology&rft.jtitle=Taxon&rft.date=1971&rft.volume=20&rft.au=Stafleu+F&rft.pages=397-442&rft_id=info:pmid/11636092">  </li> <li id="_note-8"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-8">^</a> Wallace A and Darwin C., <a class="external text" title="http://darwin-online.org.uk/content/frameset?itemID=F350&viewtype=text&pageseq=1" rel="nofollow" href="http://darwin-online.org.uk/content/frameset?itemID=F350&viewtype=text&pageseq=1">"On the Tendency of Species to form Varieties, and on the Perpetuation of Varieties and Species by Natural Means of Selection,"</a> Jour. of the Proc. of the Linnean Society (Zoology), 3 (July 1858): 53-62 </li> <li id="_note-Weiling">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Weiling_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Weiling_1">b</a> <cite style="FONT-STYLE: normal">Weiling F (1991). "Historical study: Johann Gregor Mendel 1822-1884". Am. J. Med. Genet. 40 (1): 1-25; discussion 26. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1887835" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1887835">PMID 1887835</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Historical+study%3A+Johann+Gregor+Mendel+1822-1884&rft.jtitle=Am.+J.+Med.+Genet.&rft.date=1991&rft.volume=40&rft.issue=1&rft.au=Weiling+F&rft.pages=1-25%3B+discussion+26&rft_id=info:pmid/1887835">  </li> <li id="_note-9"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-9">^</a> <cite class="book" id="Reference-Bowler-1989" style="FONT-STYLE: normal"><a title="Peter J. Bowler" href="http://en.wikipedia.org/wiki/Peter_J._Bowler">Bowler, Peter J.</a> (1989). The Mendelian Revolution: The Emergence of Hereditarian Concepts in Modern Science and Society. Baltimore: Johns Hopkins University Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780801838880">ISBN 978-0801838880</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Mendelian+Revolution%3A+The+Emergence+of+Hereditarian+Concepts+in+Modern+Science+and+Society&rft.aulast=Bowler&rft.aufirst=Peter+J.&rft.date=1989&rft.pub=Johns+Hopkins+University+Press&rft.place=Baltimore&rft.isbn=978-0801838880">  </li> <li id="_note-10"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-10">^</a> <cite style="FONT-STYLE: normal">Avery O, MacLeod C, McCarty M (1944). "<a class="external text" title="http://www.jem.org/cgi/reprint/149/2/297" rel="nofollow" href="http://www.jem.org/cgi/reprint/149/2/297">Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III</a>". J Exp Med 79 (2): 137 – 158.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Studies+on+the+chemical+nature+of+the+substance+inducing+transformation+of+pneumococcal+types.+Inductions+of+transformation+by+a+desoxyribonucleic+acid+fraction+isolated+from+pneumococcus+type+III&rft.jtitle=J+Exp+Med&rft.date=1944&rft.volume=79&rft.issue=2&rft.au=Avery+O%2C+MacLeod+C%2C+McCarty+M&rft.pages=137+%E2%80%93+158&rft_id=http%3A%2F%2Fwww.jem.org%2Fcgi%2Freprint%2F149%2F2%2F297">  </li> <li id="_note-Watson"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Watson_0">^</a> <cite style="FONT-STYLE: normal">Watson J, Crick F (1953). "<a class="external text" title="http://profiles.nlm.nih.gov/SC/B/B/Y/W/_/scbbyw.pdf" rel="nofollow" href="http://profiles.nlm.nih.gov/SC/B/B/Y/W/_/scbbyw.pdf">Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid</a>". Nature 171 (4356): 737 – 8. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13054692" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13054692">PMID 13054692</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+structure+of+nucleic+acids%3B+a+structure+for+deoxyribose+nucleic+acid&rft.jtitle=Nature&rft.date=1953&rft.volume=171&rft.issue=4356&rft.au=Watson+J%2C+Crick+F&rft.pages=737+%E2%80%93+8&rft_id=http%3A%2F%2Fprofiles.nlm.nih.gov%2FSC%2FB%2FB%2FY%2FW%2F_%2Fscbbyw.pdf">  </li> <li id="_note-11"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-11">^</a> <cite style="FONT-STYLE: normal">Kutschera U, Niklas K (2004). "The modern theory of biological evolution: an expanded synthesis". Naturwissenschaften 91 (6): 255-76. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15241603" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15241603">PMID 15241603</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+modern+theory+of+biological+evolution%3A+an+expanded+synthesis&rft.jtitle=Naturwissenschaften&rft.date=2004&rft.volume=91&rft.issue=6&rft.au=Kutschera+U%2C+Niklas+K&rft.pages=255-76&rft_id=info:pmid/15241603">  </li> <li id="_note-12"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-12">^</a> <cite style="FONT-STYLE: normal">Edwards K, Brown D, Spink N, Skelly J, Neidle S (1992). "Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution". J. Mol. Biol. 226 (4): 1161-73. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1518049" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1518049">PMID 1518049</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+structure+of+the+B-DNA+dodecamer+d%28CGCAAATTTGCG%292.+An+examination+of+propeller+twist+and+minor-groove+water+structure+at+2.2+A+resolution&rft.jtitle=J.+Mol.+Biol.&rft.date=1992&rft.volume=226&rft.issue=4&rft.au=Edwards+K%2C+Brown+D%2C+Spink+N%2C+Skelly+J%2C+Neidle+S&rft.pages=1161-73&rft_id=info:pmid/1518049">  </li> <li id="_note-Pearson_2006">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Pearson_2006_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Pearson_2006_1">b</a> <cite style="FONT-STYLE: normal">Pearson H (2006). "Genetics: what is a gene?". Nature 441 (7092): 398-401. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16724031" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16724031">PMID 16724031</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetics%3A+what+is+a+gene%3F&rft.jtitle=Nature&rft.date=2006&rft.volume=441&rft.issue=7092&rft.au=Pearson+H&rft.pages=398-401&rft_id=info:pmid/16724031">  </li> <li id="_note-13"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-13">^</a> <cite style="FONT-STYLE: normal">Mayeux R (2005). "Mapping the new frontier: complex genetic disorders". J. Clin. Invest. 115 (6): 1404-7. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15931374" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15931374">PMID 15931374</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mapping+the+new+frontier%3A+complex+genetic+disorders&rft.jtitle=J.+Clin.+Invest.&rft.date=2005&rft.volume=115&rft.issue=6&rft.au=Mayeux+R&rft.pages=1404-7&rft_id=info:pmid/15931374">  </li> <li id="_note-Lin">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Lin_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Lin_1">b</a> <cite style="FONT-STYLE: normal">Wu R, Lin M (2006). "Functional mapping - how to map and study the genetic architecture of dynamic complex traits". Nat. Rev. Genet. 7 (3): 229-37. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16485021" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16485021">PMID 16485021</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+mapping+-+how+to+map+and+study+the+genetic+architecture+of+dynamic+complex+traits&rft.jtitle=Nat.+Rev.+Genet.&rft.date=2006&rft.volume=7&rft.issue=3&rft.au=Wu+R%2C+Lin+M&rft.pages=229-37&rft_id=info:pmid/16485021">  </li> <li id="_note-14"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-14">^</a> <cite style="FONT-STYLE: normal">Bernstein B, Meissner A, Lander E (2007). "The mammalian epigenome". Cell 128 (4): 669-81. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17320505" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17320505">PMID 17320505</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+mammalian+epigenome&rft.jtitle=Cell&rft.date=2007&rft.volume=128&rft.issue=4&rft.au=Bernstein+B%2C+Meissner+A%2C+Lander+E&rft.pages=669-81&rft_id=info:pmid/17320505">  </li> <li id="_note-15"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-15">^</a> <cite style="FONT-STYLE: normal">Wickner R, Edskes H, Ross E, Pierce M, Baxa U, Brachmann A, Shewmaker F (2004). "Prion genetics: new rules for a new kind of gene". Annu. Rev. Genet. 38: 681-707. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15355224" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15355224">PMID 15355224</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prion+genetics%3A+new+rules+for+a+new+kind+of+gene&rft.jtitle=Annu.+Rev.+Genet.&rft.date=2004&rft.volume=38&rft.au=Wickner+R%2C+Edskes+H%2C+Ross+E%2C+Pierce+M%2C+Baxa+U%2C+Brachmann+A%2C+Shewmaker+F&rft.pages=681-707&rft_id=info:pmid/15355224">  </li> <li id="_note-16"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-16">^</a> <cite style="FONT-STYLE: normal">Beisson, J (1965). "Cytoplasmic inheritance of the organization of the cell cortex of Paramecium aurelia". Proceedings of the National Academy of Sciences USA 53: 275-282.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytoplasmic+inheritance+of+the+organization+of+the+cell+cortex+of+Paramecium+aurelia&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+USA&rft.date=1965&rft.volume=53&rft.aulast=Beisson&rft.aufirst=J&rft.pages=275-282">  </li> <li id="_note-17"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-17">^</a> <cite style="FONT-STYLE: normal">Nelsen E, Frankel J, Jenkins L (1989). "Non-genic inheritance of cellular handedness". Development 105 (3): 447-56. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2612360" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2612360">PMID 2612360</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Non-genic+inheritance+of+cellular+handedness&rft.jtitle=Development&rft.date=1989&rft.volume=105&rft.issue=3&rft.au=Nelsen+E%2C+Frankel+J%2C+Jenkins+L&rft.pages=447-56&rft_id=info:pmid/2612360">  </li> <li id="_note-18"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-18">^</a> <cite style="FONT-STYLE: normal">Shorter J, Lindquist S (2005). "Prions as adaptive conduits of memory and inheritance". Nat. Rev. Genet. 6 (6): 435-50. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15931169" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15931169">PMID 15931169</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prions+as+adaptive+conduits+of+memory+and+inheritance&rft.jtitle=Nat.+Rev.+Genet.&rft.date=2005&rft.volume=6&rft.issue=6&rft.au=Shorter+J%2C+Lindquist+S&rft.pages=435-50&rft_id=info:pmid/15931169">  </li> <li id="_note-19"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-19">^</a> <cite style="FONT-STYLE: normal">Chien P, Weissman J, DePace A (2004). "Emerging principles of conformation-based prion inheritance". Annu. Rev. Biochem. 73: 617-56. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15189155" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15189155">PMID 15189155</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Emerging+principles+of+conformation-based+prion+inheritance&rft.jtitle=Annu.+Rev.+Biochem.&rft.date=2004&rft.volume=73&rft.au=Chien+P%2C+Weissman+J%2C+DePace+A&rft.pages=617-56&rft_id=info:pmid/15189155">  </li> <li id="_note-20"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-20">^</a> <cite style="FONT-STYLE: normal">Draghi J, Turner P (2006). "DNA secretion and gene-level selection in bacteria". Microbiology (Reading, Engl.) 152 (Pt 9): 2683-8. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16946263" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16946263">PMID 16946263</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DNA+secretion+and+gene-level+selection+in+bacteria&rft.jtitle=Microbiology+%28Reading%2C+Engl.%29&rft.date=2006&rft.volume=152&rft.issue=Pt+9&rft.au=Draghi+J%2C+Turner+P&rft.pages=2683-8&rft_id=info:pmid/16946263">  </li> <li id="_note-21"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-21">^</a> <cite style="FONT-STYLE: normal">Mallet J (2007). "Hybrid speciation". Nature 446 (7133): 279-83. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17361174" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17361174">PMID 17361174</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hybrid+speciation&rft.jtitle=Nature&rft.date=2007&rft.volume=446&rft.issue=7133&rft.au=Mallet+J&rft.pages=279-83&rft_id=info:pmid/17361174"> , </li> <li id="_note-22"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-22">^</a> <cite style="FONT-STYLE: normal">Butlin R, Tregenza T (1998). "<a class="external text" title="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1692210&blobtype=pdf" rel="nofollow" href="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1692210&blobtype=pdf">Levels of genetic polymorphism: marker loci versus quantitative traits</a>". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 353 (1366): 187-98. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9533123" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9533123">PMID 9533123</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Levels+of+genetic+polymorphism%3A+marker+loci+versus+quantitative+traits&rft.jtitle=Philos.+Trans.+R.+Soc.+Lond.%2C+B%2C+Biol.+Sci.&rft.date=1998&rft.volume=353&rft.issue=1366&rft.au=Butlin+R%2C+Tregenza+T&rft.pages=187-98&rft_id=info:pmid/9533123&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Fpicrender.fcgi%3Fartid%3D1692210%26blobtype%3Dpdf">  </li> <li id="_note-23"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-23">^</a> <cite style="FONT-STYLE: normal">Wetterbom A, Sevov M, Cavelier L, Bergström T (2006). "Comparative genomic analysis of human and chimpanzee indicates a key role for indels in primate evolution". J. Mol. Evol. 63 (5): 682-90. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17075697" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17075697">PMID 17075697</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparative+genomic+analysis+of+human+and+chimpanzee+indicates+a+key+role+for+indels+in+primate+evolution&rft.jtitle=J.+Mol.+Evol.&rft.date=2006&rft.volume=63&rft.issue=5&rft.au=Wetterbom+A%2C+Sevov+M%2C+Cavelier+L%2C+Bergstr%C3%B6m+T&rft.pages=682-90&rft_id=info:pmid/17075697">  </li> <li id="_note-24"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-24">^</a> <cite style="FONT-STYLE: normal">Stoltzfus A (2006). "Mutationism and the dual causation of evolutionary change". Evol. Dev. 8 (3): 304-17. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16686641" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16686641">PMID 16686641</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutationism+and+the+dual+causation+of+evolutionary+change&rft.jtitle=Evol.+Dev.&rft.date=2006&rft.volume=8&rft.issue=3&rft.au=Stoltzfus+A&rft.pages=304-17&rft_id=info:pmid/16686641">  </li> <li id="_note-Amos">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Amos_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Amos_1">b</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Amos_2">c</a> <cite style="FONT-STYLE: normal">Amos W, Harwood J (1998). "<a class="external text" title="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1692205&blobtype=pdf" rel="nofollow" href="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1692205&blobtype=pdf">Factors affecting levels of genetic diversity in natural populations</a>". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 353 (1366): 177-86. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9533122" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9533122">PMID 9533122</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Factors+affecting+levels+of+genetic+diversity+in+natural+populations&rft.jtitle=Philos.+Trans.+R.+Soc.+Lond.%2C+B%2C+Biol.+Sci.&rft.date=1998&rft.volume=353&rft.issue=1366&rft.au=Amos+W%2C+Harwood+J&rft.pages=177-86&rft_id=info:pmid/9533122&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Fpicrender.fcgi%3Fartid%3D1692205%26blobtype%3Dpdf">  </li> <li id="_note-Bertram">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Bertram_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Bertram_1">b</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Bertram_2">c</a> <cite style="FONT-STYLE: normal">Bertram J (2000). "The molecular biology of cancer". Mol. Aspects Med. 21 (6): 167-223. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11173079" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11173079">PMID 11173079</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+molecular+biology+of+cancer&rft.jtitle=Mol.+Aspects+Med.&rft.date=2000&rft.volume=21&rft.issue=6&rft.au=Bertram+J&rft.pages=167-223&rft_id=info:pmid/11173079">  </li> <li id="_note-25"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-25">^</a> <cite style="FONT-STYLE: normal">Aminetzach, YT; Macpherson JM and Petrov DA (1992). "Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila". Science 309 (5735): 764-7.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pesticide+resistance+via+transposition-mediated+adaptive+gene+truncation+in+Drosophila&rft.jtitle=Science&rft.date=1992&rft.volume=309&rft.issue=5735&rft.aulast=Aminetzach&rft.aufirst=YT&rft.pages=764-7">  </li> <li id="_note-Burrus"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Burrus_0">^</a> <cite style="FONT-STYLE: normal">Burrus V, Waldor M (2004). "Shaping bacterial genomes with integrative and conjugative elements". Res. Microbiol. 155 (5): 376-86. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15207870" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15207870">PMID 15207870</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Shaping+bacterial+genomes+with+integrative+and+conjugative+elements&rft.jtitle=Res.+Microbiol.&rft.date=2004&rft.volume=155&rft.issue=5&rft.au=Burrus+V%2C+Waldor+M&rft.pages=376-86&rft_id=info:pmid/15207870">  </li> <li id="_note-Sniegowski"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Sniegowski_0">^</a> <cite style="FONT-STYLE: normal">Sniegowski P, Gerrish P, Johnson T, Shaver A (2000). "The evolution of mutation rates: separating causes from consequences". Bioessays 22 (12): 1057-66. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11084621" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11084621">PMID 11084621</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+evolution+of+mutation+rates%3A+separating+causes+from+consequences&rft.jtitle=Bioessays&rft.date=2000&rft.volume=22&rft.issue=12&rft.au=Sniegowski+P%2C+Gerrish+P%2C+Johnson+T%2C+Shaver+A&rft.pages=1057-66&rft_id=info:pmid/11084621">  </li> <li id="_note-26"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-26">^</a> <cite style="FONT-STYLE: normal">Wright B (2004). "Stress-directed adaptive mutations and evolution". Mol. Microbiol. 52 (3): 643-50. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15101972" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15101972">PMID 15101972</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stress-directed+adaptive+mutations+and+evolution&rft.jtitle=Mol.+Microbiol.&rft.date=2004&rft.volume=52&rft.issue=3&rft.au=Wright+B&rft.pages=643-50&rft_id=info:pmid/15101972">  </li> <li id="_note-27"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-27">^</a> <cite class="book" style="FONT-STYLE: normal">Snustad, P; Simmons, A (2002). Principles of Genetics, 3rd edition. John Wiley and Sons, Inc, 20. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780471441809">ISBN 978-0471441809</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Principles+of+Genetics%2C+3rd+edition&rft.aulast=Snustad&rft.aufirst=P&rft.date=2002&rft.pub=John+Wiley+and+Sons%2C+Inc&rft.pages=20&rft.isbn=978-0471441809">  </li> <li id="_note-28"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-28">^</a> <cite class="book" style="FONT-STYLE: normal">Carroll S.B,. Grenier J.K., Weatherbee S.D. (2005). From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design. Second Edition. Oxford: Blackwell Publishing. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=1405119500">ISBN 1-4051-1950-0</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=From+DNA+to+Diversity%3A+Molecular+Genetics+and+the+Evolution+of+Animal+Design.+Second+Edition&rft.aulast=Carroll+S.B%2C.+Grenier+J.K.%2C+Weatherbee+S.D.&rft.date=2005&rft.pub=Blackwell+Publishing&rft.place=Oxford">  </li> <li id="_note-29"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-29">^</a> <cite style="FONT-STYLE: normal">Harrison P, Gerstein M (2002). "Studying genomes through the aeons: protein families, pseudogenes and proteome evolution". J Mol Biol 318 (5): 1155 – 74. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12083509" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12083509">PMID 12083509</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Studying+genomes+through+the+aeons%3A+protein+families%2C+pseudogenes+and+proteome+evolution&rft.jtitle=J+Mol+Biol&rft.date=2002&rft.volume=318&rft.issue=5&rft.au=Harrison+P%2C+Gerstein+M&rft.pages=1155+%E2%80%93+74">  </li> <li id="_note-30"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-30">^</a> <cite style="FONT-STYLE: normal">Orengo CA, Thornton JM (2005). "Protein families and their evolution-a structural perspective". Annu. Rev. Biochem. 74: 867-900. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15954844" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15954844">PMID 15954844</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protein+families+and+their+evolution-a+structural+perspective&rft.jtitle=Annu.+Rev.+Biochem.&rft.date=2005&rft.volume=74&rft.au=Orengo+CA%2C+Thornton+JM&rft.pages=867-900&rft_id=info:pmid/15954844">  </li> <li id="_note-31"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-31">^</a> <cite style="FONT-STYLE: normal">Pál C, Papp B, Lercher MJ (2006). "An integrated view of protein evolution". Nat. Rev. Genet. 7 (5): 337-48. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16619049" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16619049">PMID 16619049</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+integrated+view+of+protein+evolution&rft.jtitle=Nat.+Rev.+Genet.&rft.date=2006&rft.volume=7&rft.issue=5&rft.au=P%C3%A1l+C%2C+Papp+B%2C+Lercher+MJ&rft.pages=337-48&rft_id=info:pmid/16619049">  </li> <li id="_note-Wendel">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Wendel_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Wendel_1">b</a> <cite style="FONT-STYLE: normal">Wendel J (2000). "Genome evolution in polyploids". Plant Mol. Biol. 42 (1): 225-49. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10688139" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10688139">PMID 10688139</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome+evolution+in+polyploids&rft.jtitle=Plant+Mol.+Biol.&rft.date=2000&rft.volume=42&rft.issue=1&rft.au=Wendel+J&rft.pages=225-49&rft_id=info:pmid/10688139">  </li> <li id="_note-32"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-32">^</a> <cite style="FONT-STYLE: normal">Rieseberg (2001). "Chromosomal rearrangements and speciation" 16 (7): 351-358. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11403867" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11403867">PMID 11403867</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chromosomal+rearrangements+and+speciation&rft.date=2001&rft.volume=16&rft.issue=7&rft.au=Rieseberg&rft.pages=351-358&rft_id=info:pmid/11403867">  </li> <li id="_note-33"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-33">^</a> <cite style="FONT-STYLE: normal">(2005) "Initial sequence of the chimpanzee genome and comparison with the human genome". Nature 437 (7055): 69-87. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16136131" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16136131">PMID 16136131</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Initial+sequence+of+the+chimpanzee+genome+and+comparison+with+the+human+genome&rft.jtitle=Nature&rft.date=2005&rft.volume=437&rft.issue=7055&rft.pages=69-87&rft_id=info:pmid/16136131">  </li> <li id="_note-34"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-34">^</a> <cite style="FONT-STYLE: normal">Zhang J, Wang X, Podlaha O (2004). "<a class="external text" title="http://www.genome.org/cgi/content/full/14/5/845" rel="nofollow" href="http://www.genome.org/cgi/content/full/14/5/845">Testing the chromosomal speciation hypothesis for humans and chimpanzees</a>". Genome Res. 14 (5): 845-51. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15123584" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15123584">PMID 15123584</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Testing+the+chromosomal+speciation+hypothesis+for+humans+and+chimpanzees&rft.jtitle=Genome+Res.&rft.date=2004&rft.volume=14&rft.issue=5&rft.au=Zhang+J%2C+Wang+X%2C+Podlaha+O&rft.pages=845-51&rft_id=info:pmid/15123584&rft_id=http%3A%2F%2Fwww.genome.org%2Fcgi%2Fcontent%2Ffull%2F14%2F5%2F845">  </li> <li id="_note-35"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-35">^</a> <cite style="FONT-STYLE: normal">Radding C (1982). "Homologous pairing and strand exchange in genetic recombination". Annu. Rev. Genet. 16: 405-37. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6297377" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6297377">PMID 6297377</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Homologous+pairing+and+strand+exchange+in+genetic+recombination&rft.jtitle=Annu.+Rev.+Genet.&rft.date=1982&rft.volume=16&rft.au=Radding+C&rft.pages=405-37&rft_id=info:pmid/6297377">  </li> <li id="_note-36"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-36">^</a> <cite style="FONT-STYLE: normal">Lien S, Szyda J, Schechinger B, Rappold G, Arnheim N (2000). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10677316" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10677316">Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping</a>". Am. J. Hum. Genet. 66 (2): 557-66. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10677316" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10677316">PMID 10677316</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evidence+for+heterogeneity+in+recombination+in+the+human+pseudoautosomal+region%3A+high+resolution+analysis+by+sperm+typing+and+radiation-hybrid+mapping&rft.jtitle=Am.+J.+Hum.+Genet.&rft.date=2000&rft.volume=66&rft.issue=2&rft.au=Lien+S%2C+Szyda+J%2C+Schechinger+B%2C+Rappold+G%2C+Arnheim+N&rft.pages=557-66&rft_id=info:pmid/10677316&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D10677316">  </li> <li id="_note-37"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-37">^</a> <cite style="FONT-STYLE: normal">Sabeti P, Schaffner S, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen T, Altshuler D, Lander E (2006). "Positive natural selection in the human lineage". Science 312 (5780): 1614-20. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16778047" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16778047">PMID 16778047</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Positive+natural+selection+in+the+human+lineage&rft.jtitle=Science&rft.date=2006&rft.volume=312&rft.issue=5780&rft.au=Sabeti+P%2C+Schaffner+S%2C+Fry+B%2C+Lohmueller+J%2C+Varilly+P%2C+Shamovsky+O%2C+Palma+A%2C+Mikkelsen+T%2C+Altshuler+D%2C+Lander+E&rft.pages=1614-20&rft_id=info:pmid/16778047">  </li> <li id="_note-Otto">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Otto_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Otto_1">b</a> <cite style="FONT-STYLE: normal">Otto S (2003). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12871918" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12871918">The advantages of segregation and the evolution of sex</a>". Genetics 164 (3): 1099-118. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12871918" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12871918">PMID 12871918</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+advantages+of+segregation+and+the+evolution+of+sex&rft.jtitle=Genetics&rft.date=2003&rft.volume=164&rft.issue=3&rft.au=Otto+S&rft.pages=1099-118&rft_id=info:pmid/12871918&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D12871918">  </li> <li id="_note-38"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-38">^</a> <cite style="FONT-STYLE: normal">Charlesworth B, Charlesworth D (2000). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11127901" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11127901">The degeneration of Y chromosomes</a>". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1403): 1563-72. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11127901" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11127901">PMID 11127901</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+degeneration+of+Y+chromosomes&rft.jtitle=Philos.+Trans.+R.+Soc.+Lond.%2C+B%2C+Biol.+Sci.&rft.date=2000&rft.volume=355&rft.issue=1403&rft.au=Charlesworth+B%2C+Charlesworth+D&rft.pages=1563-72&rft_id=info:pmid/11127901&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D11127901">  </li> <li id="_note-39"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-39">^</a> <cite style="FONT-STYLE: normal">Hill W, Robertson A (1966). "The effect of linkage on limits to artificial selection". Genet. Res. 8 (3): 269-94. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=5980116" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=5980116">PMID 5980116</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+linkage+on+limits+to+artificial+selection&rft.jtitle=Genet.+Res.&rft.date=1966&rft.volume=8&rft.issue=3&rft.au=Hill+W%2C+Robertson+A&rft.pages=269-94&rft_id=info:pmid/5980116">  </li> <li id="_note-40"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-40">^</a> <cite style="FONT-STYLE: normal">Muller H (1964). "The relation of recombination to mutational advance". Mutat. Res. 106: 2-9. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14195748" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14195748">PMID 14195748</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+relation+of+recombination+to+mutational+advance&rft.jtitle=Mutat.+Res.&rft.date=1964&rft.volume=106&rft.au=Muller+H&rft.pages=2-9&rft_id=info:pmid/14195748">  </li> <li id="_note-41"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-41">^</a> <cite style="FONT-STYLE: normal">Morjan C, Rieseberg L (2004). "How species evolve collectively: implications of gene flow and selection for the spread of advantageous alleles". Mol. Ecol. 13 (6): 1341-56. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15140081" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15140081">PMID 15140081</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=How+species+evolve+collectively%3A+implications+of+gene+flow+and+selection+for+the+spread+of+advantageous+alleles&rft.jtitle=Mol.+Ecol.&rft.date=2004&rft.volume=13&rft.issue=6&rft.au=Morjan+C%2C+Rieseberg+L&rft.pages=1341-56&rft_id=info:pmid/15140081">  </li> <li id="_note-42"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-42">^</a> <cite style="FONT-STYLE: normal">Su H, Qu L, He K, Zhang Z, Wang J, Chen Z, Gu H (2003). "The Great Wall of China: a physical barrier to gene flow?". Heredity 90 (3): 212-9. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12634804" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12634804">PMID 12634804</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Great+Wall+of+China%3A+a+physical+barrier+to+gene+flow%3F&rft.jtitle=Heredity&rft.date=2003&rft.volume=90&rft.issue=3&rft.au=Su+H%2C+Qu+L%2C+He+K%2C+Zhang+Z%2C+Wang+J%2C+Chen+Z%2C+Gu+H&rft.pages=212-9&rft_id=info:pmid/12634804">  </li> <li id="_note-43"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-43">^</a> Duttaroy, Asim K (2006). <a class="external text" title="http://www.mukto-mona.com/Special_Event_/Darwin_day/evolution_asim120206.htm" rel="nofollow" href="http://www.mukto-mona.com/Special_Event_/Darwin_day/evolution_asim120206.htm">Evolution, epigenetics, and maternal nutrition</a>. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 16" href="http://en.wikipedia.org/wiki/March_16">03-16</a>. </li> <li id="_note-44"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-44">^</a> <cite style="FONT-STYLE: normal">Nosil P, Crespi B, Gries R, Gries G (2007). "Natural selection and divergence in mate preference during speciation". Genetica 129 (3): 309-27. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16900317" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16900317">PMID 16900317</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Natural+selection+and+divergence+in+mate+preference+during+speciation&rft.jtitle=Genetica&rft.date=2007&rft.volume=129&rft.issue=3&rft.au=Nosil+P%2C+Crespi+B%2C+Gries+R%2C+Gries+G&rft.pages=309-27&rft_id=info:pmid/16900317">  </li> <li id="_note-45"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-45">^</a> <cite style="FONT-STYLE: normal">Gross B, Rieseberg L (2005). "<a class="external text" title="http://jhered.oxfordjournals.org/cgi/content/full/96/3/241" rel="nofollow" href="http://jhered.oxfordjournals.org/cgi/content/full/96/3/241">The ecological genetics of homoploid hybrid speciation</a>". J. Hered. 96 (3): 241-52. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618301" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15618301">PMID 15618301</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+ecological+genetics+of+homoploid+hybrid+speciation&rft.jtitle=J.+Hered.&rft.date=2005&rft.volume=96&rft.issue=3&rft.au=Gross+B%2C+Rieseberg+L&rft.pages=241-52&rft_id=info:pmid/15618301&rft_id=http%3A%2F%2Fjhered.oxfordjournals.org%2Fcgi%2Fcontent%2Ffull%2F96%2F3%2F241">  </li> <li id="_note-46"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-46">^</a> <cite style="FONT-STYLE: normal">Comai L (2005). "The advantages and disadvantages of being polyploid". Nat. Rev. Genet. 6 (11): 836-46. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16304599" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16304599">PMID 16304599</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+advantages+and+disadvantages+of+being+polyploid&rft.jtitle=Nat.+Rev.+Genet.&rft.date=2005&rft.volume=6&rft.issue=11&rft.au=Comai+L&rft.pages=836-46&rft_id=info:pmid/16304599">  </li> <li id="_note-47"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-47">^</a> <cite style="FONT-STYLE: normal">Soltis P, Soltis D (2000). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10860970" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10860970">The role of genetic and genomic attributes in the success of polyploids</a>". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7051-7. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10860970" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10860970">PMID 10860970</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+genetic+and+genomic+attributes+in+the+success+of+polyploids&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.date=2000&rft.volume=97&rft.issue=13&rft.au=Soltis+P%2C+Soltis+D&rft.pages=7051-7&rft_id=info:pmid/10860970&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D10860970">  </li> <li id="_note-48"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-48">^</a> <cite style="FONT-STYLE: normal">Boucher Y, Douady CJ, Papke RT, Walsh DA, Boudreau ME, Nesbo CL, Case RJ, Doolittle WF (2003). "Lateral gene transfer and the origins of prokaryotic groups.". Annu Rev Genet 37: 283 - 328. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14616063" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14616063">PMID 14616063</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lateral+gene+transfer+and+the+origins+of+prokaryotic+groups.&rft.jtitle=Annu+Rev+Genet&rft.date=2003&rft.volume=37&rft.au=Boucher+Y%2C+Douady+CJ%2C+Papke+RT%2C+Walsh+DA%2C+Boudreau+ME%2C+Nesbo+CL%2C+Case+RJ%2C+Doolittle+WF&rft.pages=283+-+328">  </li> <li id="_note-49"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-49">^</a> <cite style="FONT-STYLE: normal">Walsh T (2006). "Combinatorial genetic evolution of multiresistance". Curr. Opin. Microbiol. 9 (5): 476-82. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16942901" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16942901">PMID 16942901</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Combinatorial+genetic+evolution+of+multiresistance&rft.jtitle=Curr.+Opin.+Microbiol.&rft.date=2006&rft.volume=9&rft.issue=5&rft.au=Walsh+T&rft.pages=476-82&rft_id=info:pmid/16942901">  </li> <li id="_note-50"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-50">^</a> <cite style="FONT-STYLE: normal">Kondo N, Nikoh N, Ijichi N, Shimada M, Fukatsu T (2002). "Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14280-5. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12386340" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12386340">PMID 12386340</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome+fragment+of+Wolbachia+endosymbiont+transferred+to+X+chromosome+of+host+insect&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.date=2002&rft.volume=99&rft.issue=22&rft.au=Kondo+N%2C+Nikoh+N%2C+Ijichi+N%2C+Shimada+M%2C+Fukatsu+T&rft.pages=14280-5&rft_id=info:pmid/12386340">  </li> <li id="_note-51"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-51">^</a> <cite style="FONT-STYLE: normal">Sprague G (1991). "Genetic exchange between kingdoms". Curr. Opin. Genet. Dev. 1 (4): 530-3. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1822285" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1822285">PMID 1822285</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+exchange+between+kingdoms&rft.jtitle=Curr.+Opin.+Genet.+Dev.&rft.date=1991&rft.volume=1&rft.issue=4&rft.au=Sprague+G&rft.pages=530-3&rft_id=info:pmid/1822285">  </li> <li id="_note-52"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-52">^</a> <cite style="FONT-STYLE: normal">Baldo A, McClure M (1999). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10438861" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10438861">Evolution and horizontal transfer of dUTPase-encoding genes in viruses and their hosts</a>". J. Virol. 73 (9): 7710-21. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10438861" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10438861">PMID 10438861</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evolution+and+horizontal+transfer+of+dUTPase-encoding+genes+in+viruses+and+their+hosts&rft.jtitle=J.+Virol.&rft.date=1999&rft.volume=73&rft.issue=9&rft.au=Baldo+A%2C+McClure+M&rft.pages=7710-21&rft_id=info:pmid/10438861&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D10438861">  </li> <li id="_note-53"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-53">^</a> <cite style="FONT-STYLE: normal">Poole A, Penny D (2007). "Evaluating hypotheses for the origin of eukaryotes". Bioessays 29 (1): 74-84. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17187354" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17187354">PMID 17187354</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluating+hypotheses+for+the+origin+of+eukaryotes&rft.jtitle=Bioessays&rft.date=2007&rft.volume=29&rft.issue=1&rft.au=Poole+A%2C+Penny+D&rft.pages=74-84&rft_id=info:pmid/17187354">  </li> <li id="_note-Dyall"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Dyall_0">^</a> <cite style="FONT-STYLE: normal">Dyall S, Brown M, Johnson P (2004). "Ancient invasions: from endosymbionts to organelles". Science 304 (5668): 253 – 7. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15073369" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15073369">PMID 15073369</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ancient+invasions%3A+from+endosymbionts+to+organelles&rft.jtitle=Science&rft.date=2004&rft.volume=304&rft.issue=5668&rft.au=Dyall+S%2C+Brown+M%2C+Johnson+P&rft.pages=253+%E2%80%93+7">  </li> <li id="_note-54"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-54">^</a> <cite style="FONT-STYLE: normal">Ochman H, Lerat E, Daubin V (2005). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15851673" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15851673">Examining bacterial species under the specter of gene transfer and exchange</a>". Proc. Natl. Acad. Sci. U.S.A. 102 Suppl 1: 6595-9. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15851673" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15851673">PMID 15851673</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Examining+bacterial+species+under+the+specter+of+gene+transfer+and+exchange&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.date=2005&rft.volume=102+Suppl+1&rft.au=Ochman+H%2C+Lerat+E%2C+Daubin+V&rft.pages=6595-9&rft_id=info:pmid/15851673&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D15851673">  </li> <li id="_note-55"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-55">^</a> <cite style="FONT-STYLE: normal">Lande R (1989). "Fisherian and Wrightian theories of speciation". Genome 31 (1): 221-7. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2687093" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2687093">PMID 2687093</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fisherian+and+Wrightian+theories+of+speciation&rft.jtitle=Genome&rft.date=1989&rft.volume=31&rft.issue=1&rft.au=Lande+R&rft.pages=221-7&rft_id=info:pmid/2687093">  </li> <li id="_note-Whitlock">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Whitlock_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Whitlock_1">b</a> <cite style="FONT-STYLE: normal">Whitlock M (2003). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12807795" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12807795">Fixation probability and time in subdivided populations</a>". Genetics 164 (2): 767-79. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12807795" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12807795">PMID 12807795</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fixation+probability+and+time+in+subdivided+populations&rft.jtitle=Genetics&rft.date=2003&rft.volume=164&rft.issue=2&rft.au=Whitlock+M&rft.pages=767-79&rft_id=info:pmid/12807795&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D12807795">  </li> <li id="_note-56"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-56">^</a> <cite style="FONT-STYLE: normal">Otto S, Whitlock M (1997). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9178020" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9178020">The probability of fixation in populations of changing size</a>". Genetics 146 (2): 723-33. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9178020" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9178020">PMID 9178020</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+probability+of+fixation+in+populations+of+changing+size&rft.jtitle=Genetics&rft.date=1997&rft.volume=146&rft.issue=2&rft.au=Otto+S%2C+Whitlock+M&rft.pages=723-33&rft_id=info:pmid/9178020&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D9178020">  </li> <li id="_note-Darwin">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Darwin_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-Darwin_1">b</a> <cite id="CITEREFDarwin1872" style="FONT-STYLE: normal"><a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Darwin, Charles</a> (1872), <a class="external text" title="http://darwin-online.org.uk/content/frameset?itemID=F391&viewtype=text&pageseq=1" rel="nofollow" href="http://darwin-online.org.uk/content/frameset?itemID=F391&viewtype=text&pageseq=1">The Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life.</a>, London: John Murray</cite> 6th edition; with additions and corrections. Retrieved on <a title="2006" href="http://en.wikipedia.org/wiki/2006">2006</a>-<a title="December 31" href="http://en.wikipedia.org/wiki/December_31">12-31</a> </li> <li id="_note-57"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-57">^</a> <cite style="FONT-STYLE: normal">Lande, R.; Arnold, S.J. (1983). "The measurement of selection on correlated characters". <a title="Evolution (journal)" href="http://en.wikipedia.org/wiki/Evolution_%28journal%29">Evolution</a> 37: 1210–1226.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+measurement+of+selection+on+correlated+characters&rft.jtitle=%5B%5BEvolution+%28journal%29%7CEvolution%5D%5D&rft.date=1983&rft.volume=37&rft.au=Lande%2C+R.&rft.pages=1210%26ndash%3B1226">  </li> <li id="_note-58"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-58">^</a> <cite style="FONT-STYLE: normal">Haldane J (1959). "The theory of natural selection today". Nature 183 (4663): 710-3. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13644170" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13644170">PMID 13644170</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+theory+of+natural+selection+today&rft.jtitle=Nature&rft.date=1959&rft.volume=183&rft.issue=4663&rft.au=Haldane+J&rft.pages=710-3&rft_id=info:pmid/13644170">  </li> <li id="_note-59"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-59">^</a> <cite style="FONT-STYLE: normal">Andersson M, Simmons L (2006). "Sexual selection and mate choice". Trends Ecol. Evol. (Amst.) 21 (6): 296-302. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16769428" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16769428">PMID 16769428</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sexual+selection+and+mate+choice&rft.jtitle=Trends+Ecol.+Evol.+%28Amst.%29&rft.date=2006&rft.volume=21&rft.issue=6&rft.au=Andersson+M%2C+Simmons+L&rft.pages=296-302&rft_id=info:pmid/16769428">  </li> <li id="_note-60"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-60">^</a> <cite style="FONT-STYLE: normal">Kokko H, Brooks R, McNamara J, Houston A (2002). "<a class="external text" title="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1691039&blobtype=pdf" rel="nofollow" href="http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1691039&blobtype=pdf">The sexual selection continuum</a>". Proc. Biol. Sci. 269 (1498): 1331-40. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12079655" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12079655">PMID 12079655</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+sexual+selection+continuum&rft.jtitle=Proc.+Biol.+Sci.&rft.date=2002&rft.volume=269&rft.issue=1498&rft.au=Kokko+H%2C+Brooks+R%2C+McNamara+J%2C+Houston+A&rft.pages=1331-40&rft_id=info:pmid/12079655&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Fpicrender.fcgi%3Fartid%3D1691039%26blobtype%3Dpdf">  </li> <li id="_note-61"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-61">^</a> <cite style="FONT-STYLE: normal">Hunt J, Brooks R, Jennions M, Smith M, Bentsen C, Bussière L (2004). "High-quality male field crickets invest heavily in sexual display but die young". Nature 432 (7020): 1024-7. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15616562" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15616562">PMID 15616562</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=High-quality+male+field+crickets+invest+heavily+in+sexual+display+but+die+young&rft.jtitle=Nature&rft.date=2004&rft.volume=432&rft.issue=7020&rft.au=Hunt+J%2C+Brooks+R%2C+Jennions+M%2C+Smith+M%2C+Bentsen+C%2C+Bussi%C3%A8re+L&rft.pages=1024-7&rft_id=info:pmid/15616562">  </li> <li id="_note-62"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-62">^</a> <cite style="FONT-STYLE: normal">Hoekstra H, Hoekstra J, Berrigan D, Vignieri S, Hoang A, Hill C, Beerli P, Kingsolver J (2001). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11470913" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11470913">Strength and tempo of directional selection in the wild</a>". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9157-60. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11470913" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11470913">PMID 11470913</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Strength+and+tempo+of+directional+selection+in+the+wild&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.date=2001&rft.volume=98&rft.issue=16&rft.au=Hoekstra+H%2C+Hoekstra+J%2C+Berrigan+D%2C+Vignieri+S%2C+Hoang+A%2C+Hill+C%2C+Beerli+P%2C+Kingsolver+J&rft.pages=9157-60&rft_id=info:pmid/11470913&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D11470913">  </li> <li id="_note-63"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-63">^</a> <cite style="FONT-STYLE: normal">Felsenstein (1979). "<a class="external text" title="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17248980" rel="nofollow" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17248980">Excursions along the Interface between Disruptive and Stabilizing Selection</a>" 93 (3): 773-795. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17248980" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17248980">PMID 17248980</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Excursions+along+the+Interface+between+Disruptive+and+Stabilizing+Selection&rft.date=1979&rft.volume=93&rft.issue=3&rft.au=Felsenstein&rft.pages=773-795&rft_id=info:pmid/17248980&rft_id=http%3A%2F%2Fwww.pubmedcentral.nih.gov%2Farticlerender.fcgi%3Ftool%3Dpubmed%26pubmedid%3D17248980">  </li> <li id="_note-64"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-64">^</a> <cite style="FONT-STYLE: normal">Orr H (2005). "The genetic theory of adaptation: a brief history". Nat. Rev. Genet. 6 (2): 119-27. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15716908" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15716908">PMID 15716908</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+genetic+theory+of+adaptation%3A+a+brief+history&rft.jtitle=Nat.+Rev.+Genet.&rft.date=2005&rft.volume=6&rft.issue=2&rft.au=Orr+H&rft.pages=119-27&rft_id=info:pmid/15716908">  </li> <li id="_note-65"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-65">^</a> <cite style="FONT-STYLE: normal">Buss D, Haselton M, Shackelford T, Bleske A, Wakefield J (1998). "Adaptations, exaptations, and spandrels". The American psychologist 53 (5): 533-48. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9612136" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9612136">PMID 9612136</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Adaptations%2C+exaptations%2C+and+spandrels&rft.jtitle=The+American+psychologist&rft.date=1998&rft.volume=53&rft.issue=5&rft.au=Buss+D%2C+Haselton+M%2C+Shackelford+T%2C+Bleske+A%2C+Wakefield+J&rft.pages=533-48&rft_id=info:pmid/9612136">  </li> <li id="_note-66"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-66">^</a> <cite style="FONT-STYLE: normal">Ho C, Prager E, Wilson A, Osuga D, Feeney R (1976). "Penguin evolution: protein comparisons demonstrate phylogenetic relationship to flying aquatic birds". J. Mol. Evol. 8 (3): 271-82. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=978750" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=978750">PMID 978750</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Penguin+evolution%3A+protein+comparisons+demonstrate+phylogenetic+relationship+to+flying+aquatic+birds&rft.jtitle=J.+Mol.+Evol.&rft.date=1976&rft.volume=8&rft.issue=3&rft.au=Ho+C%2C+Prager+E%2C+Wilson+A%2C+Osuga+D%2C+Feeney+R&rft.pages=271-82&rft_id=info:pmid/978750">  </li> <li id="_note-67"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-67">^</a> <cite style="FONT-STYLE: normal">Hoekstra H, Krenz J, Nachman M (2005). "Local adaptation in the rock pocket mouse (Chaetodipus intermedius): natural selection and phylogenetic history of populations". Heredity 94 (2): 217-28. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15523507" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15523507">PMID 15523507</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Local+adaptation+in+the+rock+pocket+mouse+%28Chaetodipus+intermedius%29%3A+natural+selection+and+phylogenetic+history+of+populations&rft.jtitle=Heredity&rft.date=2005&rft.volume=94&rft.issue=2&rft.au=Hoekstra+H%2C+Krenz+J%2C+Nachman+M&rft.pages=217-28&rft_id=info:pmid/15523507">  </li> <li id="_note-68"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-68">^</a> <cite style="FONT-STYLE: normal">Nowak M, Sigmund K (2004). "Evolutionary dynamics of biological games". Science 303 (5659): 793-9. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14764867" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14764867">PMID 14764867</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evolutionary+dynamics+of+biological+games&rft.jtitle=Science&rft.date=2004&rft.volume=303&rft.issue=5659&rft.au=Nowak+M%2C+Sigmund+K&rft.pages=793-9&rft_id=info:pmid/14764867">  </li> <li id="_note-69"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-69">^</a> <cite class="book" style="FONT-STYLE: normal"><a title="Martin Nowak" href="http://en.wikipedia.org/wiki/Martin_Nowak">Nowak, M</a> (2006). Evolutionary Dynamics: Exploring the Equations of Life. Belknap Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780674023383">ISBN 978-0674023383</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Evolutionary+Dynamics%3A+Exploring+the+Equations+of+Life&rft.aulast=Nowak&rft.aufirst=M&rft.date=2006&rft.pub=Belknap+Press&rft.isbn=978-0674023383">  </li> <li id="_note-70"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-70">^</a> <cite style="FONT-STYLE: normal">Axelrod R, Hamilton W (1981). "The evolution of cooperation". Science 211 (4489): 1390-6. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7466396" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7466396">PMID 7466396</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+evolution+of+cooperation&rft.jtitle=Science&rft.date=1981&rft.volume=211&rft.issue=4489&rft.au=Axelrod+R%2C+Hamilton+W&rft.pages=1390-6&rft_id=info:pmid/7466396">  </li> <li id="_note-71"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-71">^</a> <cite style="FONT-STYLE: normal">Sachs J (2006). "Cooperation within and among species". J. Evol. Biol. 19 (5): 1415-8; discussion 1426-36. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16910971" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16910971">PMID 16910971</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cooperation+within+and+among+species&rft.jtitle=J.+Evol.+Biol.&rft.date=2006&rft.volume=19&rft.issue=5&rft.au=Sachs+J&rft.pages=1415-8%3B+discussion+1426-36&rft_id=info:pmid/16910971">  </li> <li id="_note-72"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-72">^</a> {<cite style="FONT-STYLE: normal">Nowak M (2006). "Five rules for the evolution of cooperation". Science 314 (5805): 1560-3. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17158317" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17158317">PMID 17158317</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Five+rules+for+the+evolution+of+cooperation&rft.jtitle=Science&rft.date=2006&rft.volume=314&rft.issue=5805&rft.au=Nowak+M&rft.pages=1560-3&rft_id=info:pmid/17158317">  </li> <li id="_note-73"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-73">^</a> <cite style="FONT-STYLE: normal">Gavrilets S (2003). "Perspective: models of speciation: what have we learned in 40 years?". Evolution 57 (10): 2197-215. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14628909" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14628909">PMID 14628909</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Perspective%3A+models+of+speciation%3A+what+have+we+learned+in+40+years%3F&rft.jtitle=Evolution&rft.date=2003&rft.volume=57&rft.issue=10&rft.au=Gavrilets+S&rft.pages=2197-215&rft_id=info:pmid/14628909">  </li> <li id="_note-74"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-74">^</a> <cite style="FONT-STYLE: normal">Hoskin, CJ; Higgle, M; McDonald, KR; and Moritz, C (2005). "Reinforcement drives rapid allopatric speciation". Nature 437: 1353-1356. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1038/nature04004" rel="nofollow" href="http://dx.doi.org/10.1038/nature04004">10.1038/nature04004</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reinforcement+drives+rapid+allopatric+speciation&rft.jtitle=Nature&rft.date=2005&rft.volume=437&rft.aulast=Hoskin&rft.aufirst=CJ&rft.pages=1353-1356&rft_id=info:doi/10.1038%2Fnature04004">  </li> <li id="_note-75"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-75">^</a> <cite style="FONT-STYLE: normal">Savolainen, V; Anstett,M-C, Lexer, C, Hutton, I, Clarkson, JJ, Norup, MV, Powell, MP, Springate, D, Salamin, N & Baker, WJr (2006). "Sympatric speciation in palms on an oceanic island". Nature 441: 210-213. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/doi:10.1038/nature04566" rel="nofollow" href="http://dx.doi.org/doi:10.1038/nature04566">doi:10.1038/nature04566</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sympatric+speciation+in+palms+on+an+oceanic+island&rft.jtitle=Nature&rft.date=2006&rft.volume=441&rft.aulast=Savolainen&rft.aufirst=V&rft.pages=210-213&rft_id=info:doi/doi%3A10.1038%2Fnature04566">  </li> <li id="_note-76"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-76">^</a> <cite style="FONT-STYLE: normal">Barluenga, M; Stölting, KN, Salzburger, W, Muschick, M & Meyer, A (2006). "Sympatric speciation in Nicaraguan crater lake cichlid fish". Nature 439: 719-723. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1038/nature04325" rel="nofollow" href="http://dx.doi.org/10.1038/nature04325">10.1038/nature04325</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sympatric+speciation+in+Nicaraguan+crater+lake+cichlid+fish&rft.jtitle=Nature&rft.date=2006&rft.volume=439&rft.aulast=Barluenga&rft.aufirst=M&rft.pages=719-723&rft_id=info:doi/10.1038%2Fnature04325">  </li> <li id="_note-77"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-77">^</a> Isaak, Mark (2005). <a class="external text" title="http://www.talkorigins.org/indexcc/CC/CC150.html" rel="nofollow" href="http://www.talkorigins.org/indexcc/CC/CC150.html">Index to Creationist Claims, Claim CC150</a>. The TalkOrigins Archive. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 17" href="http://en.wikipedia.org/wiki/March_17">03-17</a>. </li> <li id="_note-78"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-78">^</a> <cite class="book" style="FONT-STYLE: normal">Leakey, Richard; Lewin, Roger (1996). The Sixth Extinction : Patterns of Life and the Future of Humankind. Anchor. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0385468091">ISBN 0-385-46809-1</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Sixth+Extinction+%3A+Patterns+of+Life+and+the+Future+of+Humankind&rft.aulast=Leakey&rft.aufirst=Richard&rft.date=1996&rft.pub=Anchor&rft.isbn=0-385-46809-1">  </li> <li id="_note-79"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-79">^</a> "Sequence comparisons suggest recent horizontal transfer of many <a title="Gene" href="http://en.wikipedia.org/wiki/Gene">genes</a> among diverse <a title="Species" href="http://en.wikipedia.org/wiki/Species">species</a> including across the boundaries of <a title="Phylogenetic" href="http://en.wikipedia.org/wiki/Phylogenetic">phylogenetic</a> 'domains'. Thus determining the phylogenetic history of a species cannot be done conclusively by determining evolutionary trees for single genes." See Melcher, M (2001). <a class="external text" title="http://opbs.okstate.edu/~melcher/MG/MGW3/MG334.html" rel="nofollow" href="http://opbs.okstate.edu/~melcher/MG/MGW3/MG334.html">Horizontal Gene Transfer</a>. <a title="Oklahoma State University" href="http://en.wikipedia.org/wiki/Oklahoma_State_University">Oklahoma State University</a>. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="April 18" href="http://en.wikipedia.org/wiki/April_18">04-18</a>. </li> <li id="_note-80"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-80">^</a> <cite style="FONT-STYLE: normal">Chimpanzee Sequencing and Analysis Consortium (2005). "Initial sequence of the chimpanzee genome and comparison with the human genome". <a title="Nature (journal)" href="http://en.wikipedia.org/wiki/Nature_%28journal%29">Nature</a> 437: 69-87. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1038/nature04072" rel="nofollow" href="http://dx.doi.org/10.1038/nature04072">10.1038/nature04072</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Initial+sequence+of+the+chimpanzee+genome+and+comparison+with+the+human+genome&rft.jtitle=%5B%5BNature+%28journal%29%7CNature%5D%5D&rft.date=2005&rft.volume=437&rft.au=Chimpanzee+Sequencing+and+Analysis+Consortium&rft.pages=69-87&rft_id=info:doi/10.1038%2Fnature04072">  </li> <li id="_note-81"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-81">^</a> <cite style="FONT-STYLE: normal">Varki, A; Altheide,TK (2005). "Comparing the human and chimpanzee genomes: searching for needles in a haystack". Genome Research 15 (12): 1746-58. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1101/gr.3737405." rel="nofollow" href="http://dx.doi.org/10.1101/gr.3737405.">10.1101/gr.3737405.</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparing+the+human+and+chimpanzee+genomes%3A+searching+for+needles+in+a+haystack&rft.jtitle=Genome+Research&rft.date=2005&rft.volume=15&rft.issue=12&rft.aulast=Varki&rft.aufirst=A&rft.pages=1746-58&rft_id=info:doi/10.1101%2Fgr.3737405.">  </li> <li id="_note-82"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-82">^</a> <cite style="FONT-STYLE: normal">Schweitzer M.H. et al (2005). "Soft-tissue vessels and cellular preservation in Tyrannosaurus rex". Science 307 (5717): 1952-1955.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Soft-tissue+vessels+and+cellular+preservation+in+%27%27Tyrannosaurus+rex%27%27&rft.jtitle=Science&rft.date=2005&rft.volume=307&rft.issue=5717&rft.au=Schweitzer+M.H.+%27%27et+al%27%27&rft.pages=1952-1955">  </li> <li id="_note-83"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-83">^</a> <cite class="book" style="FONT-STYLE: normal">Feduccia, Alan (1996). The Origin and Evolution of Birds. New Haven: Yale University Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0300064608">ISBN 0-300-06460-8</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Origin+and+Evolution+of+Birds&rft.au=Feduccia%2C+Alan&rft.date=1996&rft.pub=Yale+University+Press&rft.place=New+Haven">  </li> <li id="_note-84"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-84">^</a> <cite style="FONT-STYLE: normal">Daeschler, Edward B., Shubin, Neil H., & Jenkins Jr, Farish A. (April 2006). "<a class="external text" title="http://www.nature.com/nature/journal/v440/n7085/abs/nature04639.html" rel="nofollow" href="http://www.nature.com/nature/journal/v440/n7085/abs/nature04639.html">A Devonian tetrapod-like fish and the evolution of the tetrapod body plan</a>". <a title="Nature (journal)" href="http://en.wikipedia.org/wiki/Nature_%28journal%29">Nature</a> 440: 757–763. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1038/nature04639" rel="nofollow" href="http://dx.doi.org/10.1038/nature04639">10.1038/nature04639</a>. Retrieved on <a title="2006" href="http://en.wikipedia.org/wiki/2006">2006</a>-<a title="July 14" href="http://en.wikipedia.org/wiki/July_14">07-14</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Devonian+tetrapod-like+fish+and+the+evolution+of+the+tetrapod+body+plan&rft.jtitle=%5B%5BNature+%28journal%29%7CNature%5D%5D&rft.date=2006&rft.volume=440&rft.au=Daeschler%2C+Edward+B.%2C+Shubin%2C+Neil+H.%2C+%26+Jenkins+Jr%2C+Farish+A.&rft.pages=757%26ndash%3B763&rft_id=info:doi/10.1038%2Fnature04639&rft_id=http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv440%2Fn7085%2Fabs%2Fnature04639.html">  </li> <li id="_note-85"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-85">^</a> <cite style="FONT-STYLE: normal">Chen, FC; Li, WH (2001). "<a class="external text" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11170892" rel="nofollow" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11170892">Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees</a>". American Journal of Human Genetics 68: 444-56. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 16" href="http://en.wikipedia.org/wiki/March_16">03-16</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genomic+divergences+between+humans+and+other+hominoids+and+the+effective+population+size+of+the+common+ancestor+of+humans+and+chimpanzees&rft.jtitle=American+Journal+of+Human+Genetics&rft.date=2001&rft.volume=68&rft.aulast=Chen&rft.aufirst=FC&rft.pages=444-56&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3Dpubmed%26dopt%3DAbstract%26list_uids%3D11170892">  </li> <li id="_note-86"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-86">^</a> <cite style="FONT-STYLE: normal">Cooper, GM; et al. (2003). "<a class="external text" title="http://www.genome.org/cgi/content/full/13/5/813" rel="nofollow" href="http://www.genome.org/cgi/content/full/13/5/813">Quantitative Estimates of Sequence Divergence for Comparative Analysis of Mammalian Genomes</a>". Genome Research 13: 813-820. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 16" href="http://en.wikipedia.org/wiki/March_16">03-16</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quantitative+Estimates+of+Sequence+Divergence+for+Comparative+Analysis+of+Mammalian+Genomes&rft.jtitle=Genome+Research&rft.date=2003&rft.volume=13&rft.aulast=Cooper&rft.aufirst=GM&rft.pages=813-820&rft_id=http%3A%2F%2Fwww.genome.org%2Fcgi%2Fcontent%2Ffull%2F13%2F5%2F813">  </li> <li id="_note-c"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-c_0">^</a> The picture labeled "Human Chromosome 2 and its analogs in the apes" in the article Williams, Robert. <a class="external text" title="http://www.gate.net/~rwms/hum_ape_chrom.html" rel="nofollow" href="http://www.gate.net/~rwms/hum_ape_chrom.html">Comparison of the Human and Great Ape Chromosomes as Evidence for Common Ancestry</a>. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 17" href="http://en.wikipedia.org/wiki/March_17">03-17</a>. shows how humans have a single chromosome which is two separate chromosomes in the nonhuman apes. </li> <li id="_note-87"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-87">^</a> Wade, Nicholas. "<a class="external text" title="http://www.nytimes.com/2006/03/07/science/07evolve.html" rel="nofollow" href="http://www.nytimes.com/2006/03/07/science/07evolve.html">Still Evolving, Human Genes Tell New Story</a>", New York Times, 2006-03-07. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 17" href="http://en.wikipedia.org/wiki/March_17">03-17</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.type=newspaperArticle&rft.subject=News&rft.aufirst=Nicholas&rft.aulast=Wade&rft.title=Still+Evolving%2C+Human+Genes+Tell+New+Story&rft.identifier=http%3A%2F%2Fwww.nytimes.com%2F2006%2F03%2F07%2Fscience%2F07evolve.html&rft.publisher=New+York+Times&rft.date=2006-03-07">  </li> <li id="_note-88"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-88">^</a> <cite style="FONT-STYLE: normal">Voight, BF; Kudaravalli, S; Wen, X; and Pritchard, JK (2006). "<a class="external text" title="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0040072" rel="nofollow" href="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0040072">A Map of Recent Positive Selection in the Human Genome</a>". PLoS Biol 4 (3). <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1371/journal.pbio.0040072" rel="nofollow" href="http://dx.doi.org/10.1371/journal.pbio.0040072">10.1371/journal.pbio.0040072</a>. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 17" href="http://en.wikipedia.org/wiki/March_17">03-17</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Map+of+Recent+Positive+Selection+in+the+Human+Genome&rft.jtitle=PLoS+Biol&rft.date=2006&rft.volume=4&rft.issue=3&rft.aulast=Voight&rft.aufirst=BF&rft_id=info:doi/10.1371%2Fjournal.pbio.0040072&rft_id=http%3A%2F%2Fbiology.plosjournals.org%2Fperlserv%2F%3Frequest%3Dget-document%26doi%3D10.1371%2Fjournal.pbio.0040072"> , states the <a title="International HapMap Project" href="http://en.wikipedia.org/wiki/International_HapMap_Project">International HapMap Project</a> is "providing the strongest evidence yet that humans are still evolving" and details some of that evidence. </li> <li id="_note-89"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-89">^</a> <cite style="FONT-STYLE: normal">Petrov, DA; Hartl, DL (2000). "<a class="external text" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10833048" rel="nofollow" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10833048">Pseudogene evolution and natural selection for a compact genome</a>". Journal of Heredity 91 (3): 221-227. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="March 16" href="http://en.wikipedia.org/wiki/March_16">03-16</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pseudogene+evolution+and+natural+selection+for+a+compact+genome&rft.jtitle=Journal+of+Heredity&rft.date=2000&rft.volume=91&rft.issue=3&rft.aulast=Petrov&rft.aufirst=DA&rft.pages=221-227&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3Dpubmed%26dopt%3DAbstract%26list_uids%3D10833048">  </li> <li id="_note-90"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-90">^</a> <cite style="FONT-STYLE: normal">Okamoto N, Inouye I. (2005). "A secondary symbiosis in progress". Science 310 (5746): 287.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+secondary+symbiosis+in+progress&rft.jtitle=Science&rft.date=2005&rft.volume=310&rft.issue=5746&rft.au=Okamoto+N%2C+Inouye+I.&rft.pages=287">  </li> <li id="_note-91"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-91">^</a> <cite style="FONT-STYLE: normal">Okamoto, N; Inouye, I (2006). "Hatena arenicola gen. et sp. nov., a Katablepharid Undergoing Probable Plastid Acquisition". Protist 157 (4): 401-419.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%27%27Hatena+arenicola%27%27+gen.+et+sp.+nov.%2C+a+Katablepharid+Undergoing+Probable+Plastid+Acquisition&rft.jtitle=Protist&rft.date=2006&rft.volume=157&rft.issue=4&rft.aulast=Okamoto&rft.aufirst=N&rft.pages=401-419">  </li> <li id="_note-HowStuffWorks">^ <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-HowStuffWorks_0">a</a> <a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-HowStuffWorks_1">b</a> <cite id="CITEREFMarshall2001" style="FONT-STYLE: normal">Marshall, Brain (2001), "<a class="external text" title="http://science.howstuffworks.com/evolution.htm/printable" rel="nofollow" href="http://science.howstuffworks.com/evolution.htm/printable">How Evolution Works</a>", HowStuffWorks</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=How+Evolution+Works&rft.title=How+Evolution+Works&rft.aulast=Marshall&rft.aufirst=Brain&rft.date=2001&rft_id=http%3A%2F%2Fscience.howstuffworks.com%2Fevolution.htm%2Fprintable"> . </li> <li id="_note-92"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-92">^</a> <cite id="CITEREFIsaak2005" style="FONT-STYLE: normal">Isaak, Mark (2005), "<a class="external text" title="http://www.talkorigins.org/indexcc/CB/CB090.html" rel="nofollow" href="http://www.talkorigins.org/indexcc/CB/CB090.html">Claim CB090: Evolution without abiogenesis</a>", <a title="TalkOrigins Archive" href="http://en.wikipedia.org/wiki/TalkOrigins_Archive">TalkOrigins Archive</a></cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Claim+CB090%3A+Evolution+without+abiogenesis&rft.title=Claim+CB090%3A+Evolution+without+abiogenesis&rft.aulast=Isaak&rft.aufirst=Mark&rft.date=2005&rft_id=http%3A%2F%2Fwww.talkorigins.org%2Findexcc%2FCB%2FCB090.html"> . </li> <li id="_note-93"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-93">^</a> <cite id="CITEREFDarwin1860" style="FONT-STYLE: normal"><a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Darwin, Charles</a> (1860), <a title="The Origin of Species" href="http://en.wikipedia.org/wiki/The_Origin_of_Species">On the Origin of Species</a> (2nd ed.), London: John Murray</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=%5B%5BThe+Origin+of+Species%7COn+the+Origin+of+Species%5D%5D&rft.title=%5B%5BThe+Origin+of+Species%7COn+the+Origin+of+Species%5D%5D&rft.aulast=Darwin&rft.aufirst=Charles&rft.date=1860&rft.edition=2nd&rft.pub=John+Murray">  <a class="external text" title="http://darwin-online.org.uk/content/frameset?itemID=F376&viewtype=text&pageseq=508" rel="nofollow" href="http://darwin-online.org.uk/content/frameset?itemID=F376&viewtype=text&pageseq=508">p. 490</a> </li> <li id="_note-94"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-94">^</a> <cite id="CITEREFIsaak2005" style="FONT-STYLE: normal">Isaak, Mark (2005), "<a class="external text" title="http://www.talkorigins.org/indexcc/CB/CB050.html" rel="nofollow" href="http://www.talkorigins.org/indexcc/CB/CB050.html">Claim CB050: Abiogenesis is speculation?</a>", <a title="TalkOrigins Archive" href="http://en.wikipedia.org/wiki/TalkOrigins_Archive">TalkOrigins Archive</a></cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Claim+CB050%3A+Abiogenesis+is+speculation%3F&rft.title=Claim+CB050%3A+Abiogenesis+is+speculation%3F&rft.aulast=Isaak&rft.aufirst=Mark&rft.date=2005&rft_id=http%3A%2F%2Fwww.talkorigins.org%2Findexcc%2FCB%2FCB050.html"> . </li> <li id="_note-95"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-95">^</a> <cite style="FONT-STYLE: normal">Valentine J, Jablonski D (2003). "<a class="external text" title="http://www.ijdb.ehu.es/web/paper.php?doi=14756327" rel="nofollow" href="http://www.ijdb.ehu.es/web/paper.php?doi=14756327">Morphological and developmental macroevolution: a paleontological perspective</a>". Int. J. Dev. Biol. 47 (7-8): 517-22. <a class="external" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756327" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14756327">PMID 14756327</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Morphological+and+developmental+macroevolution%3A+a+paleontological+perspective&rft.jtitle=Int.+J.+Dev.+Biol.&rft.date=2003&rft.volume=47&rft.issue=7-8&rft.au=Valentine+J%2C+Jablonski+D&rft.pages=517-22&rft_id=info:pmid/14756327&rft_id=http%3A%2F%2Fwww.ijdb.ehu.es%2Fweb%2Fpaper.php%3Fdoi%3D14756327">  </li> <li id="_note-96"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-96">^</a> An overview of the philosophical, religious, and cosmological controversies by a philosopher who strongly supports evolution is: <cite class="book" style="FONT-STYLE: normal"><a title="Daniel Dennett" href="http://en.wikipedia.org/wiki/Daniel_Dennett">Dennett, D</a> (1995). <a title="Darwin's Dangerous Idea" href="http://en.wikipedia.org/wiki/Darwin%27s_Dangerous_Idea">Darwin's Dangerous Idea: Evolution and the Meanings of Life</a>. Simon & Schuster. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780684824710">ISBN 978-0684824710</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=%5B%5BDarwin%27s+Dangerous+Idea%7CDarwin%27s+Dangerous+Idea%3A+Evolution+and+the+Meanings+of+Life%5D%5D&rft.aulast=Dennett&rft.aufirst=D&rft.date=1995&rft.pub=Simon+%26+Schuster&rft.isbn=978-0684824710">  </li> <li id="_note-97"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-97">^</a> For more information on the scientific and social reception of evolution in the 19th and early 20th centuries, see: <cite class="book" style="FONT-STYLE: normal"><a title="Peter J. Bowler" href="http://en.wikipedia.org/wiki/Peter_J._Bowler">Bowler, PJ</a> (2003). Evolution: The History of an Idea, Third Edition, Completely Revised and Expanded. University of California Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780520236936">ISBN 978-0520236936</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Evolution%3A+The+History+of+an+Idea%2C+Third+Edition%2C+Completely+Revised+and+Expanded&rft.aulast=Bowler&rft.aufirst=PJ&rft.date=2003&rft.pub=University+of+California+Press&rft.isbn=978-0520236936">  </li> <li id="_note-98"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-98">^</a> Sarfati, J. <a class="external text" title="http://www.answersingenesis.org/home/area/re1/chapter1.asp" rel="nofollow" href="http://www.answersingenesis.org/home/area/re1/chapter1.asp">Evolution & creation, science & religion, facts & bias</a>. <a class="external text" title="http://www.answersingenesis.org/" rel="nofollow" href="http://www.answersingenesis.org/">Answers in Genesis</a>. Retrieved on <a title="2007" href="http://en.wikipedia.org/wiki/2007">2007</a>-<a title="April 16" href="http://en.wikipedia.org/wiki/April_16">04-16</a>. </li> <li id="_note-wmap"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-wmap_0">^</a> <cite style="FONT-STYLE: normal">Spergel, D. N.; et al. (2003). "First-Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Determination of Cosmological Parameters". The Astrophysical Journal Supplement Series 148: 175—194. <a title="Digital object identifier" href="http://en.wikipedia.org/wiki/Digital_object_identifier">DOI</a>:<a class="external text" title="http://dx.doi.org/10.1086/377226" rel="nofollow" href="http://dx.doi.org/10.1086/377226">10.1086/377226</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=First-Year+Wilkinson+Microwave+Anisotropy+Probe+%28WMAP%29+Observations%3A+Determination+of+Cosmological+Parameters&rft.jtitle=The+Astrophysical+Journal+Supplement+Series&rft.date=2003&rft.volume=148&rft.aulast=Spergel&rft.aufirst=D.+N.&rft.pages=175%26mdash%3B194&rft_id=info:doi/10.1086%2F377226">  </li> <li id="_note-zircon"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-zircon_0">^</a> <cite style="FONT-STYLE: normal">Wilde, S. A.; Valley J. W., Peck W. H. and Graham C. M. (2001). "Evidence from detrital zircons for the existence of continental crust and oceans on the Earth 4.4 Gyr ago". Nature 409: 175—178.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evidence+from+detrital+zircons+for+the+existence+of+continental+crust+and+oceans+on+the+Earth+4.4+Gyr+ago&rft.jtitle=Nature&rft.date=2001&rft.volume=409&rft.aulast=Wilde&rft.aufirst=S.+A.&rft.pages=175%26mdash%3B178">  </li> <li id="_note-99"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-99">^</a> <a title="Charles Darwin" href="http://en.wikipedia.org/wiki/Charles_Darwin">Darwin</a> strongly disagreed with attempts by <a title="Herbert Spencer" href="http://en.wikipedia.org/wiki/Herbert_Spencer">Herbert Spencer</a> and other to extrapolate evolutionary ideas to all possible subject matters; see <cite class="book" style="FONT-STYLE: normal"><a title="Mary Midgley" href="http://en.wikipedia.org/wiki/Mary_Midgley">Midgley, M</a> (2004). The Myths we Live By. Routledge, 62. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780415340779">ISBN 978-0415340779</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Myths+we+Live+By&rft.aulast=Midgley&rft.aufirst=M&rft.date=2004&rft.pub=Routledge&rft.pages=62&rft.isbn=978-0415340779">  </li> <li id="_note-100"><a title="" href="http://en.wikipedia.org/wiki/Evolution#_ref-100">^</a> On the history of eugenics and evolution, see <cite class="book" style="FONT-STYLE: normal"><a title="Daniel Kevles" href="http://en.wikipedia.org/wiki/Daniel_Kevles">Kevles, D</a> (1998). In the Name of Eugenics: Genetics and the Uses of Human Heredity. Harvard University Press. <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=9780674445574">ISBN 978-0674445574</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=In+the+Name+of+Eugenics%3A+Genetics+and+the+Uses+of+Human+Heredity&rft.aulast=Kevles&rft.aufirst=D&rft.date=1998&rft.pub=Harvard+University+Press&rft.isbn=978-0674445574">  </li></ol></div> <h2>Further reading</h2>Introductory<ul> <li>Mayr, E., What Evolution Is. (Basic Books, 2002) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0465044263">ISBN 0-465-04426-3</a> </li></ul>Historical<ul> <li>Larson, EJ., Evolution: The Remarkable History of a Scientific Theory. (Modern Library, 2004) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0679642889">ISBN 0-679-64288-9</a> </li> <li>Zimmer, C., Evolution: The Triumph of an Idea. (Academic Internet Publishers, 2006) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0060199067">ISBN 0-060-19906-7</a> </li></ul>Advanced<ul> <li>Carroll, SB., Endless Forms Most Beautiful: The New Science of Evo Devo and the Making of the Animal Kingdom. (W. W. Norton & Company, 2005) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0393060160">ISBN 0-393-06016-0</a> </li> <li>Williams, GC., Adaptation and Natural Selection: A Critique of some Current Evolutionary Thought. (Princeton University Press, 1966) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0691023573">ISBN 0-691-02357-3</a> </li> <li>Dawkins, R., The Selfish Gene. (Oxford University Press, USA; 3rd edition, 2006) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=0199291144">ISBN 0-199-29114-4</a> </li> <li>Gould, SJ, Wonderful Life: The Burgess Shale and the Nature of History. (W. W. Norton & Company, 1990) <a class="internal" href="http://en.wikipedia.org/w/index.php?title=Special:Booksources&isbn=039330700X">ISBN 0-393-30700-X</a> </li></ul> <h2>External links</h2><div class="infobox sisterproject noprint plainlinks" id="section_SpokenWikipedia"><div style="TEXT-ALIGN: center"><a class="internal" title="Evolution.ogg" href="http://upload.wikimedia.org/wikipedia/en/4/4d/Evolution.ogg">Listen to this article</a> · <a title="Image:Evolution.ogg" href="http://en.wikipedia.org/wiki/Image:Evolution.ogg">(info)</a> · <a class="external text" title="http://tools.wikimedia.de/~gmaxwell/jorbis/JOrbisPlayer.php?path=Evolution.ogg&wiki=en" rel="nofollow" href="http://tools.wikimedia.de/~gmaxwell/jorbis/JOrbisPlayer.php?path=Evolution.ogg&wiki=en">play in browser</a></div><div style="FLOAT: left; MARGIN-LEFT: 5px"><div class="floatnone"><a class="image" title="Spoken Wikipedia" href="http://en.wikipedia.org/wiki/Image:Sound-icon.svg"><img height="34" alt="Spoken Wikipedia" width="45" longdesc="/wiki/Image:Sound-icon.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/4/47/Sound-icon.svg/45px-Sound-icon.svg.png" /></a></div></div><div style="FONT-SIZE: xx-small; MARGIN-LEFT: 60px; LINE-HEIGHT: 1.6em">This audio file was created from an article revision dated <a title="2005" href="http://en.wikipedia.org/wiki/2005">2005</a>-<a title="April 18" href="http://en.wikipedia.org/wiki/April_18">04-18</a>, and may not reflect subsequent edits to the article. (<a title="Wikipedia:Media help" href="http://en.wikipedia.org/wiki/Wikipedia:Media_help">Audio help</a>)</div><div style="CLEAR: both; TEXT-ALIGN: center"><a title="Wikipedia:Spoken articles" href="http://en.wikipedia.org/wiki/Wikipedia:Spoken_articles">More spoken articles</a></div></div><div class="metadata topicon" id="spoken-icon" style="DISPLAY: none; RIGHT: 30px"><div style="OVERFLOW: hidden; WIDTH: 16px; POSITION: relative; HEIGHT: 12px"><div style="FONT-SIZE: 12px; OVERFLOW: hidden; LINE-HEIGHT: 12px; LETTER-SPACING: 16px; POSITION: absolute"><a class="internal" title="Evolution.ogg" href="http://upload.wikimedia.org/wikipedia/en/4/4d/Evolution.ogg">   </a></div><a class="image" title="This is a spoken article. Click here to listen." href="http://en.wikipedia.org/wiki/Image:Sound-icon.svg"><img height="12" alt="This is a spoken article. Click here to listen." width="16" longdesc="/wiki/Image:Sound-icon.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/4/47/Sound-icon.svg/16px-Sound-icon.svg.png" /></a></div></div>General information

<ul>

<li>1<a class="external text" title="http://evolution.berkeley.edu/" rel="nofollow" href="http://evolution.berkeley. ~~진화 - 한 상태에서 다른 상태로 서서히~~edu/">Understanding Evolution</a> from <a title="University of California, ~~순서 있게 지속적으로 변화하고 발달하는 과정~~Berkeley" href="http://en. wikipedia.org/wiki/University_of_California%2C_Berkeley">University of California, Berkeley</a> </li> <li>2<a class="external text" title="http://nationalacademies. org/evolution/" rel="nofollow" href="http://nationalacademies.org/evolution/">National Academies Evolution Resources</a> </li> <li><a class="external text" title="http://www.newscientist.com/channel/life/evolution" rel="nofollow" href="http://www.newscientist.com/channel/life/evolution">Everything you wanted to know about evolution</a> (~~유전학에서~~provided by <a title="New Scientist" href="http://en.wikipedia.org/wiki/New_Scientist">New Scientist</a>) ~~전성설(前成說) - 인간을 포함한 모든 동~~ </li> <li><a class="external text" title="http://science.howstuffworks.com/evolution.htm/printable" rel="nofollow" href="http://science.howstuffworks.com/evolution.htm/printable">Howstuffworks.com &~~middot~~mdash; ~~식물의 기원과 번식에 대한 이론~~How Evolution Works</a> </li> <li><a class="external text" title="http://anthro.palomar.edu/synthetic/" rel="nofollow" href="http://anthro.palomar. edu/synthetic/">Synthetic Theory Of Evolution: An Introduction to Modern Evolutionary Concepts and Theories</a> </li> <li><a class="external text" title="http://www.genomenewsnetwork.org/categories/index/genome/evolution.php" rel="nofollow" href="http://www.genomenewsnetwork.org/categories/index/genome/evolution.php">Evolution News from Genome News Network (GNN)</a> </li>

</ul>

History of evolution~~[[Evolution]]~~ <~~br /~~ul>[ <li><a class="external text" title="http://~~evolomics~~darwin-online.org ~~Evolomics~~.uk" rel="nofollow" href="http://darwin-online.org~~] | [~~.uk/">The Complete Work of Charles Darwin Online</a>, Darwin's writings and ancillary texts by other authors </li> <li><a class="external text" title="http://www.rationalrevolution.net/articles/understanding_evolution.htm" rel="nofollow" href="http://~~evolome~~www.rationalrevolution.~~org Evolome~~net/articles/understanding_evolution.~~org]~~htm">Understanding Evolution: History, Theory, Evidence, and Implications</a> Deals heavily with the history of thoughts about evolution </li></ul>

Anonymous user

210.218.222.14

Changes

Evolution

Navigation menu

Views

Personal tools

Related Links

Advertisements

Search

Tools

Related Links[Edit]