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<p><strong>Dehydroepiandrosterone</strong> (<strong>DHEA</strong>), is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an [[autocrine mechanism]])]. DHEA is the precursor of androstenedione, testosterone and estrogen. It is the most abundant hormone in the human body.<br /><table id="drugInfoBox" style="CLEAR: right; BACKGROUND: #ffffff; FLOAT: right; MARGIN: 0px 0px 0.5em 1em" cellpadding="1" width="280" align="right" border="0" class="toccolours"> <tbody> <tr> <td align="center" colspan="2"><a class="image" title="" href="http://en.wikipedia.org/wiki/Image:Dehydroepiandrosterone.png"><img height="118" alt="" src="http://upload.wikimedia.org/wikipedia/en/9/98/Dehydroepiandrosterone.png" width="177" longdesc="/wiki/Image:Dehydroepiandrosterone.png" /></a></td> </tr> <tr> <td align="center" colspan="2"> <div style="FONT-SIZE: medium; LINE-HEIGHT: 167%">Dehydroepiandrosterone</div> </td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Systematic (<a title="International Union of Pure and Applied Chemistry nomenclature" href="http://en.wikipedia.org/wiki/International_Union_of_Pure_and_Applied_Chemistry_nomenclature">IUPAC</a>) name</strong></td> </tr> <tr> <td style="VERTICAL-ALIGN: top; TEXT-ALIGN: center" bgcolor="#eeeeee" colspan="2"><span style="FONT-SIZE: 11px">3&szlig;-hydroxy-5-androsten-17-one</span></td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Identifiers</strong></td> </tr> <tr> <td width="90" bgcolor="#ddeeff"><a title="CAS registry number" href="http://en.wikipedia.org/wiki/CAS_registry_number">CAS number</a></td> <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1" href="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=53-43-0&amp;rn=1" rel="nofollow">53-43-0</a></span></td> </tr> <tr> <td bgcolor="#ddeeff"><a title="Anatomical Therapeutic Chemical Classification System" href="http://en.wikipedia.org/wiki/Anatomical_Therapeutic_Chemical_Classification_System">ATC code</a></td> <td bgcolor="#eeeeee"><a title="ATC code A14" href="http://en.wikipedia.org/wiki/ATC_code_A14">A14</a><span class="reflink plainlinksneverexpand"><a class="external text" title="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07" href="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A14AA07" rel="nofollow">AA07</a></span></td> </tr> <tr> <td bgcolor="#ddeeff"><a title="PubChem" href="http://en.wikipedia.org/wiki/PubChem">PubChem</a></td> <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a class="external text" title="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76" rel="nofollow">76</a></span></td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Chemical data</strong></td> </tr> <tr> <td bgcolor="#ddeeff"><a title="Chemical formula" href="http://en.wikipedia.org/wiki/Chemical_formula">Formula</a></td> <td bgcolor="#eeeeee"><a title="Carbon" href="http://en.wikipedia.org/wiki/Carbon"><span style="FONT-WEIGHT: bold; COLOR: rgb(0,0,0)">C</span></a>₁₉<a title="Hydrogen" href="http://en.wikipedia.org/wiki/Hydrogen"><span style="FONT-WEIGHT: bold; COLOR: rgb(77,77,77)">H</span></a>₂₈<a title="Oxygen" href="http://en.wikipedia.org/wiki/Oxygen"><span style="FONT-WEIGHT: bold; COLOR: rgb(116,35,35)">O</span></a>₂^&nbsp;</td> </tr> <tr> <td bgcolor="#ddeeff"><a title="Molecular mass" href="http://en.wikipedia.org/wiki/Molecular_mass">Mol. mass</a></td> <td bgcolor="#eeeeee">288.43</td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Physical data</strong></td> </tr> <tr> <td bgcolor="#ddeeff"><a title="Melting point" href="http://en.wikipedia.org/wiki/Melting_point">Melt. point</a></td> <td bgcolor="#eeeeee">148.5&nbsp;&deg;C (299&nbsp;&deg;F)</td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Pharmacokinetic data</strong></td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Bioavailability" href="http://en.wikipedia.org/wiki/Bioavailability">Bioavailability</a></td> <td bgcolor="#eeeeee">&nbsp;?</td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Drug metabolism" href="http://en.wikipedia.org/wiki/Drug_metabolism">Metabolism</a></td> <td bgcolor="#eeeeee"><a title="Liver" href="http://en.wikipedia.org/wiki/Liver">Hepatic</a></td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Biological half-life" href="http://en.wikipedia.org/wiki/Biological_half-life">Half life</a></td> <td bgcolor="#eeeeee">12 hours</td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Excretion" href="http://en.wikipedia.org/wiki/Excretion">Excretion</a></td> <td bgcolor="#eeeeee"><a title="Urine" href="http://en.wikipedia.org/wiki/Urine">Urinary</a>:?%</td> </tr> <tr> <td bgcolor="#dddddd" colspan="2"><strong>Therapeutic considerations</strong></td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Pregnancy category" href="http://en.wikipedia.org/wiki/Pregnancy_category">Pregnancy cat.</a></td> <td bgcolor="#eeeeee"> <p>?</p> </td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Regulation of therapeutic goods" href="http://en.wikipedia.org/wiki/Regulation_of_therapeutic_goods">Legal status</a></td> <td bgcolor="#eeeeee"> <p>Commercially available<br /> (<a title="United States" href="http://en.wikipedia.org/wiki/United_States">US</a>)</p> </td> </tr> <tr> <td style="VERTICAL-ALIGN: top" bgcolor="#ddeeff"><a title="Route of administration" href="http://en.wikipedia.org/wiki/Route_of_administration">Routes</a></td> <td bgcolor="#eeeeee"><a title="Mouth" href="http://en.wikipedia.org/wiki/Mouth">Oral</a></td> </tr> </tbody></table></p>