0
edits
Changes
From Opengenome.net
no edit summary
<p><strong>DSCAM</strong> and <strong>Dscam</strong> are both acronyms for <strong>Down Syndrome Cell Adhesion Molecule</strong>. The case difference is significant: <em>DSCAM</em> refers to the human protein, and <em>Dscam</em> refers to its analog in <a title="Drosophila" href="http://en.wikipedia.org/wiki/Drosophila">Drosophila</a>.</p>
<p>Of particular interest is that <em>Dscam</em> has over 38,000 <a title="Alternative splicing" href="http://en.wikipedia.org/wiki/Alternative_splicing"><font color="#810081">alternative splicing</font></a> forms from four variable <a title="Exon" href="http://en.wikipedia.org/wiki/Exon">exon</a> clusters. (12, 48, 33 and 2 alternatives respectively.)</p>
<div class="editsection" style="FLOAT: right; MARGIN-LEFT: 5px"p>[<a title="Edit section: See also" href="http://en.wikipedia.org/w/index.php?title=DSCAM&action=edit&nbsp;section=1">edit</a>]</div><p><a id="See_also" name="See_also"></a></p>
<h2>See also</h2>
<ul>
<li><a title="Down syndrome" href="http://en.wikipedia.org/wiki/Down_syndrome">Down syndrome</a> </li>
</ul>
<h2>References</h2>
<ol>
<li>Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. (2004) Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004 Sep 3;118(5):619-33. <a title="Entrez" href="http://en.wikipedia.org/wiki/Entrez">Entrez PubMed</a> <a class="external text" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15339666" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15339666">15339666</a> </li>
<li>Watson FL, Puttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005 Sep 16;309(5742):1874-8. Epub 2005 Aug 18. <a title="Entrez" href="http://en.wikipedia.org/wiki/Entrez">Entrez PubMed</a> <a class="external text" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16109846" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16109846">16109846</a> </li>
<li>Chen BE, Kondo M, Garnier A, Watson FL, Puettmann-Holgado R, Lamar DR, Schmucker D. (2006) The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell. 2006 May 5;125(3):607-20. <a title="Entrez" href="http://en.wikipedia.org/wiki/Entrez">Entrez PubMed</a> <a class="external text" title="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16678102" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16678102">16678102</a></li>
</ol>
