Changes

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-12 (IL-12) </strong>Heterodimer containing a p35 subunit of 30-33, p40 subunit of 35-44. NK cells stimulatory factor (NKSF); cytotoxic lymphocyte maturation factor (CLMF)</td> <tdbgcolor="#cccccc">&nbsp;Macrophages and dendritic cells&nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Important factor in inducing differentiation of Th1 subset helper T cells. Also induces interferon gamma production by T cells and NK cells and enhances NK cell activity.&nbsp;</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-14 (IL-14) </strong>60. High molecular weight B cell growth factor (HMW-BCGF)</td> <tdbgcolor="#cccccc">&nbsp;T cells&nbsp; </td> <tdbgcolor="#cccccc">&nbsp;Enhances B celss proliferation, inhibits antibody synthesis.&nbsp;</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-16 (IL-16) </strong>homotetramer 60; monomer ~17. Lymphocyte chemotatic factor (LCF)</td> <tdbgcolor="#cccccc">&nbsp;T cells &nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Stomulates migration of CD4+ T cells, CD4+ monocytes, and eosinophils. Binding of IL-16 by CD4 inhibits HIV sinfection of CD4+ cells&nbsp;.</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-18 (IL-18) </strong>18.2, Interferon gamma-inducing factor (IGIF)</td> <tdbgcolor="#cccccc">&nbsp;Cells of the monocytic lineage and dendritic cells&nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Promotes differentiation of Th1 subset of helper T cells. Induces interferon gamma production of T cells and enhances NK cell cytotoxicity.&nbsp;</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-20 (IL-20) </strong></td> <tdbgcolor="#cccccc">&nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Newly discovered cytokine has effects in epidermal tissues; no immune system specific effects yet known.</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-22 (IL-22)</strong></td> <tdbgcolor="#cccccc">&nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Newly discovered member of IL-10 cytokine family.</td>

<td><strong>&nbsp;Interleukin-23 (IL-23)</strong>Heterodimer of p40 subunit of IL-12 (35-40) and p19 (18.7)</td> <td>&nbsp;Activated dendritic cells</td> <td>&nbsp;Many of the same biological activities as IL-12&nbsp;</td>

<tdbgcolor="#cccccc"><strong>&nbsp;Interleukin-24 (IL-24)</strong>23. IL10B; MDA7 (melanoma differentiation association protein7)</td> <tdbgcolor="#cccccc">&nbsp;Up-regulated in melanoma cells&nbsp;</td> <tdbgcolor="#cccccc">&nbsp;Indeuces TNF-&alpha; and IFN-&gamma; and low levels of IL-1&beta;, IL-12, and GM-CSF in human PBMC. Induces selective anti-cancer properties in breast carcinoma cells by promoting p53 independent apoptosis. Member of the IL-10 family.&nbsp;</td>

<td>&nbsp;New member of the IL-17 family. Induces production of IL-4, IL-5, IL-13, and eotaxin. In vivo introduction of IL-25 into the lung can result in airway disease, involving cytokine production, tissue reorganization, mucus secretion, and airway hyperreactivity.</td>