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<a href="http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_atmPathway.gif">http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_atmPathway.gif</a><br /><br />Ataxia telangiectasia-mutated gene(ATM)은 tumor suppressor같은 역할을 하는 protein kinase를 암호화한다.<br />DNA의 damage를 ionixing radiation에 의해서 ATM 을 활성화하는 것은 DNA repair를 자극하고, cell cycle을 통해서 progression을 Block한다.<br />ATM gene의 돌연변이는 같은 암들의 병에 걸리기 쉬운 경향을 유전적으로 전달하는 것을 포함한 ataxia telangiectasia 질병의 원인이 된다.<br /><br />Pathway Interaction<br /><table style="WIDTH: 688px; HEIGHT: 563px" cellspacing="1" cellpadding="1" width="688" summary="" border="1"> <tbody> <tr> <td> </td> <td> </td> </tr> <tr> <td> <p align="center">CHK1</p> </td> <td> <p align="center">ATM</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">p53-mdm2</p> </td> </tr> <tr> <td> <p align="center">CHK2</p> </td> <td> <p align="center">ATM</p> </td> </tr> <tr> <td> <p align="center">p53</p> </td> <td> <p align="center">p21</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">GADD45</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">mdm2</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Apoptosis</p> </td> </tr> <tr> <td> <p align="center">p73</p> </td> <td> <p align="center">C-Ab1</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Apoptosis</p> </td> </tr> <tr> <td> <p align="center">ATM</p> </td> <td> <p align="center">CHK2</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">CHK1</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">RPA</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">C-Abl</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">mdm2</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">CTIP</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">NFkB</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">p53</p> </td> </tr> <tr> <td> <p align="center">NFkB</p> </td> <td> <p align="center">IKBa</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Apoptosis</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">ATM</p> </td> </tr> <tr> <td> <p align="center">RAD51</p> </td> <td> <p align="center">CAD1</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BRCA1</p> </td> </tr> <tr> <td> <p align="center">BRCA1</p> </td> <td> <p align="center">GADD45</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">Rad51</p> </td> </tr> <tr> <td> <p align="center">MDM2</p> </td> <td> <p align="center">p53, ATM</p> </td> </tr> <tr> <td> <p align="center"> </p> </td> <td> <p align="center">BRCA1</p> </td> </tr> <tr> <td> <p align="center">JUN</p> </td> <td> <p align="center">SAPK1</p> </td> </tr> </tbody></table><div align="center"><table style="WIDTH: 689px; HEIGHT: 43px" cellspacing="1" cellpadding="1" width="689" align="left" summary="" border="1"> <tbody> <tr> <td>RAD50</td> <td>nibrin</td> </tr> <tr> <td> </td> <td>Mre11</td> </tr> </tbody></table></div>
