Eph Kinases and ephrins Support platelet aggregation

From Opengenome.net

http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_ephA4Pathway.gif

   

RAP1B

Integrin-b--Integrin-a--Fibrinogen Complex

RAP1B

EphrinB1-Sfk?-EphA4 Complex

LYN

FYN

LYN

EphA1

LYN

GPCR

L1CAM

Integrin-a

L1CAM

L1CAM

L1CAM

?

FYN

LYN

FYN

EphA4

FYN

ACTIN

FYN

Secretion

ITGB1

Fibrinogen

ITGB1

Integrin-a

EprlA4

FYN

EprlA4

LYN

EprlA4

?

EprlA4

ephrinB1

EPHB1

Sfk?

EPHB1

Epha4

EPHB1

RAP1B