ER-associated degradation(ERAD) Pathway

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cANX

Glc1 Man9

cANX

EDEM

FBX2

SKP1

FBX2

ROC1

VGCGL1

Man9

CUL

SKP1

CUL

ROC1

CUL

E2

CUL

E1

EDEM

Man8

EDEM

CNX

EDEM

Glc1 Man8

MAN2A2

Folded protein

MAN2A2

Man8-7

SKP1A

FBX2

SKP1A

CUL1

UBE2I

CUL1