Ceramide signaling Pathway
From Opengenome.net
http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_ceramidePathway.gif
|
TRAF2 |
TRADD |
|
TRAF2 |
NFkB |
|
TRADD |
TNF R1 |
|
TRADD |
RIP |
|
TRADD |
TRAF2 |
|
TRADD |
FADD |
|
BAX |
BAD |
|
BAX |
Mitochondrial Permeability |
|
BAX |
Ceramide |
|
BAX |
BCL-2 |
|
FADD |
TRADD |
|
FADD |
A-SMase |
|
FADD |
Flice-like protease |
|
BCL2 |
Ceramide |
|
BCL2 |
BAX-BAD Complex |
|
NFkB |
ERK1-ERK2 Complex |
|
NFkB |
Flice-like protease |
|
BAD |
BAX |
|
BAD |
BCL-2 |
|
BAD |
Mitochondrial permeability |
|
|
|
Transcription Factor
-NFkB
