BRCA 1-dependent Ub-ligase activity

From Opengenome.net

http://cgap.nci.nih.gov/BIOCARTA/Pathways/h_bard1Pathway.gif

   

FANCG

FANCF

 

FANCA complex

 

FANCD2

FANCA

FANCC

 

FANCG

FANCE

FANCF

 

FANCC

FANCF

FANCG

 

FANCE

FANCD2

Ub

 

BRCA1-BARD1

FANCC

FANCE

 

FANCA

BRCA1

BARD1

 

Ub

 

FANCD2

BARD1

BRCA1

 

Ub

 

FANCD2